ࡱ> FqNa9OpJFIF``C    $.' ",#(7),01444'9=82<.342C  2!!222222222222222222222222222222222222222222222222229" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (//-tI.."eªrx=I%Im?+t4jP_[bX\ǀpNh {Kn"$$Ns5QEQEVo$:0lw9*[_LӤXKWaVy @hzPh5-f_7v=*QEQEUK-WNK[, _nzg@Q@Q@Q@Q@O N4 H\%QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE࿴Vp9KfFd|흫21ww{x^5ΓA3j(,gCӌz6M.IwA3)| ~ ׼xlu/tC <'NG{/54T\KdAĘ*V<0Ԍy֫x++]6 -#mxsPßG?O.$ 3qY$[x}kڿu=bTM@K?w=[&?ҼPmIJjl8R ( '#9-I|Cw/QZl+*yg8 gk 2| 𭧊-#]ͤ{n'|<r8=q:5z*V[{6`-ʹfv:`w?\|-kl5 Jnm>[Oi _x{[&qqi3'b.m;cPA1^`~zwL=bhur@(j4+׸Xͅ1 |{5et|%+yG?u8q ~q瘁gZLuiTH:[<1򝣨9u=+j3Z]隼Y.m 6uo~}ֶ=.|7N8$t??71i7#PXrwS^zWx;\OĽK[/ ȎZĊ7F9rx$qśx#RińE%i7W7NWk}NsA>5ɒ}HK-ϖpqTWq:)|*ɜzYO2%ٹI2|9$l$"'!shC>qڄ 19&\|}:-$v%m 68뎕~(ZyEvGoW.cq޻QxM4 PE0ON OGqesi0Ӄ ?:Wg^tѼ'_1)gXrQ[h_tG'{8>|o] l/,d3 Q@uͬ$5K>e@pH8#ֻp4*J((upgxl㏲%J&.ܱ~맠((;յ-/BVǕ'q@gr'ićPoeIH8=~>YOxSj6$Ž22c=1[$ǁ]&+< V+~:lG%e]ƀ=[ſ-놴pZ(? sA8O Þ.iCH@2FQp}#W }bv}c[xQFʻ!W r:WkOM?F%%.-mo" {Hگ7P=(5^ơ WY+2GvᘦmA"/i*ƿ{!X̋izRr\һ  n<[ydĺ<7$y[w<}8k; h"ԯofi@!lӸ^/5ӞGf'U$$"z\~4? ^^) y"FiH'>j>2;w}]b>}kIӥ.X2 !%I8F"jx{ş-d%&B[ ʨe>{ XjGo~7eH(s5'?us xw=\wr I6$Sb) +g]|@CAA+X.kZ|IHmԂXN:z N|8;oD2'i^n`lnc'ch|ޛ=;]{"wx kt R4Ē+g=rH-GIӮaHBe*ݹO$P_Wt e'rgp$ȡH27r:OxL^kZ柫&%CE"7 95b¾ Jd~<"Pg<{执h NXմ73Fw1.짼EooK, g"C}yml,>%#8ש|sƑK(g=Aۀ>Z_ urfܒ߃:;nlZ?8*g1Z+gFԩu;J-oܕMT(( ]aR-d7;X) j}yntK tFc,T^/3[W֏cp-nw[@袊(((((((((jzwmc29($ܐ+-~2x:GVo8<2't?nKȕœ98> wP|(ҤpӼHsu~[9|KOX.`p@VR'=Gǥ3*)f`:p+xrK tUWY @tx.kǚjzlXR2QW rZz ~,Qڳ˒1ٞR;pF/ [[L\M(p] rH<ʊfʅW 0)RDwFT_xE| 3܍v-g'kIqLprG%Cvx?ᦃ}m{U_ks< B W%gZK{k42_)B,Q@PZDBT&~jNJ9%7k7`9 %p8W j:G5CSn0 V }s@^Q_3O<9kZ\iRGMw➕izu(l%óL#,H%Nx<$k{"&OF0kݿv1ZOf6>)aMJ fE.]͜G>xjUoncJhQD$@w9cQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@AyekIi{mʹXuO鸶 ]-}O͠]XFtUOFLjei`xZ( x~.#3kiYRIrĞ⳴߅ ҼxvѼ h?aluQ@xK؝49[y*[v?-u4QEQEW+,?go7~.1߭wPEAaɩC,^G%@egҴunxDG~np~ᏽk<D$.N\2sIȭ-s\Zޭ.HD --c91޽s~'[w$7I9m;Iz>x-iujkI.d@A8',srGL{Q8o^jn[6?Y {mO7zēG&GNtPhj493BFA rzC/3x5$]>-/t}2-͗`q.{uدïp icMZYǒ}5@Sᖵ F}S $ pT(3g!j 4ѣ\SX>MC:d<fQxB=S7w2P.sF\>GxXNZ!q" \z5|(^_ ]izO-+Z2(T*{zWwEQEQE@5c@sKHU^|18bW4XN-S z((((((((((s^~\ -%^Tn؜skˡ*TM YJ8드C@!_GekA~i*ma1d.Krs&džiz 5ӑ[وmWV^ rpFE}Ex@icF}ԉ+3"<b= K_յ-2[kHv\9iїRk$5?:޻qȚ\H#,[!1sT'/x[11Ųsqߥz?5>4o5-ݬ5ݢ E g=+cu;㏋u2 ʹ2#|뵺'٨<Mwmi FW u @/MkQ'Wl2$gc  rP:/u x\ޙ-Λ4vVV ˖RppKm#$6[Kt[?eG%/(X'v_a]]7[G&nTFG#}7R;R[|J!zuϽ}EQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE|{\i!jZfo,ʹɌ7܂':d[#wz6{{*w ]3!8 e`l%_ hW2!*̄KGp⯍Z χt18m`sր2!Xu t˅a mgs5^kvw"7+>!h|kŝgn,՞(IHܹ# ``cl~9^?G^WS'[+IQc Z~/ĝ&K X!fC*.6VWZ+vx]8u.p?}kgm#:b/b@7$G &MC9iI+```vUPqAmn,hPKT*˙# Њx[o[8Lbf}2x*ubN]:1[<Ƅ4xO^yOzi7rG:1+cr23` gյCCRYBM]qQҵ]Uѵ4@]7(X˱I'UӟN2jF yPp:QEQEQEQEQEr<;kW1~I#Fdu${W#;_s(((((((((((((((((((((('1$brB5Ѷhd0Ƌp` jc k@5 BcKسry'袊((((((((((((((((((((((((((((((.#G+Lva9#LZJw'iᶳmyk⹬*!cvM[ $ +tFT6 E ]PS]V ڢ5<^+c BH/œq(4Mx1xSS??€#D:tۀ¤ ;B"3|PKEs~")F9da 訬5V yXM\s`~>Mmy$ # L/(Tf6/;MH5t`k;5-8t8ϳ_ dEd`cT9d#>_ i?+(f//_H}ĿY'$Po[IdN7+O?@VS[FKMa>CsN=#a!h\26warF=C_ l.$ LB ӌ~4EsoB!} EEsm/n絗25@59/dje>k/o7@-5/\nKLsg~sxKsggt/h/ +IsketĻp_F\wjJ884Q\^4-50Fe%еK,i?:GgBjx}3-(OЭ~4jk騮lj,>ǶکUFy=0J訮|j$>mEplo :+.u2bak9\xr55-JH]hW9 B$>2NmÌ{jTPT,4{#?*9<{ɏoƢ:璏l?2r؞5(oP&OC[Q#ޚu{]ϿmǨZ: zl_е_=@V1q}Ķ~ЩO?@tV'Bm?ۺ zEbn?)ЩO?@tV/Bm?z Ebm+jҍoP'E}\[O?@4V@okURkйo=@VIÚ[poL[χ ۱mz?ԢWHOs3vS F_-7*oF[EbEEU]@>=O\c`=o\dc` ޚ|]ό" (tW3 _ ^LZQ\@ȿ?IG&п?I@=kH<Zi` S`h4}^^mM2\Y)h W 9sW!, 4rK1#$#`29?|{g((((((((?ttP[o]=s?Tz(((4Rˑv8!KJW 5Ge&Q#1W0v${קiwF4іdKP+r 9u^=|uxVK)R@: ,9I񕧃fuEnETp3qk QGaw2Fmz]'Tws!-ToL|S@D\Οc7Dn䝤ZV3p@ |l)\d` WھxzKԴ3xD!ɁݨҨ? GiȀ 14.F[k#zl3ީxP[ofkmH#cU|((%fXb3ݤ28U%Rq軺z g4MD8 Ir6xP`md }-f.)6%Tzg8x>~JӴbm\47 pq@M^rt {>QsM6Ir/'/,i#ɿ.]giE89hh V^gb;$v1P$$G aG''@Q@Q@Q@Q@Q@Q@^'Zxڵk+7E6SǠ jEPEPEs<|9m[Wӭv@ܐ >ۭxRžZ,'xʜʂ`J8Թ.סHMջўF؏sJ<3\꺅2%^dҖQe#'8;+Ҿ'UԟeΝ˸*;cΝt՛Čs\Ɗ&<^ >TDV۴8*zVN.q},0IZ-KtP@飯~eG{uk&vMF :? o"-k"Āya${PQ^-e/x↕z~;U#dx;^9 ׁ&~ž"ȱB18=^#gMu ;[t(7aSd޿/L]Xd+xR"êTvh9;*+&{irH(j<* [-X/ p~tQEQEQEQEQEQEQEQEQEQEQEQEQEQE淾֥oK{/E J+)!G~cw]kƭg^Ɩs̈'WQ@[|)!|;-)Y *r97n[׎zPEPEPEPEPEPEPEP1s%KM-*Zon}tQEQEQEvnm" Ǝ,O M!#dg ?:0ϜF'nFNN })E$RŧUj El@|= W]YKsR@sز}ӭyI |+iL:=i7~AO( Fhm'WԴ˒fw0e[c~@Sm'kZ+OyVWk"<-Ca{}xjk7Z+B8Tdb4RƟ /!`䁕c2H5Z΍оb[nGs\' ,2M!Lq0[ҭiI:/u ,_b DZ@Bʹ¼ztYwsƟ13Nw% $oU.)%Ə9.׳Q@6Ɩl hzFI!P! $'n`m?X]j>%ѨjV,*/W@T3u`94|C?zƓG鲼Ic&arOQݐ+ּK^..OQe9_1eF~PV p͎r+(δozwZ// qQ4;`7 ]8_p3O/:LV+er+c'e2N+4 Hz MaϕG ~á,2"5j@bG+h ( ( ( ( ( (1ZVM lV??P_QEQEcxRsi$'ʳ&NG`v[;O4yY\NCAG`kZΛ@Ѯo㿟H1{diF##|cc$xFµNBzuN-`XHP2j|9ꍪAij -Qe,wh~\7<}nQ iR& 01"`q{[)~+;oQ³7<R럥l3Mk :[p@ҶI>czZy/ j7r]x{I7v\q<q"zgve)h; >Ͼ#3ߴkIOqo@s:-i6ь$0uWDfTK}F1kt2#@W>iuS\5h{Bwt;~\v%hbLp@ZZaiZTɧivr\5 P34>_T>9GBXфAm rzM^\Ie񭶭vEecDz3nG`+ބljrM'-A3&0O;Jx; <9RO1c1mWs(Lj_Lig}w,:c$xW_ 4KӬt[mRT9&W#ouǷHk?' E SCu ҝXFN8}1>t?쭻Egss@>ay M')o#Eڝp^q:zv2*Y4IU$I9xO@L`@BK\n'G8yg[4]>[s"c?u h/-Ō.q*ݠ,8 }+%5>$v3m+ \{Wמ𦡫V|;HANyeyA==]O Qisiqh|z|[TEێJxJD<=v le5r(}q3lw?|d5d(OKghX~;cr#q8>k>dQ#qo5LV[Ac&2Y7pwg;8<`tz/~n\aGx9 =;M_PN.DA Āzی{b-}\O|d¹(9 `?Ak SQ{r6aoꯩxz[$]ޥsG<94?#LkeMWWtaojfyZ(iǫO'׫´wciP}-0)P} cEi\Y@BrT:F(=p:ydhgEo)P?3{t; e-c ߄DvU-6m‰Ж!S|#Zx37h-&_9lyA5خS\-phfjt~ר>O#V{7ͻ8qUkCGjzX2J띸@ cxZ4 g2;Y'IN1BFKåXr3-oB cОקKAҵZMh&M͹ '^{v|?q#{PMeHE:2#kgHo/>3x a@H]IzWjZsFg­dXTRU:a_Xqw`d1 t(J(((((((((qB9ʟUhK56Wqh[?VP >?3c +xrͭCƨ>?3kc +xvuh=t1 }CjM$ kZx7)7 .@4V/%)4xhLۢό2:LCO !)?ƀ7h!O !)?Ɣx4oI4Ebc13i/ O + {M_K9A;ShfOZ' I O5BkY ;]sN,1'T??%?ƀ4(((((((g}~"xӷ[yC}|\3uڼs<;KLy%*c=s:Huxo'[auVHŬ3ɗ L:gֽʀ ( ( ( ( ( ( (96e?vИuwlZ+^n+(((_čfqxJԥ6\u1z;nRH]_񭾩a$(Yr03\bƖ4qۼ8a8#?q:ƿ j.`RkD.pl?FԼB59Ya%$e&8^@FQX:mo H:̖vIf!,ʼnfdd}3U#V~`VbI wP+O 4C浏͸t1Isg dgfA.( 6sz8p:V/ VRn.c T(K_|3Io[Q t1/ӿQv G'9$q׷;+ƾxb%IVrP+07N1+/mPv $FD>`ӯ쨯4sM_Yǎ,u מO1Z|F_Jw Z]Ə|KvRFUSvAQ +/5n-*Tg)cnOLk;(5O0o[ oU@oP3ր=Bߎ>e7ƚ GpH=5xZo ֯iwfc&{*Q: +ď fu ݨmC ӱ88p_&jzƗmKFLHJaD3(,Nrs@ErW]XXĒK0v!PᒠϡxW'|dfM"1$:t'hԮlԖ{ż% v+`<vTQEQEQEQEQEQEBWExMݠ((6m kW`6ع˱!Uzeטi8mEh { (xfuF D;"={ƣ4,Z/ o$QHRA 0z "w7`X<hN5Cu]ViceiZisdE2k^uo:^6)PC,/QDʩ'8gO i7_e?}J>eӷZhOwciX\]X"F~=?hK,pBM")gw8 $z }սZvS8Y61Kb—hYy4E|bfMCG!%FJJ @,O w4tWxst/˨chpiKȀg#+W-ҵ{1RGe;s~q?tTwח0Eo@LT-aș_nzg tU)52+c&hd4$$sr*{kvJTv(j*ڼ~}myོ~ ?i@mNZYvpI@9ntWh.nO!u;8w HwsrI'Tۇ -%kL*+Jsw[:u8@U,b)WʪۀNOLtElu [ALT{@(w:ij2<ʄQX^7mׅ4 }ONfkCnYU>P:ZhZ=aMlֲ[G;۹Ɉ(r#8:tQUl˻-hay?4#Zgu?^jK\1,NUx%=h(Mi^"'76s :>:AO ]ɧH;K`(76mL B"yQq-QEQEQEQEQEQEQEQEQEQEQEQEx~ߴ|W&"Mm 02AkgxZ𯵝A.H3o$ `gqɯ("mM^񮵣&(7̍$ EQEQEQEQEQEQEQEʴž,$Sjhlę>/S]Ur?WPEPEPEPϿ lg&oo׌ʺejcS*(TP8 @}>Q]d['hу7I;/&snV6 JfO;rq# 𷇭u[:\7Y799<Z6Q˛i l@*F8 ~T_ |`-jg n߆QwIƬt#(6qקѴԧԗMӧ5ȁ|mfH¯򾡪K|-_i6Pڔݍq3 %pdȒ'$p`7z*x+‘,tdYWdl" ~T?GZIY-ݬ" y< (#4Y~Z[Ƃ9ow#'̐ }Hkm. qm ʷ2 ocr;Wɩǩ=_ƞZ]ʩ{eirKv\iy9by=}M|L[YGXo,OE{WI{x±\#–Iv2XC}|-cud4=9mnke rA~%_i WQ.Ph~j+/S2яojB,u M*}u6ImNH穧Z6đjmhۑ.YBP↽?h^| .*)O!Xs)*܎WW9$wqcr$Yr9%~ 𾗩F@ӭ,V0F0c=BEҭ5m2A; ><'|`p74Wl aGg'od%svΦ@q崪eߘ^π%y i\噘.Rˌ1Zxt{Pw,r !OLN C|97Z^in6W IoABҵC¾!UP*f'ss1/o3>ZO"iUI}H=B-;GQnUJ7T3 h߈V׀%I8b?H0> eAtE4KM|;]ԅB;yPpO#^|&C:{ dLr ,Fmk4PYI (?gmL yA4˞=Ǡ:/-t$9$OkPEPEPEPEPEPEPHoaD}w& nPEPEPt{OkI.!:F@Fi? 5IZHZI.rr1Ҁ<-žVW)̱Z@nYb )|O6OmЙ,LT.d;KFV-3N;wr5h|5jڔf9&F7Pw.0IZ}5k A\!H$E1C כD_~x{5w#2{;{tGkk^~qrSuB/|ItfVSͪ(u'5O Ct$k^[m͛/}Pg=:a۬ ݴs$ଡq“x~*oY[̟ܵhlcs/|Ӗ[EmoEH#4\*( |3 +šީ^I>ŦYJX9=ɠ>Ē.XVR9 ;qട:-Cw ru+Wt~>?5ޱ׺]H]c 0V8#?s kxB)X:n?v53\|kZְcɴ!PeRa20~^9^8\Xɥ[h ;)đ› w@9@r0N<9}o/5[i|.mEr듰f :*ΕO./V6I>p%BJ,C=t4/u]_QrY|CjLِwޡ[O'ĺxZE ЊIwʟt;x-u]loa øc'I=Ou?i+Asom!f $Kx/Zƃ~km/iH:{k]Vn@pAQx_Ox؄ۋDAj7R}FK5`zkx_6ҵA 89b`7t$r;xh}븵kigh/Ĝ^'$Uj|M;_k8)_\>0;#ڹrŞ5Y={UդWj0E?-Ԏ btxv]%gy'[ S`.60RxB;EҼa]{d r:`ke.⸞+[ As*-MsM L{kU qD!v$#|]$eE2R=0i= CSyh0Kx%BjɯnhW:j?"UHH>oDEۉtxoI d2܎Hn875ņy]:W֧=hJ!g~U ٨|,:=ΙbtyykF+'qq?_LFc<* >L}Nf>izu:kUv|dp1 |%kx[U^[Zܖ8[y|?<-eX+&Yc9'1GVGgW*d@(Q<9I>XI4O 7/Έ#Gh/SfXO-ZEF;ʀ77 ukmGG35xdH#i=ّ=?+۟ Q`a[۩a 8nHɫ{E7^?J\_2+K#)gp;d@OYxko|ec}~5-/qK{eP@a~kë_xME :,Zl9]mXDXkB @EQEQEQEQEQEQEQT;[˻eQkC2K!#7>՗'€:+ka QkU1(€: +^o):H&@%,74EdCcC,ugWԚb>6z}jo'Y;@4VWA(<:L;?s}=>w Z+#"?'ټGA]+آO i?,ҿ[' z+'!?g4IZhu˶ 06Nr08<8-S#7xVvgXWoyFWO=Ojʣ>n]CX`C]O] 4Fo0stVj}L*訮u?f̏ ciTOx7K&WҠN>i 6?94\.* xZOl*xS|5f?UtTV {a/QGZ? ?(EP#f]"W-3 o>o.G-n?JԢ?/Zm_Я_?@4V/ޡBm?'Bm?mXۺ z]IOX5@qӆBΪ? +%u{j=Lj'.Čt NDKOlb539-MYA?9^ ^j K2B>@TV-ψ^̨D<ofU)~sGEs-HG=4 ^'@Es %\"?W%u4W0?uQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@(.OwnKj `NwcCޱ|SG~Q F$ pW#ў08̮Heubs?k)w2\J2U22p9h3of:- QkqZ+΅ku,Qa!nw\筠(((((((0 sMvub?ۊ(((i^yD >:ɳ=3t4=>}Bko%S$`|QռqKA&6d+aq 2񻞿?ψVImo,mwJ 0SzP18,> i^k9mFn 9љ8ij+m785 >}#-ˑs6 FpT<}ZpqyI$$H둒qҀ==ܗ7Z7=GDd9\2v psÌg 3]MLZ A!Wpr1zU_&>w-D }y4_j2ۙpH|*$ }7Ey̿ikIv>>s@3O |X4KK5[^`,v8G~z'ƍ'ėNN, `V,Tu+7PERQ@ EPEPEPEP?B?k~O2%F` FAk>3x7A%./'xNZ-wg;8@Exoκgu/ x :PU>blFӐAe<5੡ծJ7 x{׶pp\=ş j>,g,=Ͳ|RwmH$~y]>ffL`I\>ր;Z+|ii&? S]$1yNqJ~7U{]x٠1մ3;ʁ>5Z6Ht8tdA5嶡g m2X*s*ū oTچʯU,PZV?G@O:𷋼[|C~26S^B1oϨ"  j0lmn8Qp"eg'hO,??“Od Ś5ۍZimnFnw'о&x?ĺN:H"-.l9NT ?п *shƛwvTKyd B2;㨭h6.ukEe.Ddx п *_ӿ?°|5G^,M"o2\RљUFK&FN>8ⷼEZkFFT,z=9G4/ G#O"m4+OjSW7"}nH2?uǧ5v^ZsdY#l# Ҁ);OT ?2s"mH"UF?*L9Zã=k75^^)ԭ<-s HT HgˑPy")t:gh:𿈯$uKvO)_k1^IPpY\7h:aLG:Ž G׬-tۈc{|ɿxCWUy irZxK2U)Asn />S[cOV]#$, Ϊddmbpkdt\Jǔc`CGoJoxa[úI?R4)n_:K+sO/ { YCq5gs32rr9𝏌ŵ\5.!`Zu&1 u׊V6WW>?Oj7J9|nA$_MxJm1Qj7#NW<+M !0WڽŠ8^W*kȬufر^@\ϭ}!Eya D"ndƐvfc~s j,n߱f4PxWU>vw\i[hZ0g>}T+&G+z(E"k2fFPfF2C˚FE,ѼB/I!T5BNx|oH~+Yh>Ѵ?I$ ,9B. ;9,IۀbB׾(|Kӭco:bge\xkP8Hހ>t;Ÿ u/ jzUV$ *~S3`x?|_q1O`%Y\݂G$}PQ *#N4K^3t t%P[j ޹''ׅSxɽT|BG9#~>XƯ7!WPHaOK.p̯}03O%|He5_x'v4V`>c$,1q^讥]C)ȦQş.4Ly'lxP2Bc7"'5RJCN6LPEPEPEPEPE׿oaD}w& nPEPEP9I׉?q|ev/閑嬺̻I{L(9'5C(e*x 1~Rl?ôc쇄~''̖^yI˺wPGx?kxR=ðh:lq(|#<ˇػlr+ xC"y'D'أ ' }rh7nbpڐ=G,t xz+{x% (Tm8'0Bt-0fHĂJ | qV-#M`X5M>m+*<<Ej[msxe8*䃍ĩU\cGi3O H\Ϧ%ظx#2sr{}KyZiwRZ< >^tnu K#[8r>@*]z~cssy;=՟¼i"Gq^o:@+DZ@C,^Zqzz ׷jZiNt{3#AGVvO fޗ8x6#C[ 9Ӵ}/GILlVV"@>h5}ږ5߇亙#{w$ 5oFk1~j"M2ǽxtO\5 T}.E3Z<k {xm-㷶8`BGjQG8zVX(7޽7jmg[ bi XfF#~h:Fx=2Ys#+D7Z> ]'Oq@0ն{&$lH#R2:rl>(Z=ٸG#X!.pe 7> ?V` 6r_ SZJ&DR\A'98 c9xvϦ]_EԭY Јe0<5B2GxNN]3O!Y$1)w|!r{}|5n=$ǩ 2zZMhMٝ(.i,s䓞xmƕxM 7hȐH41/.޽{bN|Wu h,:w{;n$:; nG(PJr:OӢzVc(FnUT.Sd 1=2˯ xouRxEv;&  kТtk[vJ 㚾uxl.5OokHr9uZ_ -,C-ݛtt\Ftvvzu/Ko41IYaSF^Fӥh=#%ƔG"J\|鍬T6Fn'?8}=氊,ϹڧوR𷃢`խ-|@D!K29y`WAԬ)RREKc1\_ <@['s Gx J_UfF|\3밻4 ~ўҴ- Әp(EDvWMoO/,i ]Dx9( }EIum֞"ߪEC?bmے;Q@Q@Q@OR:۩7 e]= s~x}/猞1mDE!]|϶ SihѢ ѿ/a)4A^ShFDƟ)4E@TVY&'[G?Ɠ}g4%Ʃ“IY6 ʹpJI GWEd Q$ЗkZp' 6A7?&?9\@V`&zkZq]'Ӈ4SX5լ!?ƥTh;W31X̧y@2?:EPEPEPEPEPEPEPEPEPEPIA ( (((((J(L@ sڔQE4QAag3(&(Q@%-%QEQEQEQEQEQEQE0khM58%ܪy9>=j}ĺ?dѯc09!R~Кi21gsÌu^x:^+'Xgp~h袊(((((((?P% =(((gyuٸgn1AN D2 NՍ־$q&Q}XP$7WSє?m\,9M7M·IwCUKBX$ ?N ᯋp]])gklm$] yJU>96ך姃6Sfkl)12FpHr t-KZP5;E/ H#ǂpxQ\,hզn2](mTV8Rkk=b0Asa#}r((*|Cd.6:;"MDmW #;OzjJm Ě 2"~Rxs@Eyׇ,C^i}%Z͖Evpc/^=V=FNҵ&dJcP\GJIc]grcpLɐNٮODդцiqKr7^[jwSҴٖ+B` rO*x- VcDg;:jy(r-H:[_кx595XU qWWg^o7y1,Nzys%ИeH0T9'4# *@ۜq8};㆓qZ.Z^-U8r sWo>7x3OK9Z&Oqyai t U49].n\ULC }g` d O  Z4PiG?“ wVA ~iV1ȶRdE 8 [ Gqº܉I|Z@];S(sC6Ef裦8h:8XwO (4Kt Crt}MS'|#1[ĖH–$>PNO¯mM;4CT"G]+ʏp UH}xF΂Ė4OsiR1LH¹k/173d՟fܸwːqp1hXjWEΩ/fSQ rh>Bzvۈ2c?!𧇌b3fNU5xSA{-v|1.XNzRxMf 4E-q !p14g/Nd o!LT 'Vee[y>`+=zVz>ccCG5Umy$z xc3S)? _U ]e?+Laf\)]p=Ox_ų\Cjs- %CBdz#=EMG\ҿ?“o з"r_ kj#c\Enr@ksĿ/[;[CRGh%y*o f. ?Oo з"V/ xytAw[yyox>3+(f?9)۱Ǿﻎ??\ҿ?”x'çtnOş|7n |Pw)w#88 X4I>y4'"?BT=A0gOiS)^>|iN/hwbKď1# ꢸˏ\gZMԴX#)%QH6D9@-;*h<;Z>i?\W|N{k[?zHK"S,O(s;m><ţjגŝ!#=hF>~T#O*W챀xb;>odo.i>̨A o-4"-WRmౘ 26nx56#N.$psvږw$FF9W8V*sƾrvnvqy~m׈#bou S?w0s\ c0=֫oeq+n)c&D)::0*yW|\4,t#Z(bC!S۸vW?rC4_U/z~iZ*y8HCm :V|YxN.uJ+880,όgj,q3@rW?rFtψI-5*"@X[F_һKEtXtPdC,sIVg 5]޶.-x$I#`m5]:ia;r B4?j4BP~ [|OSGXK"DQzgK?dBT 9}3^сqGݽTxWL|SiwQnS,; :t'i'е隽]ypx<#)[qt].&܂On=sjm|/}<ZxLiˊ8QێȮs9;K{VVm6Mۇ 1Hh>J;u+IJӤ7&vkP \EofG]!fbpO񷅴-o٩xP۹ڭȗ U8{}>ry 5=k{$K8cy;v0x8x)1f[T^$ry_F񞙯h&Dž5-[Ve4ki)PL GR7޼WYIWC4X?WU"46oyd?69?t`g$uڵǏ#eHr@ILsCuz&a+Mw<3v/', =} URZZm|,O Xh"Ι (e8#%37`WK.Vr\y*#K=Ŏq̑4"XCC`a#%Xez_ߍHnztVRD[@l>~@$(_H< xWS0JkBv; 1㑜Z|L5M2\*VHH݌aI1_N^4vȊf>u-̰x~u ɄCV:s񁚋^?Ι&?e%c紅ɻn8'ڽZV槤Fl/e3z݌=2:Vw<%%aI:_O3 Mۤg8u@>xEԴPQܼ® mC[NZmT*e $Vj`n@c 2aDiװ*(UP:0)h~;+t@~# ~5w^<Ү Z2O:mIߖWdaѮU2`$ܼdP^(ӧҾ,|2Ӯv~NF䙔"\~:wʄc R8pUk臲/D10]TJ@8uKX=6 y?|w^'𷎼Gܶ>a~i#r(9Dѱ0}=M[Z.Y+goUv Q@c<sB>1X cMN${@\15|.GYn-7) ǙH;}2=+cmjުS8˪(f@(( nHL #N?Ӭm7͒<ۓ8 ؞@Q@Q@,m3š'VBKX I76 |IoM7rҢ0c10@Vgsw!w 9I'PI$QO$:÷aI 7a.2Oa8'~"|9]S0jH y`ے:c Cú6.{K P6m@ta&JG/Du i/G 6aJ4؋h-جiO)E,|\̌۸M  P oW%`Gm$X8Tdtρ~kC6۾}!,Ozq@=+χbIB"sgrO99l%ԵZv+x!!h`:Qip= tx< Yf!W'2]I8tVӶ IBm19P1`-o2;t3M_iɽ736g=@>+j.ⵙEgG\@d?\W>5erc}G>$MJIY2Kd4m{U>񶃩ii-p"N?ç⵵#1;_]f"[WL'WUp9NnkFMBöR\'#8fI+sZ:DŽ ~Tҭ-0FWhaq v_u|aO&jm$ޛ;΋7S9Ȭ^|3x^wi!_&}|8m4 4z6mfe1/x5~x3~l;3Ƕ1@+zJM -=Km: y絳AVGa~ WSC]jNmJ(ܛXpI?,.5fӡ}Mc1 ;*F3`ӽ|ϧ wTOU@(gm[夊6/BF cȵ>ux7oo%<= v'& K{X$Q P)eiZL&op(5|1,%ʕ;nQsEh f(>}ۮ{׻ZUçiog|.IcܓY$o]1lw~N|ɜg  BLӢ𘲆MG.>2cQ5|7M7mI׌l{dO\P=+ׄ?oۂ#; S'9}jڝ׷:r%'$Xϵ|iS[xov3xY㴌B[scsw^4^ Լ+m:^yn&25C 6H, ֿ:645̩s1Hy"-F~s괏~ҼC=+,v݃h?(\@ >w>" ֱZj(O\yVZ'N" ~tP.J'om]cA^{>rOBrZi2ebS͓ }(u+)Dz*٫%Ke9:qv̽r8:":n0  !='>}Z8tȷ"UdLX0'3dυ5l4&chSe*Iր7.;P|7319]>#Y$FB ʻ~b1D+u߆M;wgy\ngmѐX ӂ{8h?m>Fdek) 4wfIT '?1ڀ<#?} ;[,#U)4bB8- ?,[XVBO6p8]*8\eȔ۷g37<;ptFID!{Ir[U鎔Mqx$)Z[ܝHӐF=k]K$4_ʅe98!QǷx]u%jC)N2A8 M7𮕠h`MKg 1@G@numU\G#*t9'+vXY]'0 jſ4[_ 7+osa;$Z&wHJ,ǽ=I@QEb ( ( ( *֐,X\^lhՀesPΠO>[o=@4V95ZKmi[o=@4VO[Gw||S62FH[4謙u4-Py"l^/+ka/iyOEaKq D֋ir3*z)~ 4\& @ཿƓ?^@%Ϗa뿍Q R\_Fu2>,&wc&9aڄ~Ebt-2GJn_鰒$MEqe|Yڢ_Z\{w@nP%li۟7@V&G˟7I  Q\?1!˟7@V~OomL8ouunQTbU[a X^ҥHc;pA@E?-K 0~rxv꫆}o@եlR7Ҿ>wAwkg'h.u(f\nIXdg}b>6 4=+ȶin/v{ _O7m(V?Z@Q@Q@Q@Q@Q@Q@Q@v?ۋWˇA6Kcgf:i#\G@Q@Q@Q@O/na5l Z|QwjY*qt##g';Z̳[֑JuUnt7 ]x`XO?.CaAnam _L TGf,M$lirUn0OJninu}Rc GXP0<Ri:ZjLmueFy#'OsC.Ee7MT ?G4OJ(0xsCNNGM"۲h@BM*ۺ/&@/O%ͮ\I7m~}ַ&@/OKxKX:ۧT:G]{RԴ6ϻ%|.2ʷL }Nr  ݍNENIҢGaƃbKjhIImȡO _C5@7S)_>˾MsV`xƞZ.}~I7ۻ)^ ,۪!OO_i_[P oJD ? W'VG\ҿ?— н"n@?xW+)xkgV*/"^Ed/CF). gɥ_ hr ²2*0\!NT鑁Ƶh 3 W߽Ae9G=}M:A+{ .( _D􏳘|}=37F?}+9[P< `܏Qꚏ]->mV38`1HAqWj?5?XgV&#?Їj4㔣 C?r*( D`- o@?hݾ 0]k]]X=V&7K3U<HB/h$0l2ǀh!m-S`7wnԮ1_H<1n'INN.'\w[tP do7H5{AUPKkȗ|*xr#`D" C'? JA$#Q@!q_3zOB3zʓFMwLGBU_ħ?"?]MO[0]ۥŴ 0eaGpxB!1/No]CEsAsAgcZ  (Ckeg~q*AL,+!6Vb1vQ8(./{|CZEnGJv?" ү}C~kQ@2c_ͪ߻_3[P?5 ڷ4ط3CF~'&CN~?mQ@ؚ :غ Ecc_ͪ߻_3K}C.~k@2jҍ"O3c ֵ}fGyj_o'=L>]Aj(32jCv[zq86Wv>Wi(U h/|Y|"m5[2>Ffi>ҹ Qm-@8no 4Yxm4PXo'k195۷Ÿ\x/Ķچ 5BCgz(5 VGlw_΀9Q(<9A{s؇+ 9@l5׵{K'u 4{]=Cg I'M|?Z>hGI*?#9l [wxU5=2X|퐘8ET@Rq y%xxXcoi1II*N|3I_Ou NRאT<x'gzw2h\Z]D\ե g8L+-OYL2;]eM8cDu_4d|guis}F vvR:W+/ei\IghЖIs ̨KcA ^?^xbHΝ\wë $c9\nX|3irMGqUwmnp錚|S3Q FN;ۛ{eb(e;q xO>xږ/w)u8 &:ź׎n<3{޴3%xϛ&·|'|3Kԣԯ4?.o'm ң<]C^"2D?:}X,@![8#s\Wΐ&[𵵬s3$nvХ~^ qu?zo<7 blo)#QWa9gM}!Goe+[KyJ9s@(GȂ=bm$Haf\rgzDŽCc,^'u"h#HQ\p:OxB].2J|Vc d1:(((((((o_V>:۬/cOVQnEPEPIn>:;On~Ku}0YVHc$ 1mF{q@|Zo5:ō7R;! 3bd'{ ~2Уfuxj/2ݟ5FGr7oKiۼУ eq|VC;7v$s4ki |/װ\I5&H3xۑ۞3@T/QOէHa7쥏˹6 v'ּ]wxð^=nflBpdx`coˤivZɂ"?P98q-e7v׬&2C-6![d@:5ƏWUͼzvJL쐷^Hx$sSß|oMV1^h74qe%@9]̻6Pe/7DnaNɎLH<=q\ϧx?*|C$ʯ-b\JJq;[@YWʞU׏|J|ks[%Ԧ;9J Q åqKna|XxAEjz.lY- S~U9s@oY潤#q#( 2TI'_uOVz~o02;s? 45iyhѬaq0Gm_-،pzg/1-Sѽյ6Q®G#, ~l4 ƛ;\޾iy>IF*T  =qIxO _eW[6o8^Ukcu:/jz {n3.~LeYS9r0⵭r g@ąx>0 VVZ5=$_1y]ďq 4E5"e-as}o'vv+C^g%R%;yywxc=x2д.a|;&1~Yぉo1y^x}C mjd,w[J΁S$ῊRj^+߈4 t .QFIrˢKc.lZ]];beuo$\>5y$uA;=6Px Ⱦ2:ڄM6׺[,\mMud >'xƧQ9aq*qAtO}ɾhڇuꍩKxZ?,l2ʆ=Zt}Z{ۻn aE\sC42K*"8pvsҲ2 BPOLHg;ºi^5]yw}d grI>iww:ljur9US?eA ۰ 62;CG_ͤ|\5a5߉6'vnA@}Mii[Y[I 8ѕ wk:ß?]y7 Q+\? /H dךm0^kWWj:Ιh$IeTd 瑐3վ.iZOwkypH;7v(G|7úUncv$>0r2T3ɮsZM.kI/=٥R%hP0@==;Xg]υu{7TdK;+/!Jķ6xquX8F۴w9zQEQEQEQEQEQEQEU=CTGm䗟}qxnz}n7(C$u ?OKm +'[qG.(nKU ?ڢ? ţ]Iuª]x-: 2{آYUEd}Sƭi gd?/4_ + wNo&Co =Bgw/ N>0wOu?h_ +!|U.]N '_y*Y'kQYha)4F'V@4Vo$: Ɵ)4cRiYh_ӿ)?ƗM Zw':&K9]Ϗh_Roes+~чRhocq|)0PE 0?aqڈ^4qʕfc|nQ@xJ}W؜P?_Ν7aRkQ)艨ɁZޢ9D޽B/k1z訠o;='!{?2zh[xa' $"/|II+9Bg%8x6 ==tP9|_bk1z訠xxN0s$~HIXK#YG<kvo +Hnka ^8F0G]$n(7ƺ}xe|1`GcWȮg1WE@0XUѯڰGkkb?hէ?iէ(QXVb=GcZۢ1?i)5ui+jſVvfMSע2obݷʼRvj( j?SMVz2A"({Ӟ!!U'R,zÃN |zxM؜*HtmldI{w*Y*ƣ n$:Nv( 94 u!1&<6|371ZVϝ7Gh?)5Wm掕6C?'5YMEsCJoex/(k+ſ4ӆs{3p] 3Ė/Sls;Oߢ0WN2c 68?`.9cNWݢ9p5ж)?.@(9_Jk@T>P@q@Ź:ϗ ~oLַ 3}#h6>qZT{W?m@пo9Gпo9]y^1 fy^2f@>ךM)<tE>i7xǽhx.ךk7b]_r( /_?z+0<އ|+4dد@ 2}>EaĞ*n4fMU9pH89(M>s4Rnx-nER2yЏ{tySEQEQEQEQEQEQEQEyz|d[] ! 20ArT֯yα$nn}1YZ5rJc2Ƒ ӅuL{6RqiVk U o ,A qjږci4ctԞy#noh_5]'QmPy\ʱ "[Z x>.=JKKVkroa?͍%q@~1Im4wwK}vbp 'W/_^5$z\}u_@t?Z"jQ$SF5hېp=~2tM*wvE)#ZK0im'V/"EǮb")pCI_`ׯh~''#[;/qYt h,|/\z?l*\v \(]sN{{ڭ-8(ԵFhU,ZLW)lu3~uǍ%s7aP:m<>>K"pM1I"9`k|efG d6Y_sVѭ I¶AҮ$s"bN0Y#qZWNC$ʯ&N''+n]? iMxzNFݡ'-=;Wx/@#xNxm?Qvv1wQZP\nUNI u"]cyC)XfPI==m/ORW]$ r$2(mm)p$+2#^]oIPM>mN;)l$`35!Zw-n]Abo:ұ>x'Þ,o~!%̂MJiێN2I''xR|1ZAhڬ*1uE_pOPk2$H!I󿎧E> /f;' $ (á<֕p_֚GͻkC(UH F-ԃwn۞qkCyWv־L W i4<c[92X8q[&.]Sº WmQ>“lsҀ>GI:2NAU Fmi-ljXO'(((((2$r #Z÷Gqy&i"Pʬ[q\qǥvĿC'zaoJ Mc, _G>I>%o7CE   N3W:yƚֻ]zoLE؅*A6yuE;+8(988hw\7\jڬ +}d񹂎yaFi$ѭm*s=.BO ž$?i|OQi*JyvW9'{=_Yw2M/Cxw Iy?+9 1}EE|kƕuUaWT*I  ZZN/|];m⛋ Y4*ezS?B4W6/=)oumKt-HVV!(n8 xg:Y}kO!aZ[=pU@SPE'#'i𯗮I]rxڤY7ءp0ݗ(:kƌp 'WΓ|IN':Y.d#ϒq@{x|!6{2o\_hز d˜7΃w}G:}۬4vۯ͕P@ls=~|9iXG#Ŗ(Oix|gk*Ioscz 6 3mtsx_AoXi\3$i(UT^3 Ey Wxi&%+0pqӄSĞMQ}{.>{-i#@sʂH8.;ڀ=b^|HxR:j跺x#EPr 2nbķ. >R ߵI*Fs䁀@}mXO}{0 Tuτ\ڜ.y%H;@/" t=>x~!^h9!*Ԧ[{峒 UCqA24+O-˼s2IYAf9: ]^ [_](8&oE.{iJwxt\IcktWLZK{;H(I4#Kh̭6 L.H$=c@^ZŤs1^0ǿ5 ?:W58EQ0'<~S(>h <3 )J*A<ړUWjs7qe{cp#U7g{`WsErQP7zi]F~\ sgr,}P-mnl'b:$ֽF~oxZdNx`6pIiTȃRTXA[uո"6p:u=| "Jg~ܑyںB_> YJ!"eQJ$+ ( ( ( ( ( (9ȴiAX2qJ#(('4wFIm6Q029+⸭kM ]W1z(Egxl1cPXl'<漧JC:_i~Y$R3UO'};߂ZZCM*H T9]7TA -q :WQ@;^%4hOijvFQ!]H '8&|]'Ò*$[ݢ|<#}h"eCOZ]i63ֱ7XN:_LJ~&k*mJ)Ԓ`$I99 iTPhu6gDU#kX$ kRc-0`;9 cm 1dk3\[$lcI8c6m'Ğ$ӧm$&%N͕봰'&\.l 2,ǖlSҽ` 0)h̴o2i$X[kE7` z \K|?jj-Ⱥ&V,r9*cN}B'/EKmTi"=zrN2|MsCx&geYˎ6 J?pjx٢$_iUwʌ`3p aX6 ` ]hyichQ-7Z(|Cw~y&t{I.aNl)65_kڶ-֙qi",m$ fNq;WQ@/^ΙOk4޽µ(R%NrwTQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@VƺbHai8̡MqPI>ǹEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP\o҈zjL:ͤv4qqF 9QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEZ~(o$t?3_O7^Ey Wgfυ?zm`˷zgfDž?zm_`ͷzwWf6XaAssrGPc`_ ,AHw(9=x9g=}zWmm_׬Q@OG=}z |lxW珗cmn_׬Q@QV#x'L1ި >spIߓҽ:ya)Ôk|:kFX 0s |@<ƭ^Ey'?XON> 054Pq6k^Ey&?c/ ch>8D_GפQ@[7o4? ޥG # .~"ݦ_P[^ opHN<((IJ|+<>\ ECmkL|OW@Y k]c"[Z;tPxu&^&w+Ԩ.37G-w(˿lkLMTsbԬey;xI*df*09kh%ѨЉ~xNʛX>wףH" 8.qD??QC<Ey//^_?//נ(GOP9_^> /^C<y$Ey/^_//Kנy$ED??@} %h 5>D??A 1 $8ɴ Y?<$ gr u]UXJG !Xn.q<)OGflRڗ2a7[n1P2>3ܘ?go綧/ԟMk t? 4?EW-m~h?-kW_Щ/&A|!B?-imK_*h._Ы/&2mxk|?K g1֧ WC|_MxGm4|Gm~i|Csoh*/ ol|'(8yڙ {_1~kc_Ы/&A|!B/R47Yx2'=_A|!B?  h8?(wȥZmzp GTI$Ѳ6Q01#|1D iNz wբ/*N|#CNWo_[ǿƀ49 :' "?40U~n?U?{hGӢ/*N|#CVWo_[ǿƀ4: Z "5h0U^n?Ux ?N<$?i?aI ׄ?jaYg=4U>jՇƞ!4 31=4N|#CVUoUo N|#CV_M$T%&@'B,zU^n?Ux?{hUghYпr;_+4iX_+vR”{BN??a?ƸR_ˏ9G)_/JmV?mWk+•}BN\?c?ƸR_ˏ9G)_/JmV?mWk++iX_Jmq~пrR_ۏ9@z_ZI˺f 8vR8#Pia?ƧDJ*aGQW O ;q)πAЛ9\U]KGQN|9/iUBiubLKrTcqh_S#ug [_zϞ1Og __z^1Og _[yA1+?|-AL_ng _[yA1+?|-AL_ng _]((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((٠F3 ˃:qL킷JFIF``C    $.' ",#(7),01444'9=82<.342C  2!!22222222222222222222222222222222222222222222222222)" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?( ( ( ( ( ( ( ( ( ( (ko HY摸TP:x ZG /P+o,Rf-hIe J-cí'k5HHpI?4Q\O%Wß /}_|7vWO[HsUmL[ʜdWo篆U.<@M?@Mm?@Uo篆UuTW)gPWEr{~!_ ߻*篆?@e=|1~?6AwUuW'zcTQ\߈?oqPYEr{~ _ ߻*篆?@e' l{ gPD#m8fkOҊ( w[W|cQEs^9񝟁]A%yD0 Oa<@-k b:!C)1KV<P zf/CAj2M黂BAEGѻB%U`LmoCgXx@n˧km{| I Z)7 #>n###4Ro\gph-?^l6q;;"8ٷrz{_/PxPoۦ#+.pӧ~Efxw[u\yWQv7F\!hM4VI<$QFG`rI'^qqaXjRnF}3FF3ZZ) 2?JZ( Ѓ5h='1K}a}ݣ{eE!e?ZZ(((+< }?nOϷ:`8:{=| 1S .2878?}UEPEPEPEPEPEPJ:RQEQEQEQEQE6((((((((((;yZ߅niy!q9e=+k/|Q˥yp+G񾳭xtjƞa{o4f ͇-uEyW=nğ|;\[>B9F'^N%)!QկeNf*S5{@%kLDVPs''oOzP|VxIm55[$g{Eb7p7v uǠ5_s_4kAI,5n3eKy G8 ^/)Ѧҵkq58h۳)?+^{+-[6s>I# 8O\ o?i[{ifG c,l.E9f}}fi2w)8m[/薚NK[T؁I$I$ /scyj$a Ou/xwTŪj~$K%E`pOr W|;>+PP&m @県՟xM5|nd$,p0@3@'/G>xw>1C>l0Sڡu)fdyٷ?M|XŖ\Aur'hLF3@c$fx:_cj @H䉶n8Б=hž)7AE3ϲC)9QAa^ K@< m2م'qТ!2[KY*B\P (|?t_+FGkqt衴崄a"TEY;-oS}f.*F 9~µmxzM.6̷y08 #}&ЍՎ#;\:0p`߲է>&|K- 2s]]oV@F89 1]5}1FXW_7x`wn88q@i߉w/co,A'K=89g5l~[O$ŊQ˻juDm-. Npxr:v:tZ>cBYnʊr((RR?yM}[_(UM}]EPEPEPEPEPEPJ:RQEQEQEQEQE6((((((((((+>>u>ygnd'{y<Pc omgMD "Rİyes^/AtN!'fRjv\+y9 گ~*H;X OkKrBX\|{cڮq=f ybUlF;\ZO:fXk*UDr˹?+G1,%te$;#º=Q%՛rHcih2=]r$$:n0==xGtK N(Xgy]Osk~%`rpT~ؠ¹O@d9<ݯ!y176Ԓ,!ŵ$ (PK2:g5 wƤ|EF 8w_Zu+lHHz!jx%ͭ2AyѮ|AwI9sӯtMFԓou OaU05>!ozG/d64h呉>v N1Nq3N{$}RbcW4iG-(/sxo b7Cpm<08?}xxv><֯f7[(#S"l м%nt wW] GɵI=D cUҬ$LW!*eMoWZ^2KHa]4*9TH*埇W'q/t^ѵ80@71*;9{u(5~\z\1$H+e ZA.i:⻍bVCr6nYw"((+(/s_V?zF\}_EPEPEPEPEPEPJ:RQEQEQEQEQE6((((((((((޸޼gch`Cx7ʏ3s.Wi lvqdzU[6Ta,Vީqȡ'8MYn5M7LpFHg I@'\g w b-L~dOA]P ]ows<3F|Ҫ|׵ ZxvƁ6 +x~Ӭa #tUI0>xPo x^۬SYj<# `m]? kVZW 셈.G]3Tt :.m%ϗ*tl~no-!R\DH*Ot ºv?{pK, @GavW$WGvp$!r-9?iQ@I?0(,mcu10'j!Kt5.i=/Q]xDpd6gr\`O#zZgzL>_XhekmiDXm;Ac̾:A*qpz>=&=nmf+ uM]c.?Epi}[|g[:l֒}HX 9®>QwcC:eҼc ^n~wQA^z:АZaIvg8qʯxԖ|>Ki[Kb<< _|C O?S[IVxE0dwRP##ҪAodDk4jXOFݸ {n"v owyxM*kH|;$~j̮@R !R95w~5$W6с*9o1,Fьc9#vwz}wP[[GM D\ r@][Gsk((((((i)GZZ( ( ( ( (EPEPEPEPEPEPEPEPEPf(#/|;+o뷮''|?+o+oqhɣIMxp0xsxJ_0LGڜm(e,Fu/G:xOJkg0} sޗ7ycI4崒O)ޡ"W]"5i_-m)ij\(?i Q:Ux7X>.Yԓ#cj O+\!uѳ"ȫ;P1ۜ`w_ɦ^*]JKUH6 t>O%]xºTzcujqq7B00hx,NakiE"ƪ %^ 8]+ 'ᄰ[NVH E ;b$ԻWOO>/M.XeHBH-GPzz?¿^|1ͲŭS5k{,y3+/u')m"%[R{~6!+~53@/+-+H46_e޾rS dc)jZ+$;.3$Fr9o ;CKs+g|ĝTjO? M>m>KMN-E.!D&ҹ'pOqU>)X.:5a0uF-p0Æ$<3o_I^_6S$6 ݹtfOS4k}hf*z$F0:dњx@]iv*Qf$?fk2h>KM 720j2Fx7W@> ~/^sI>|HV9YfmC+n7 Iwizl֗9Q3"G^p 9B'⸎m仐툤e $3qM|\:6u hgf57.'<<|#"Q$l/$u1s~tό"{ ?N/""; 19]enm`i'H67Gc;`=wlo񿊗Zk3v"tO(I;>]f>_U^Uy d dg8< $Cuw^#OxCNvn؋v2:ɜ \9:|CuCB.E[ۘ B $s^-IOs\ZĤ)+X] r?+|I{uSmaP1"?x GO[+^8=CiN=}<Ɍ$ O>'-X.CaD6N9'p`QПEc"p&U v_j: Y U*),AGc埜z3x{^; V)u":1NH<8wuw_uC7\53@nFqɨ%׈CxgRlu:Gб&I 埗 98<=MjᾓJx, %E&#'@8ZxS[YŧjAAo0ƣz֭iSĒA_h0K2b|GOٮx]xZox]dn݌mmHvvg02I"]þ1_ O[y\\E?}𯖪:͸q(O|[sBtKGN^i'``X1=3Ek'\wk>i!fgP&mnpgFnύ@K j|H<.% aC> `=qֻ/ _X6SZ92E*QA<{wQOV58$?5h:( ( ( ( ( ( Q֒u(((((QEQEQEQEQEQEQEQEQEQEDmv|E8wV oX%>;b9Dʫ#&3}r>~)M_Jc/n;M1^}|J>׼5.}q 7k0n s:zgk?L=žm^24plou=}q44W1)V7F,11逬 =ϗ|QM7@nt+di%v}20Cd•`Up0x`r84Sd!sE, {/ڎh lnE']VI8ր=jje mnc1ʙ# Qyz[-'L3>>ʓƨq! AshAr$k;<]%ITG>p*ax'B:$3!J8^o|Yf׆ꏶi' #'zc5/]>λsg\N"U*@8N@'r8=>0]KV.tɒ9#3m$ ۇ 8d+m]3FPw󐫌0#;Cb=j/|T4=^I5 ȄogdtW-j}N;2k*A`î4]ᦡWVF]BuI Fv!qcZ6&m/u :5䊖$BˀT}9+;_84MOPâ vrWpsZsi:|8@ 3wQEQE'F}G_-?piajԔQEQEQEQEQEQE%(@ EPEPEPEPEPh(($śՠBnxT vR2s^=IG܏"2Zԡ*Yl81pEPEPEPEPEPEPEP\?cmwFwv q^=ksZ.4IK}cRG9<O\q4P:k]Cѵ}1#_&e} E2Nt.csj‰d\#PʺމjFz[ra*r2A?|qMo|EBgڌkH!_,>oNx9(HBTѸ}4|=o v6,Hܑ21P:΃55vCL yu[|bu[.I֡ͥi?){6/O~m:M?m~ւ)$ A=><`ДP̷^?|wk>{;]N7)Ь: gJu:O٦+5:gzga>{.o< xUҮaILI'aF`XuA@|M7:Xj&q57sȮtgL`T =>WTVܲ#+" jS$=ҝ;V&܋$P;/*(ʬ>+x&KL~¹q*^x.i-qwVwh'>Ə_j/$KXsB%*ON=S~Uy/)EbpW sTP[_Jqӕ fgCxrIϵs075P]xKQVscwV<}VWӭŽH('@Q@|'ѫ_RW6_dG:rH碨I?h((((()GZJQր(((((EQEO4|OnLzN=~9tiu+%b%Jo(h((((4+u R\y.I2ívSQӬm>{ tvIC+|M|-qq騾[[[8*Ɇe9۴sǝt?U}/Azw*9J+ӿT^0诙{xw*9+__1nj9+__1nj9+__1nj9+__1nj9+__1?|bT ~/z׌9}xo*>d__1|xo*mhM}nt2HA?1f,@}Eyg:x{Y[IT9A<8<ϩ QEQEΫ"C͕#Mz&gcJ$$$Q: ,ԓ_sK7H:n[I($9g=(j( ( ( ( ( ( Q֒u(((((QEQEF<7tҘf 7 ǿCϡ> |GxXnfWe,;¼mUvW>Oi^4u3, [aU8=jW:^hЇQ-Zݓ< RWal.{I^ 㿽[((((()i)h(_o~*ɤ?/Qe>v¬@&tS6g!PBN885'}ߥ h _o~)Kӌ!2(*\qt8PC2k+b%O.ln6vjEd xqCiEL<ɒ q {y΀dCIԬH cGVooziv ͪJ//4,سXK$O?X/& xzK8B2Y!6S!quEb\ı 5%~8ާB|'BƋ5E`?_GW_[P!_E_B|'B5Ea?4_ б_Mn@m ; hrIOB)BƋ5Ep_"#%ΥIJjÿC )t}R)&LHi"899> )E2.G l}(((4뫤xkERm#my\6=k> hcUӢk͍:nqީ|Xr}ج=;rz/<64NU"Ua!^oZZZ_5-[pH7;GҀ=ފuY_Y]]2D)Q1W(()E\RJ\R@ KKC@ E4u%Q@QEQEQE%Z(((((+y7>^vˉ 91,QI攞:#t(?>0_ x>di#ԵZ 7>szN,v48Գ&Cno260ٍ@I[yC? KY鈿 %l# 0mpAE j#E `@j>>k_eeda@|},}7^@Q@Q@Q@Q@Q@Q@(IJ:EQEQEQEQE( ( ( (35#ھjrbx9^沴O5M:EPK$!~=7K-_-St=A#f'ޕGK7MpO =W#O_Ig Ci!]wGp>xz8=:+>!>nc *4g@ד^ xW¶Z_.cfn]y< t\oĈ6Wм4q*q5#<,`>zQX0et u;Vami1ƒ89㓧XsvY#2?G{ax xVVI(++ d'¹c/Ե9@g|]*+H`9CN=EPEPEPEPEPEPEPJ:RQEQEQEQEQE6(((((P⨮t /[Sт6 dW:qkuw6$H7$r}iArT9&=QM( ^i[9rsJS^Dϛ@KʐuEKW?Z~hE*~_񮯮ܴm9<ι!2hkZ> ">H<-Taxk))ZеG4gNĖUՑ]6m;0SX~"妔~2Mzq@F=iy^*$K<9 '~,55g\7Mԋ aSj)E)@ IKI@ KERf((%QEh*ZkSZiM(;xzGqq 7PBI$sE$q>_wvE-f 8qh;iExt,rO$v("EI#*"pI'g<6Bey~Ԟd#dUFy`3,?o X2#Ӝ> x 'NS }tZ ]؃ж8_UTEDP-QEQEQEQEQEQEQE%(@ EPEPEPEPEPh((o.లQm,2I\vGGͧk.c/mv[(p'g#EQEQEVvxEҵ1qJ08`ysK36+Maq[0LR1MzMWP[ȲA4k$nFAu5?jjw7 8ӯn9o)6tWM_RXH-ͥ3Ñ+ z(a:5iK7h<_>7ՙcj-PU H![7pZg+y-%T)$n2`;+Ο#t}vxz^4IX s;PYu/hw4ŋ1AIMa/ş Rn䶹AP2 0J3@9JӠ4=6>E) yHP;\/( :XA397AStKki"*hGr9QFxR!Rhd]C/#$t=kZ_MjzaD'\dpBEu>,MoG"n9YS(OElEq4qPJ jR1Ҁ^Nh@4J(-(Nd/$pGS@|G  hw81sQGrOV{$x_'nBO[5OD޵5DF>a*l@qԒIٞgOPU]GQ4 [t/$G'IT70Yus*C(^IU@$bcg4kW>^Iys獮o<6Ų#__Mǩ?AWu'ηSULE" 0~|0K>jC8qXF+ި(((((((((i)GZZ( ( ( ( (KEJZ( +Y@̍HKEr5a ھP߰799ޫC&uebDdN@7 IݞR a׵{2tY|Hb4_-a]dS>+/DW̫,N2FAˍx>/ŭ*`h.{d9HQqnS7<椦| ębqiL7)W&o_ƃ$D1I>|E!9Ҁ;? FkĚxk'89T> UG@G\m|WI;l|uw4bvCT>Ap~bAxܗh<AhB)guLDᶜ3zq˼(MNxH&Um%֡k}9(:`cugso6H=9chXڀ'rC|JG(qULC{Ծcy{Gshl&>Մ=zTIb7J/́@$p~*甯z6wiR-pk"d y|mp+sD&Da`?w`U;TP\}嫙 8w 9naKYyGSbɟŚ L$Lo%L8>fIgQ6wp_Aym 5'Xd&9KׅFd+䁶Je8ԌONOS.>jzx>Q+xyպ kuZZAHB@ƉkjtQ$ o$pJ ;YnneH #*$Jŗ@}Cia"YH*8'dJgſ7< "ݿx]8qׯ\KMvXSDXt8< 皩\&=kZѣl0P. 獯LWl =ͦ<y+c0B6ԃ(#ojhaA_ ^k2$Ҙ4%[%ԜrO&xjyg r0'piFQ4GW@ٴ#vMI#jw zve+4rFw 1MnPCǐ[?h&<9;ŊIRB(  I09maȠD5ź|rWccp$V<>t{8BC: g t<7tՒ2Eu7d?_zWy 䊰)ɷ)X9|RhcR[iG>\#ޛ>ya4GjQ䜏=lTadVh͏$1iFcޤiPorsN{)UvTj1 v(I^z#!O+GLbI!/@O.wYK SS4"q=FNGCu("##r>aoy]?PhnOFӞvZmXhʞM B@XRMpmεj~mf{ST7Eof:'Q<^OqN@mAQK;wbry,I$RԬ:}B--м?E̟@9'\w-xkˆ ԯ6.{q|qO\ sYX''''N(Br?MhyH=y$mrEt=;/-Q52Y,ir/=:sC) 1qFQ@UQ"cU@UU uPEQEQEQEQEQEQEQEQEQE%(@ EPEPEPEPEPhrDpB¼~8c̙Ě#fP2^Ǽ^/R{6$״餖Bit_,G=OuE֝-zXƃuݜYK `䌎vkcq,I r__RSU zzU6:EEE=aeQG#?,?<7sIuzV)DxeW$@ހ:Z|YXL3 Yz`zⶅ%%:puRיϋ6n2=@m.m=aV5M\?1B@I󵧃޵v577:qw1@a=NL. =+7+gޓ Ph-c[ q.ӭ3KHRD@iBÎP5<',~*mƙX񖴺@O%n?V=3x/?5ˋ+v-֓ú.R猞=9,*fdܧ# 2_馼#Q 3\ s k -kO4 I#gd`Y giWK Ф&8{V`2L}0~#{ dujxz%Hɧ ,ąOqE ?5.2)33Aj6L1sƋOOSӚP$˸BHb87zW2mWwWqڬ6 1ŴHsLP^[jV3]IJ\Fte#Ww7)qi!|^Yo4Ť-דdy5|4SiծztSBegv{Gpx-xNQU~T6Q5~/xc]HMZDR,~\W9B QKJ(((((((((()GZJQր(((((EU{+M:mm`I"(#p8j_ a dPOy{u;ƾuoZvJ1g%\Q@&iuؼo\ݼ}\5*dp0;'Fk⵷ޕ" wfsא{WiVMrK+`0XxH[SO06r5p3JpP=qj}MCL{Uڳ2"@YN9|u~+7VְN+eXNT5ݨi#to|ڞ WHn0ÁR3jm+FĘ1΀=^a +SЊl|l<ƢY;Gzb844j$s C&/CBG_FhV0_=ioԭy>rqF4XE !sj7dJ!X 20H+_p@nV`{DŽBo-;qh 6;7hNr^-t .?L S>\,*/Q@jEldYZ~H漍`$V91N- r t4Mqv~լxeKy@̪3ӀqqvAv=>8b8>!%[F, / 8"p}h`ԁrhARH8 q,$°#4uRIhKk 2wg \qAW*^ ;R#1 Dgi aaJ͆@-.~'ZZہ?5$,=qǹҧLMRkҿL=0zqsqc+EܽJ"Em v&j/b`g"3^Os>N<'隥ĩ`s#נ~MlZ }}Ow(8e ">HFYʹ0IU$umXg@[z~<\օ=8Kc#@Q?̎RjS9Xs~=fM$ =-M&y$Y8zX(I. 7P7|E>`ƾFZR]m#x=Wϟ<4tf=nn8q@Iz'֕ger>lQ e@g5%*\G{ΉAiq@ğƾv}7fomTRž!ċ@ҥj+KfYm2FӋPU?~>0hڄ#̩!H@ iۛp1q?Z=c_Ir?4rHZy}w$i7aD8Mu4=e_v Xy IF8W?֜І*=Fe4;Ә|ʤӊuDl7C֜% )|"Nvy?*e3g i4i1@8ds~9#A;7/s]JG^(&H%R$lv=+>'6yt⸈$W^[qKxZ(!2eG^Ma^\׶R/Kբ-kY.`>Vp|w#|Fm r)<)k#[bҥ@hjmbz/ָ_60XHw+4oku,4](\IK' J2{&g 1 4!J7?Z}!@uNzUuw:Jb݅Vܸo%@59!jQ &M Qwc*ҥ)s=:^= 5/~G"6l @ -0q+.i7<[Wѹ3slASV9ALek;uH?17[[B.v)XP|=9FR v)@@x 9޵.G")~{ ʜP Qݷ)\֣F;~j'L`Cs_-F7 ei|/j+^l?.<:TycL}*w#~YePq@z<#6~t ߐzFU ͇PNsǏ|=2]_yZ)F?uB/BIg޳^"Ӭ3gqbS1 4?!s qZ:3C% FLe^m3ӭ eդ(ԥY4>QքI~# Uwˎ[MS$)@(BɺOMWB_%q_"FF}ag?^c?>xZ()5&)h#ǡ M^Z1b;7\wMkn^!/@4:b gPS8JG[/z> x/ѭ'$_5Wd ȦSsY׍}ny ihlR9I?u8gC7}r0Ȏ%]˻I|"tW\"Io% e9cۥzWT0F5<Zn1FhԴN@ EPM:ln`98u]J:KKW(VD9#>,:汧VnOce[hzyHg&*'Ǧ2uEWӬ`[ U+om''j *%.h4Q@Q@Q@(IJ:EQEQEQEQE( ( ( ( ( 1KE%k}/Zv?xMPkk1o,yÂ/kgYqsy$XVt&[iC=j$Sđ6QAL -Iڟ+!A # i&pi"!8t~U}A5 zW[%; hTb4iJi(&M4^=ОDSA ׂh{N:_u;TL?ݬ('^LK?hVHՉ2c& vdMxepyڀłE42ɕG TKE ʎD #5Hd6zm/VV\3R?sX2/+޺X8 \ׂ-uq)1ΟkmR4Thڨ0PC|U.VAϕn2n~/sԊΖEX6n8>Z_rMHo^{JRT8=2;I}!'}k4&U-xD"p884D o~6ެ D*)k@$j}\^(׷[ʳ[r 9l(߽I94>Z(i( ( ( ( ( ( ( ( Q֒u(((((QEU]CQҬPU啶`'5MͿx{V8d9 R%`bUpH8}h.kάo𮵡+ۘc{Y!"zuw_ u}8ZK8绲Lwe!}QT4}b^Ҡ9W8%O  Gj@R Z(4PhX>9o?㳏= GO*c 8J.$!$ƀ=}QL:(()h( ZJ(h(()GZJQր(((((KI@Z[_kyoż{)+ +@Ӭ|/Wh! zWQ@+qi>t^j1In%̹̻XЁ lh.|E;Ɩw'PdI i7]{i*TY_@h}1Clp@+z^_x+[LC5֟uo[(y8!x^jX'kwq 8*QsҬk^/Ӵ cGSU hVN0s[#G9/B>!xy,cXcXO1^xl_Fk`X&uNvrHꑠ,@I)_5|Q :^dCНh'3: +{;d kh QL.$M<wR6 5qJ22P}Ww;H{7F֢A!r2HFgU\\Pfa-R1 j gؒN~0 4\7lc܏ZR@~tZLz=sJEX1Q@21/SI l$7ޫ0z+wþuQXI~8Q׸|<4ƒt(򎆙iSk:"98tAv奇t#  ?A@*URAR<;RQ@Q@ n1RSZpW-,4eVQ5>GxGM?faJ~<۽rss)YIgs'@(+XDmHYp?=@iQ\ۆܞA=xNda.(H\ #VL g{mG ;s@5[ǥ6Ȑ#8< sNU*٦ǧq%rzUiBJIс>Jү$XW#5&Ei8W9hWmx6yK&MU{[-x4n21V9S94:isIրK@ EJZC@ ޖ 3IE-R-Q@Q@Q@Q@Q@ (((J\FhTfi67r=@=dy,.>^cP<7T~6ϖ9K-+'^%M-n)f61OX{0Zc8yұ|wQqxV]=VFPnb VB)n7Y01:զiXCK?q6 𯈣f[ ~ЖҰHzd):xgZt/X-~ᮤs?Oۘ9(s#{t ?K1 cg̒5ZKX[ 2p\%elt#5lT{PƂȚ5=X [Nq\ ڼJ]O_H;)1<8*/s4 CQ&vT@d078(u#[]w-ߛƯj-!q#>QbAeΡ'V:e&CuNT-;sUٴMnFۛ;C<6v ,{Myׅ|5`6΁y3|R(ܦлd1ϣp=~;Ěo9ōR,Zk9Q"\k'>d(V 8=28#)=j<1~hr ҽ`=׈*&Ojo:440v4H m CMWe@{5[j0Ob$Sb>o [p>28 @(O4&|lEb=9՗pvB=M$r,fxuw~΍4Vyш_uj`Ym93`CZ:-Ys~T֌*f {lfWKjҦڷ6rv\PgP¹Ko NϣִܴkhS֔7@(=i7@!nfE4ъ((RRZ( ( ( ( (EPEPEPF(Z((( ))h~qc2o^$4:(,ԓ^Q6;~vgL`lBǶZ,~="s ~˜b9I$dt`CЂ:}yWѠSֹmiWLT t+/> eU˻m60@utw#+U9=]_?rW9k?.dˤϭݧ.C;(sn%t?h;#TxW*AAqk7:Iu%Քue:\B0@~Kk-cKkh [ϴmQ]Ypyqyq>=%^^ڶd՘q+'$eA;}'M8`$+O$+ĒW)Ws[Be=@xK78G] 3햩^g/no&Wۜ8&x;]0o!q޾d/kr̦9u"$$ ψ `ɩiel6ju⦺Үx%  V  +)msrj#ݞ(TַuY=f @ CmqCjb=ZOMJՏqsk$1#ZW/싷݇qRxH:f%k1$:PljHdP4Ȩ\NG-Ar3oҳ!y9rv 9 E8?wH@?-:W`=:Y7 6 nô>x ȫ;PB6\NUEgb*G/' Pݟ5 76?Z~/Ye]4]Nha["`+NAך n[5:œPՖ^6u>ϨF[p\p05EW,0.HjsGOnly84g-\QKJ\QKE4Ҏ@(((((QEQEQEQEQK@ E-QE%->G_J[{g WT bjzj|/mjb޺@F189(Kլ{]rTrd;:o>Ar2kj|-8 ', b+3cLs%Bc,; Q5t _ z*kA=mk/ Aeyo׶7SJJĈ6A,Ă::xKl:߃5kM5vbD|#{uoF>!CVEk4i->{qnaM@Q B6v#Xg5$?sӥMŧx*EiA03q/>[~>%$_QE.ijJ'b u')vsIڐf15 ^ mRP~ʚ}! +[H2<:hҴWl"_]ОkK;KWPc?Êoyvkh^s@.yeE2bv5횟cHDz@j_S` L@ nRHC#o xO}Wn\לj4O(yB'oa"Y9.9_ lm]n> ZX*Ignh)sM]S^jFa2("v_Jfu); Pp]&&p(. XyM۸xUPhKI@ ))h3Fi(QK@ IZC@ii)hJ)M%QE%(@ EPEPEPEPEPh((((()E%-QEQEQEQE)(((((ARQ@ 3II@ 'ӗ;RQҀHh(RIKI@ J))ERJ(((uhh((((٠FqyT%X{YxYpJmJFIF``C    $.' ",#(7),01444'9=82<.342C  2!!22222222222222222222222222222222222222222222222222" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (9iyCȼm[PwU=:y6#ö H)X330 <⼗Nj[teXb`vl%͌6׺UO5KO8-Ğx$=7iҏ_~:o?vnc^U?ۼoݷ>j JZ(((Z(1E-Q@ Hii(((((GZZA֖ ( ( ( ( (EPEPEPEPEPEPERPQERQ@ EPEPEPEPEPEPEPEPEPE6o{_`ěVG)K?hi$g޳? |WkU$b!әeB꽰?[(((((((Q@Q@Q@Q@Q@Q@ :QEQEQEQEQE( ( ( ( ( (4QEQE-Q@RQKE%QEQEQE(׼ExcO[b ?HPOc@Lḽ#c89V+9W^}#^?m'FIξJSIp,y$S&/t>+y" H4U@D&Q^i.-\vМ ֆ~=- LQ$Y ` ydc8׏A/ kcĺo=lp@r[8IRĉ]^,|j>!U4v$N샜dc|3Vuk_ IO3e֦EBwHG=ꏊu?iLw2;XLUufr S펢?;Q_:w6Md g(Ϝ@-I9#+_߆s[[[KiXd&VF 'nC^,'xVbkejLF#{|zԫXoA2C%)c0x3Jp ag)4xJk+Cxr;䓀9_V:u{mi?5c8<ٮc:njKt -,7!O̤Aρ!5SRk>qۯ'mil9d=(.( ( ZJ(hEQEQEQE-?k;x^=3N9&&ኮЬ;" ɨ!R,Dv$rrxC\VǏ<3m}YI/6abj႐2xEcxG5'۫]fsbN6OoqG? k76VB-cPArrC'x@Ey_<%-X1tnb0.I$ݍ9`q|`V:Ti'YLS}`# v#\ji1\ZVakZsk*C#6##u 㙤Xg#z@~ ԺtSʊb\ bdڈgV'm>n_qe=+{hCœTHiaqŬ9c9 ?nf ( (uih(((((QERQ@ E m-@_|aӸԑą\Wgl-uiQD.#`޽r3_[մ}:4wZ.%{"T>{nqN{U׷%펂Iխ=/m|,H P|Y6{Z<2jY2LLKdJHpE4hf3@ ZJZJ( ( ( ( ( ZJZ)( њZLP\d5 &T1Oٱ@SCpz?!  9w`! I>W[+oDE 2s5 2:X.$.lX!Q9HZ~{I"$#p?vH$#A|O1 E]kV+n`#iʠHvMFK {^uyN)sizZ;ʫ~ʱ G|gG/5kOcwi9IJ1E%w!'Q@ TuASM`k c%vx늽A~jҼK_=w,yL$,b4C9Ս[?u2Lyr.n gNzxRKۯiF\u$'ڏ4]^ CK&"c;qZ旯~ҞJ,$Iamɿ˸l229Pk7oN&KZɨ^M%[H esIAbfumM ;V~1¥X ¾4-u-n"'ь 6wZA;A ,an:2~=KV1$s 3r{W7mg M5uimUԬ 9n5&RBnZ.s{-emHXzW}s|6%ZE 3& pi1D*QEQE(KH:EPEPEPEPEPh())h4QE-@)n(&|ySH82} $X_oVJ-Iq7x ? ë"?΀;PiGJiNMkÞױKqC+ pAD'CK1XEU׌jK2iy.[p!P 讌Xdr E?&]!eT'G=db{ᾲ4 ĺ// oƺVq=Mzd>0ѧDžU1#Fj8`p;IxZ5=&;F{dgXhpH#w4VYq[u{I~,݋N͘C" :p( ׼%hzo<5]AlҦn%1! I<=-<57YMkC>j0y\w?( sg_!sc9]([|jmrhI- ;bqu° 8bY}U-յ yde[(arGPi ogq$^ g#BѲDn ''i^% &q-G*܎`1-sA⺔*|ђ``PE-RPEPEP-QEQEQEQEQE6(((PJ)(QM.h4FPN#/Ýh?1Y'Vk9dw]cEafM^ 5] UOqF9 #WC~ \RQ3@>(nu _i6g%F0saALӵK,Y3x۰8=IڒPB~tkڴZ ҵrIK5ԯݠ4Z)(4Rw@ \g< /E Pb-^s1A;͓݇o#vFhݔ,[}@[68BU $ `tu_ xn/z]Ù$,umz/Ӽ7uuT\5+YѰ6w>𝆈"ګ/fn8[}Cf 3M&Z( ( (uih(((((QEQEQI@ii(E%N@ s3m4yp8ɮpr;|2~$9#%oF2. Lp @x_QrO"1b?SǞMF., >8kKoY Ҁ=%ĪR5^6B}o(;j)g W4;! +N=~D53?,K rI 2#0s9Mo xnJ+#1+?<{|0Gִȴ]HJ.C)mG9 Sľ'oiWN-} *p k+<9V2Eg%>E'xF9s/_ >^4F yF.33Is#Opw,4Ozo ?jT2s9Cx;jc; e%]w|Z[+;&U2V&@Nw|T~i>ۦYx?.ﮖ'%/wB)`Ce9{Z?)Q.LшpCHliZL.= [Foxƍ}Ϸb. #6HL[CO>/->x/LҒg[{LҰZV`@y!Wg kwM{]1Wq7y%CnQ@EP\]+'n֚Tn6*ۆTϡNxOkV-Ŵ$8 vgpӴ,m^Y0]ŽXuk m"<,ztgC!w 2sѿ9mAADwkde6 @6Bz=uKi<]om4%Z~l]W!n>>pY_6 u>UP>ΟgoiCt?J\5.G;wO8 @`k+CV-dx@s}(/ [j~Z9eu ((4Ph2:P$fMA!@ \QE%QEiiZZ(((((mQ@QJ(1KKHh (;p .y AȪڍe%̞\Qk5o!׵ ,|/` phHqGDW;i"q9 ּ|O֣i/5m0L?ʭ:k[]?qKMn!>QϮM}۽C:m"XCHPkOh!u"2OʻXj(U)Zv77vŕb[k)c$q t"AtuwBI'&VuI>4?.4h6si3,*ڠcpr28d%O$It%mYX͆h YM}Ex}Ox>l|lܲq|)U}{>esdSl^(Pjv:?/k@~?ԇ:v;96?ݠ?ɘnVTWSF:Uˏ ?jd\?Ҁ:6Wa|{UGݫ5>?ҰB'#4vUFЅ_> ? g}: c;ǐ>5/MՍ\aM_D6 T1 N3N+?j^&bVcP) U1'V"cɯ<=^w~'h. naKV#2;} ^gտ`,˒eAfNG?NI]Akf0ۼ4ピ 6m׊oa}Z-MbuSb+4QA4sGZpӘqFqQ}6>S@QĶ.o0嶲8]4af뵕sx.{{w/IRay{j4*H@?u`ej24ۀ+z^; Z(4ZZJ)((VMZuQEQEQEQEQE6(J- Z) -!Lq7^yF "P l^1Ҽwt_@>n,C^~f +?} =8+Zi9@׏7/iTL3 s1yf|L|3i3WS?rImۈ=HyȢ<+'?mykph\|H9iT񗈼[jm> SF8`UE*/B:^EyOTچuiq53QLHPck4SFs%Xvd+oϻf>X״M6y5(<hi m$ 0c<80P|?/pڧ1b` O9Ty5@-PJi(5#eMhhȊYEUQIS(:nX^9' V>B`nnFOAcf@8eݵsި|JTY@17_v渽hgUh8 ?0+^.rv.:soƀ5^X;}zWzT3 0O**c?C_'}P~u#C,Rh߿} -:--!.)(%{? YK8nfG#.A 0'z֭x"Naހ=LD$'W2EQEj k^\!PգYӕеvqFwh^ID*SY2'O1D, X>?.yӚ@nHo  *͉pj!"&d<`׾(J6O*c?3Wr"}'&H*r빺>#LW9dž4ޟ>9wCY;*|5|ϧivO[>Zg~E>Gm^3ӢE8ÓԆ]79k\|sXHǨ%V|#LZ)cHMNu7'3m}kl5A8ۡHomC~=8| #tyaԢFӠ_J]+Yסcgp ogck_ |9Fm9E8POej,SjE|" gim鹵.݋;WLĮuy Ii\Phb((GZZAK@Q@Q@Q@Q@Q@ ^;:?դ;]HW5܃q\{5h:W4-X pFG*pO#oNu N@. J"ՏLJ;s2.Hf~ [ҽJA-: )mRF̰ 㞄;bK =Fp]@Ho.xîGCyMiZ$eͤ8l>VS`m!8xFմLn=FBj)8F}מ?ZN⹿xM.w43N UEf TN^0:JCQEwk dFTJ( 5+ -u~{nߺA^wFC#OW)zf7e]CIh0OzP ^Aua 23QEs>ޗRO)4DS}UwXep#=qںl׈| 4;W>Wߓg+@ ֪j*ٗ~XD-'NsU$1i#2Ӫ@x^\oˌUW`I"z1<=^wx~ݱR*x*&_v;g2BN_\w@;L` 6bPA5wb'?1X?m{~4}·!I;¯wi{OP7.Wzg:U`sO*F< kmofLo,35Njχ?ܬMgPhzҊN@iE#P=iz .H k˼in=.go EztoM:=\+R񶁦!i| C^?!x/$nLN]JOAÑFA4$\?kl1^1:\8'^kGkăTPxwV~-2΄:Cs^Fu>sN44hh(Q@ )i-QEQEQEQEQE6fQ@dj$s˘M[xu?k@_c"uW_=9jj0$?ōbr .?J~9V!U*rFM{9fKkGn(?up$َ V#>qT^LnS\g±@ yڝw-Hwՠn"A'03Ƽ>ؓUff(%O'SGu- mсqI|wqoi0 -wZ,k=`}ZkQw +5"ÌN@~ugD(N̓uML͚;Zf+}UR;"%3du_Jx'N^+/nB`>5?n]D\p0y'qj_ _H(Zq\&mbjt;@^)1\LONo0![2?/돱D-w)+l +w㞫A /<^=WoKHZU[,4?"5n/@IU$x TΟʀ5ſ⛛}T\ ^#AaGoz.3CaxNfN 8lb=F1@}NHm7> _KJmfvK`InJ?zXMgpJWxW u n:^ŎHE 0;S׍h_lamZImrH@P~zw;=ZgoFPBM0M"Ivr:P(Px0ZBi3N4E74SLs@ )i:R(E- K@Q@Q@Q@Q@Q@ IE(c^%GxUg5n쏹@Rь{T[PY=wSh(X H<66R_$v/CR0"7_S@@$Ê%m`.)e#)5 -NRw!@cyu%318RHD;`bi2ʜ B:4;I=k.6L~m5vGR'8T`(E@C15-R2T[ʭЊ5Nuh|@ o׊]xƫ#8D~U6: {Ϧr=}Hʖ<Ҳh(k~wqhZv2FHR$1<\GK_gYi6xğ2_u;v]ΰ#ome b N6ʎxRh6wKr?ZWg|Nz\hFEX#V(wr8*k]ۇh>Z$jmF uf ̍4m#N! =[+-ۮMa ʮaW#㧥vz߉m+ZL,-!p2O8#ʴg&@~yhR6H 1$[Wփ&LIshȭ|S%#5(2Ha[>?_W m$:j621󬸧ѵ/ce%J&K0ٸ~|Z}fr=M:Hn"( ddxMӥ;& iF6r;rSɶ4u$$8Xxrp3^G!g|1O M3c!W3iIL|Ĝxq@fY.;dQU:nAi\ٮM'<>hM.d=hq$8v<_H'}ts^wgLW|~* r]Δeu[2)jOV7%H N:j I !eRs@fь%f8EƦ_Vc;nJ$ہҚ 裟ʀ;4!2~뺏\y8󟙱S[!`T5{).K:"aL񎨗>grB:Ŭ>iB9+\/5 0o^ӣa@/J$l g/v7#X:d2#aInB4Úx~3(ʯ<6{l4,G}W+4*ڪ޻Z,Ohٚ#}z^QO"?>: 违=nmۤ}WI42ds5]Uϛ'qoE[fCe? I/8@=7I *vɻ/}(ug_ShmCW  ϣh} *"ILijLn,K'[z[R»!OS3qz̓_z-/bY&=A![s/7}mFWǗ;t@>c@z/^Nm0WI&]D+n>N1ӾqC~ Dɷ;CSԮ SETD! (B\ht6}>KCf1q>@wh詨_fbۚ6```ק^k4O3|M4eL>Y#=TIkoZqFherAc# :t}Åo+w,F䟯 N4-"7#>B}jgfeս\ڼÇ@=1=3qTzͫiwΛqy0 <6N{pw`3@5VA+Q(=J|kE!J嵺rN p''+!.0md|h''4_ݥg%F|ۘA18r#q kVskwt$LBOb8 uxeQ2'y\*Kcx?5{{oxl9CФ$m8QiVeݗx[+iUS ` `r:֟ M+LcGˆqbӸ9rQIwo95L:\ia)śe;Zޟsc ;;|ʰRAArSM܏0HC^PNpGlzqV<G|ffFqFGp'%y?2/x"pPchdվ,JEK $dtP$EܲQ)-O#?4(FNOALא52JM2@ ;`P`? yӤsБZ !cY:L}+ր+MWX/uNMMAXr7[3@$id:s&GJE8jyUbgG Zy~*'PB NռO ȢJ#<b|(RhZUbN9jܷCZ m$dhp}xxOm$R3 ,=knIR(~SOLEUel#W! (jUCV#?j$w/VGUmבH~aH>Ubՠ #eޙ= }%f+2:cgwǃl鶀:@9b\QAii֝@Q@Q@Q@Q@Q@ QE3;X׍c޳Y(Kce'57ă>)+c R@r}j3!$ mg[@o*pϔ fER>`P9{S1:ÌhU?/Y0%ӡ{PNجe\b&m99Y$3\"EEKian gh= Y+sB/QֽW~@(w?#wiWAФ𞴚͜r>;bdS_NU;yr( q`O`O$M1ݐd~ R<]"[PG##jtkhGy/:g6<sߟJl."Ya=QANKN Cϼy홌 P6rw;y#t@% Irb ,r#cӜ_׺#%21>`Ϭsz`k)HKd|c3j 4_OrZ 6$D7 L4>;f{ăxPg v9&X4: @+ ,SrG\|:&-|0I{1RHvZ OytqH0OX:[̰]]] (8=8<-~" A*cLr;sW54w0gf) BrO#xE~$6KNmvvܐG#`s]_=:EH綽̲+`d}ÐqhbX6 |:quj&oc,fFi汍q1TϋҬthZ^[ o?Ӑ8^-wP{ܪ`ApGN筿nc9dc,H灞pZ6Jqˌ㨭K}uf.WӲ;@5coKnk(ү PlbrH=_Jǻ$> [$BFJJ{hu~h>H55yf aU^{dn?55t]vXK@\\.rQ Ԋc V-b؀IbĜX䓓ԷAcRI'sPȦP:@_ _>ϊd\H#<Ưx>gL9v1˴o^hq2TIQT>!#ۚr?"RBDH|+-W?au6ku #VW #<{PtҮÊm*"/~*ֽ$k]=-*! yaB++=7 ӸkNlw/ozb, Xb݋ kzPg5:IZShYpOadɹwtRoji0.Z5r`?*X+ޟ*3s|ܫv(ټIr11"1!?J} +~ JV]sjO<=Օ05i0)A^3ޯhQ U+_[8SZX--Wdk6D.b35,V<tڋ]$SƺT8-Y6GٜNZ ` t4  9 Z4rI$,Sm]"݀1HUh'~<d ͫ3ھlKciހ JZJ:u(((((h TXrʽWf_t ˥P :KқC9 FVr x\,j~T=Ku T)#ҬWsjc XhՂ@ ojҖc8fsH# .ZRXvHqi3>xfYWO+W%5UZdGm|XдiҴDX@0O=YھoisF$GR9jiv b_|V֗I^ݴRdY߆u|?|ۑXiWuHCwcҏhk#[o'?) rEsZVaYz!UP9^83V٠ 6偩Ȩ֦P+WwV־]Z-IUCԃ I<{>aRg QYaN]8'-\UޑcMg̎HR__YiZh2@4f# {g'$_|5/[utݫ'iV_pܥq$iVh 6<܍'88m_7W7#4eix.$Lnq8Ex~-HdJ g[ JWJSvӂE.)ix dU9qUs RHdU^*[8O@ܾ"nKxGC֟ v𙳄+pÖ Fx#K}1wfH3ܘIk.^]vѢH| gs n];jw55ׅ{ ;On\;lpH'<1du62M(; Jv.Xc5iZ\y<B"BNއi4 lSk@4\Ξēz$)Ƒgi>xX`x5-z[ 6 F W<7͊n~*o{v^ ujFơ[%.9.w9^£0ր"rv{Tm͒1ռAսO ɮk }q, nb2.{c_xKM !  dm | m|e4˃=Bő6犏F0FjGV Ӛ1y@47Srs׊hxU^ƀaL |3o5*Iu }kdžf;o4wu4w( ( ( ( ( (Nk~4iʽ5?B1*ETcҘ t,h_Vd(=ZnV#ހ'6{,*GSzU!v=dor=(H2 j{{RnEB3hvh8<3@WKܽ4jx;toϪHU qkzTYXc/b=8ˌ*ǕMPnENѻ *"=@Yk:}9wy+t}2='L4 ?5 l~k=y5ZB173 雷ߴxW/;+ opM{L{o-k )=j43zWm Qh݀z /O!cOy(u^r:qޖ #QRoozK DӢ%ՙb!wc+Ӓp\nznz2Q,iBV:{hM:?2} !4ĤQǹ8zhq:^Y%B<W4אiE4@JQKH:EPEPEPEPEPh.) )?%H鹳W)j@ǜ(hTSG3Oˠ߽0d1bNj-d@@CT8lTeB%@fԱTGd 䓁QD7f=A=Pиyc۞]73x"%Y+oq]GáƷjyj?:o¾f}OlWot1lx6S$-H ?]D8_3E+@%ˑ@Ѐ}VcFzi"z htj]E]Ԫ*1R-NT0sQ-N QQJ: EWC58<0++[2G;nIt*@#=(o=|W!UV|=p}OZojSKx5R ';i]#Hڢ% 9N֥T"CA>ڵ-d/^EWn#?&iuYp 7~)12>J&Өi1D,Džp3s_iKAE,2Ts݆J$IGqjm>5szeK.*mt]MDViE#] sZ:.tR4GUqp8ⱞ{ƾrbG3ĉt~k>+y.nRlDsc vnt#`F0N{zԗeŢJ?̮00F8{AgskGlsol|X1⶯,V\oI9<6.uef>_SW_AlgPYdnåEqc(U{,T d[WaaIhBM0Hfp~^jz<>{( ?Y8*p( 6GJi9Y e 3Lbbc9Fnnp==:W8RTWs2ބzw`G44@Ygp\櫖 56{L\I("=2'+5P/~&kMp>TPQ@xn;[yЈ^HՎ vjՖe%+Nɮ%>RǸ0vb7ۆp7u .,`F0>O3XY,|ȩ|'O4_{4VO ,(# _ky\\ cʽIR5 &9ўhiJZu K@Q@Q@Q@Q@Q@ Hh4yĨ̴. 5]ʾ-_ItP6p:q@yG{UKyB ɢ_]HfevP@=0 ^M2y]fy|.s&v:uU sߥyyBdKMfP0(U \Z>d*c(6b2vcɠ gjUo xN從#q@ #*Aڬ ox&9K5yaUzx܀_HhRe(Æu#XǰV_hZ=O#2nqtEck!d{ n${zw lK kDv¨b}\$|2" y55]b^Csjel7|v pqk[M:4H\|Gpnq@V˄ysF{֔ISƱ֗|.vI jH>4X+`1 8i7EdS@+PvH\*UXzX"]R{{T ؇;x5[]Dʱ3z<|I#C)dd/{G4|9h?(r3@|a BuÑ+쫋P8#iX/Rq|CKj-<(gb ;f+$c<_?*+Q$K"+ɩl4]>A{OVm@y#+@ a@ ZF$6r8]?GhL6@v;1^XtӼ`3mڠh]χBn8 >cKKM@ EP)i-QEQEQEQEQE63INך|N~p*83mqs Pu_ s[H}{m7v[[a^nP!?Ҷ>^[sz/oV/ ށ̘#s[q_'rq94CH?`EO2A+[@['gQnC.'?Eȗ>cph¸p55U_]EB03Ǧ\U$;OxpJ)xlR {UQa~jI8 fxS]/Zao!"A1G\{VCi8hW^!Кt՘8`9Ǿ?*~Y6}#\L sTWשڬ6mc(@0E+8 sO FGJv#K{.p}FG'8eƋ=ߊobӤI!QpH 1>uQ;;G/-1ʹQpH==Fw`&g50Z݅0#;y=zks;6J{"!n~N0yVz5%[<.Ti¾ Nw`3 V:ƛ}}*Um\*]c\>|\Zyw7ؑl`YlN:q_3 7~$tt赔HwTP7Gι>Qq;%@ȩkɵR^j:%ŽCqpdT'i] tO_47Qvw1|[0UX;ypr vOڗn4ugiĒ[Y[4&!Nۏ*N=I_%3i>Ynį6c@SWO xGԼAg$HvN&,xDFnAr;zcɒ[8RT-s|G ЅdbB9{O"T̮1Ν)y:iH%XPjcqoxT&4y~LX|:B67JqTCPZʸ=nBfܮ +*4v${T+[}s֒7⡷!mbPܒ;_R!̕TFyu'vB~5񥊁@R@̀ $cօ$ +r XqOt 46FcZBJlzƠPE652;umJb\;:0cP'z^曞hԔ: Z(((((m!4R/5Gx s]G109 Q#'ְddѐ0f8ܮXҠAB[$1Tp~N[c̒THVfƭˌz;m -A$.!tiiTe |~ξs<,>iW eެ8(~ZAMc@C 4nS?6j)%Ye۱sVpmU`%#ހ4`Q9 ㊂T@5Mp3/SK$g%>UHi;tBxBaވARi44OB%nD !#vޕ-bėNNk5/4}81큏ݜGGm^dx_ P6w`QpzЎh:bPsr*=6ɠ ` :1\8WQ Emw4gz(PZu5iQEQEQEQEQECN5;k)/kd9!څ?"BIUiI2׵tM"{tBvo_Wf␜Q["Hц7gmek(2X+^j[;BΖ&0#@sp0C Sհ~끟S׃ZG7n?6?JM»M6W4.]y@ļ>Ϗְ":e?ʀ94[w'٪W.X5]/ᴳ̤x5PBt\poK"6RiRH!/@}}nn$]rs@b%mZΊ+g0UM(~)mlmnessr8&k>qJ${˗-4boj͵QH*@3K2<@&ѫ4} [@\QV.hQ})C8@@ ݱc%Y_<[v6涭mr9i"D(P5cGf2JRO&%hqh5[ºFJceOW\@k vN~BKxyG[ FzT]sHp8s" mP6 ؟ƻ)mȮR)|5_[񶵨3 ٹ@"0v qG޽i *5c-lw,2Oޚ>f; @JE7wA "_u~+WW sP~Pъ(iiZZ(((((m4ө /-ckork?v`$9>rk˼U}/|j#Mӊ]7(q\OS#djZjF0aPʖe$gMpIGT4;߰k~E/U8q +\ݛF$&9c;QѼ=m-'d'oPGYdʽ#C .j_ˉ;X851 x@O~A[gҀ8g z4[B>r9>.$ EA$ӏjuHvZ{PQ8xړ W9X G_Rn *7X tɠ u-4rKE]=jl~)%ڻ"3QK,gʎ0n9iKy+c8Y"arxV6*cY$⽦ĶLWqx*[k>0Qwx~oo@#M&5$gUQy\!P}_?<(VCX??ږ6\2&['1\SΥR[u2?xPh`m;ȾXظ=)j %3Vt&Yt^u s/U#%1qZɹHǭWԬHZ DmqPX'1E<1<IugK/UI#m1_o%4oK;6»Tך3AɁsֻ'V/ M0t&eqԊZl֬$x}kvѷZB@&x ەH8f:9p{hJ"qR)P4̄qv'O3m,^nQП1@r0~'׏kT{0F){v#skԴm. D-I-aHP2Bd^sUԯaҴJంB'jcV|l>klGT?@$BjQG${g#)>6;N擽QE(KH:EPEPEPEPEPE!ݮk! |Mb9J*HD* 7PO*ErV,jːc8e181\҄F8=4y%Ly 4t kD"og|Nr '1r1RtJO{g Ğ_Wpۜ@-g:Ml6F(ܑm-S'.5="UyO}jټ Y.rQSҘޝ)dkLPMJs^[~7-YI0V@:g5_}.2\Ǔө@?;ן|JL[Y6>^>a̹5 ntm2i|!ǒ ϯZhWli<3Dž4nViᘭC e\{z힉xX~5ǏexW;}EyΙ#NlUdg1ZiR()py}.~43~0F1ր8 u$DKX+%9ӌr窬F۞j|o!_fv+(qw]H -I$R:Wh}=))D(cҮ6 qq^eȦo h%ležI*w9@%[~T|ʽohM˶y> @N6H%On^Z9sjGq@?1d873^+)(n)@ 'Nրcd ]P YW, *UU}[:Hƕj="-cFlSJxmXOc?SX -WŶ< R& uYzI2H[Tڠ B>B y+_#lh Sz}@| 'x>9뙅zn|U$z>z\ofT>* R& h+f+)=ie3?|-@F;ySџꬪ4/}?s+ӻu#<>u|< =~lw&_93ֽg FWhȻA=8?ZzE#piS=h\QyI0W 6 FI~=({~8M$kg?; ^_xM1PBJN@{17[2XŐ=w/ X~*[u+WNZ<FAրjpk7Yl(2Kc #d([Ĭ!k]@C  tY;Ss\ֻ ۷hySk(; ~tG8FL6hY oYOx~Vw}"QyV gޮnk]ֵ a+6uwa_Wvl۹ q? iI$ns۟@+U sY>:g4aVYa&7PIJA@ ҔM{Lr۰u^@iE'uQ@ :QEQEQEQEQECKHs@-s,eKXIn 9VExnd@2t_31; *ц^^ȥ!~(T=֘:S&)R;TXfH>c@گKq@OӆG S}zܨS`A)<ӆ$j^OէyP&;+پ*i1ף]7 qsN=_22xD\a7hNYzfP)11|IKh} ݲAc09)@Oj_ k;i^-a¡ yHNz0p~*>'e dXe9}9(o-KW# roh+9S JzzRs-8ڳ^3+? M'BE!]E] #.Knwy؅#*d4eFw(+iwˊӍ1ڀkVKΑ40$gp8B0Kd_݆C2%Ksֱe>*꺠LZiNG?#6qƵ:vuL2/V3Z sak׺5sHrOo@qQsEƭxg48a 9Ѵ nɎŹÒ0k韍ڂmɞXc8_?|>v&v7q@DQB8TsC3n@Rm4#.3ڕW'm8(7e݉37 u,wD4":P9)Ph3E%֖u(((((ZC@'Yr1B8}:,F*AH]/pKI&U#4 i\Aaj^M$7/#v3⣌jRQ,R Uǽwdž4J43#ax#.Mmm Uq=qOiW^.RO l3*s* X^mJ0fM3`ysǚ ^XDfF8蚆ehY+@VDjE(bAFi#Z^s4|?=),{[8-'f?=Yq@@2d|hq\ljۺ$k gs#iuGHrH_ 8E&  E,@ 9n)6MajjRڙf-&I .B 1@ߎmTi^kwJT2F|+dhT `v4'Wyxh K/_z0x4_Sƍi Ӷvl!pq哲&soW+ dmH;њJ)qI@-QEQEQEQEQE6Sk8B}3] z9{R(AP}7$P)Jtdw9@ c~9F{ޚ#4'RRW^U<14S1߼zAyǪ886)rh(_J;⎽`3)ȯ?t4S+}O@?<}?_E PN@`܌|Z/γkx)";"2[ WoŻ2>m# ?+[w/OIzr[^;ʣ8 `Nyx 7精 %{;k1S+oqgO>.2n7x *dG<#ה?v9.Կgyˊ O T`nG^ Z?3U'pL&D/W(դ'U\#fNxϯqk־zi7GDA[MvK0%c$'g=K}+LY/40errX/`NG^Ȥl۶ OAW\ j"|S/ XXC$.#ր.&[AF4q`EY-) ?l摛`ySXn\Il{RvvZyJTp9:P]XUfb2X yb S@H>($kش;Bc!yN8#'#>OXmOxhHGB .!OIiN&;IncTf*|xcw8bB"DP`: 4Fyj-eTPHUT I@!H~$kC-@} ǿ~6ң$dc1o_>Pf {5Yi|#XqŒ T6i4◪P,rc暋TV!yucb@XG]7~r(vqtdm4M@ E%֖iQEQEQEQEQE1(|[Fk'ᣅHlVdP@$}*m{Qby$g'9r~4Տa<7җ$uGLPy5Uɧ'o8(=;xHQv%ovW{9^Jn|[r[~N#g8ǩօ:IJOҾz,V=[A/4Fpsa_B/S^KB$ڞe~m'%W6 ~뛓ytRȅ(㜺o *;nݎx`'r@.ѿV9+U`[DhٯR^a~f1ntרcynU|qyqΦ.}23~'S`U@f:_kF׆uͦo&NzNԚεt[VAͼE$3[5|;xoe\B[Ld# Jm4CֹONiJ֍ Y]^+?h[׃V΢wlUF8# _ixKO]ʿ3c k';x_k$hkn 6T=[?{94Ct⛸' @nlhOpzQOc;HU=ዮ:+0Yy+kL=i6 (zө-QEQEQEQEQE6 f/]9slFvqy uK:afW`K LW.rt c1^@ $JgZ 9V=zNߖX7A) 8/ҙ !95,Km(8@?4 O1!q mU޽5ynn~/Y5T'j974Ҁ:#?Mg[[=vDvkjeXL]cr >WEtnX|QO=8ڽpk[Le H`0YqyCY©$&Ś]KlŒM t l ߊ:mΟe&c+Gg2;uF?.=NQ0EC{[j77dYFG^܎hsa|w$Dڡ`V+pht-O<]g}#v]#ez۵y8#hAX\k7Zjʋ4>LD9NAp:#ㅁ=<闷OE$R`gRB~7؏Fm(\cIkC)#,Se2GNs#>a}a Mt*Yr@lpzb+˵C0, }!UWd9l~>(Ɗ*@(>AVv,*f\#J]1.r)SO,0yڲkO Tg %m͞zޕuMWb!9@ HW4`^Wדx3]iӞO9Qsዯ ̺^h-Á`=€=@V(d% goC m㟲1b,Gw~5ZXMx{txмϖ1UbPgaB;Oamږ/ͷ9}3ڀ8~4qn_lO11S>{lް暩L~~͞fѻnsy#1&$ʁd9"W ր$ frys=)f$BMz6c8@VPf;`fNSҤEq`J0\piJs(bh$0?hx=jSQ?|I[Rhˌ\+o\7kt36{+.kR%-$ g$?2( kLڪlœeI5)Y dă4'41@ ^ESiR-HkOvd]z OZ3(i)hiiZZ(((((m!4>nX>%?my&~4#F J:bJa:HAPaq=zS mGP|^<טxmǷtW/J;AE%(IN@CAhy-R$[d<|0O<ڹo3Hj7=: iʅ%dQOy@zW_ܜdR1N2 LK֦|=;P;sڍN&U#U$V ynͯ/ ʱ3oy?7j63Z]D*un~^9~-xoݿ{WǓր<>Xmd7g[7-4 gv cIGd0 @v.o/tu±NT`~y Shɦ(g2u44Hl1d3 IץE)vP:P8╲#Ka43Ҕ Izh,C 0'?jaN=xsƚWfA!!8#${]π2𝖚#eI!3gpn*Fc}/$%aC =A@ JNa<p_ /zڧ{ͷsW)i܁B>ۊƽW$]'CҕdIrG9E >; nC7ATv2lʀ=+z\i J4t8g.)dsSnhHS]:J}~/>7;w(iiZZ(((((m!4ŏS[?E6NO)N/4)^AE;}3@`tV=*N0(lRAdiɂh?e-t p?y^5>1n,oL½ -(KIҗ4`)M&BkO[.^$jok}檄 'ÀOD|g_]#R€<\\[boWFlen#KcЍpA^cmڭլ,HWF888?Q@A˴sKqF\sҝM? s@ `="A"sk|@ $jM0 x9bG_LOqM(\|tR@ ۊpzT4*(4/1HTqB}}|=uoyvdYX@s[K+[AҦǏ":I[TcB;xpxWz{%L.I>+V0)@45 iJh8h-C~6Pgdn6Hy9_/[GypDNWx'UWۂ\k$#H8'##}Mz_tiEē)<$>];|#75/4M^ M4L\__ )O=)p42WCEs]K N'zZJZ(iiZZ(((((m!4?N"j!ɤ_iZɵQi =7nj|`Uw?;SBf9 ԮSqSr;@ wIz`^[ 7PWર'9'kFq@zc(&N)'C>lcO[&D\ 8@{ٽ'v Ko cgŚg+q\ܾDtw=5ҀXbzH^(AFGs5m4ԙ3`n#>Î\rƺDk~id&(o8ی/-RAi8kD73nInA^eemkk1v WWvf9#C# 3q֣LN]B06۬73P2r:R~Q xoܤY(F 遜{q{:λ˨Y$308 y@wP1@Ӕ"ڈ3p84hGzW)ڋX9T`PPbSNcJGz9[+Vҝu~j9" _]i3^J" !>'źͽ3_X[ڔ sפxs@΁cبD0]9'\O_7>:ğifm3FX`Nk34Piؠ)PZ JqkȴyWvleRǨMJJIs;Iby<Қe,$h HGʠuOA_9h6ĚU+-(z_K0e\KPR,d-Mi ?i7n֙L"s(mq@ӥt/W8GDZޓ/zZJ(iiZZ(((((m!4/tQ~55Ƚ9P V0TOx:#z 01lgjUPT"1ULBS?n 6w0|W!?W{(4E&)Ê)(OJhPh~3xEM4n"4xRTָφK)Cwb|v~^8a|J&> r9?zSJV$FVS <\^Pd9߹wg0w~!4 K‚VA(b1xa~otgUC꧵qN^[q6# :xs*u}KFtBhttXcmYdp9՟\5M9#Yŏ n};"081Sh^5xn了 9>$ZR8QFT ̀2}NKXF(I䚘nSh FQɦZ88heܻ}g(*EMt(2=(#m59ܜ0M R̪@nXZ◈VbxkH䜓 ¨P0!Q@ SE%! m(4+ξ7_EgW-y<0FW IEz9 _jII׬$ҀEIA@ g.9v!cE{pq\ӂC"xoZkAC7({qJZJZJpKH)h(((((78lX U@n1L4R14f0tԋ)Jj(O5?i?(G o;Cx Xx{yvhA#X;N>S.-;5 /TڷGvsc6+o_ڀ,R8 ]3S: #gRq" (R|WC]#/_ʾn{n~%lQJ0F;+h_ =h y '߄ds@ Mhy"5,TS<@.~(|b4Z& -;߻vzgú貱4뛣E³uٯ oV΍iZC@Xz - #v2qeo&$FC1BwaߥzVxmXl3x<MKmhF=&XlcI= _|:;ѭt]V6iw!$I#9]gkgy5$$%3)k"6sjCT.#`:똀8%~\-O~$so4-w5ĻZd #|ӎ|N(🍼T|7_Z+j>dR'*W!Jݵյ\Z\Eql8ulR޼9}:oK~XushI#f Aη>%x@1"+5 x = K%כH 3T}`R^7}*:}j/ =W Iq߂Ó~3vxP6- ֺ<R"#c@=Go/  'GC/[mυ|ǩjvuO 7/v%9=h0)p+˼57[$<3q&K]:a;TqqJ>.j~ Tl6T*\39# >Eiqk ̸eW| )99-xZ:'fS!O*5vgeqE{%E{{4H$aNrzހ=Pa_]ʹ<Ry8=x?M^#'6!ch7fymTˌ3Z/*|? 22\ݿ^eKs@5M=[czq25jr-m]@{fK##Pq2)tw?+:,x~4ʲTT*p@)NIyp@<K??mkCj蟚 `A@^EKڸץ*&ߛ4~b=o58KHx8zKσ[l~:ޔwhhQ֖REPEPEPEPEPiI@ uk_d1"slAf TRǃLkk @sR"qKʿ}X)9q4FC8RwV?AJ"`D[*Ak);io'4[.:J1Sw2-}?RFɭio3ĄHˀ \8F&Ίi^5^.2lP09 H,WZzpamhU 3!99w#iysTЮo(ဒwV?xSSݧu ;.6Eܠd|mFAq|I|/Ǧ5Fk}nl@ O}>%x·B%l}6dF#X@FK<^ 5)]X=A)t N0TOf6VIWq쉨Mq2BVQ s!j>񽇁$͆o{i6I'o'  ׵zfšiKl:,m;1 6$ $dO}^M޻ *ڴhC`98W>I/'Lu ˜dQfn@*ɝ^0.-V25** uoC|?i[͵K,@O|GY|;+Y.59a>\2Jѯ2G 5xG[_Btk$ҜӚ=A>0lP>.y~Mr2vU+[>05֮5;{{հ]pNA޻TzWQ@/↡ͼKk1GQ9`bqrp+3ݟQ]$2PF2 <>n^KCj|2l{s ]b\.rje\,&:tߍ{FXh_E4([M4++yE'wc^9i>ĶEJOZtcTY9KW (u?DҊxc\]mE[b%h`nRú-ÖU3HwFYK<0Q@#qJ^4"(-o*J#OφkO!_5 OC[=hsKcZ(R Z(((((mQ@#@}#,?)찎)E??*KXO( _?~U6) Bmao@z"j^)@Z?3y+_?ew4jW@uޫ2Am 8v0qXdh4IP{q_/A}.|cq{mC ]: S0P7pGy5KUYv 2ղùs[]xOѯ4}oK1fщcVWg^ "|&w/3ʽ<>>up&^+FX[n1Ae284xcTVVJ' WĖ u% I,kG g R+Te-vzGMKDVddFTY؞GsYE Bݼ=iӯKYC~=k'4yyyݮg$1d$z?oEPN}r-nBqJ9,v 5:ͮ~К֒2ðN#1F 29G4u[z>d(Fvtz/X:_+2%HΜ$(nO'U/\xF7\_0K7I[ *s לw{x_\R(Fvvʪp (xh xxt<[Q mW@$_VKi[d6FYh}Gk3Hɞ/\}AyiZC,!>PI7&=21Zi𽆍|or cRٻFd`cᇍ<1̒bĚG/ O 7^͞sG+|Wǟ[VծӴvxY%I nkq}x3Tm .,J c9a2Fxt CߊOqqdr&X z4'<^UͲ pAL 1Bz{Zotj#syZY  z"/"#D̶֤cu䍌pXׇj><i}ZA(k]9k³]ψ6zIn6cklpɓ@BH5꺅PMq,4Y8QҽET@!=|7+_:i"hh%\|I9 mȿjFWs\7¿_ ^h nBx2'61+du/#3W)m#—UHtf>QIvAϧ*+_^ WJ{L#v'ӓ:QKG"\~&xcvz8|=y#§]GZ循q+b,@PA@9zU*tb['Tv?N]+V(iTbB5z+|L=]cOq<8*߆²=R94JF6,+ /t -u^YZNlI13)pzk<3IRUAQ  u`rÎ#WԬ/ -/QhW ,?hCf0;X. ww{P_ ɤ2ZW U\ ;֗;h2~Y)4f"e*ɂF3U>"xO@.l5=f{e ,%ʆG֤ѼwLtV)mrJJ9*@8=P 𕗂9b V2K3YV t'o| $Z 3aPx1Zo?ร: B[BAzd=b<-7{hJcbփs_UѮ%{;|H)[#$8=k>+O7ԦSG,g[F1mH߳o'WNӴO`5Rxe9 +( :s[&Ѵ^I뱘!`r8@z";T d<+l.-&+v|]k 6WWehO.(xUv_B2)8FQωkyyvumQXro݁4/wj"8,Ynt( |3u R̍7(8m)f &mQ*Ոs^Ax'_EaO;uJoNqLשf}Wz>rT]Nป:iڇ6r[c? ]}kO%s[O5 }O3[5L0?cxK֗Q^Ciǂ'2ou=3ռQzщNqjB6MSLDec\6s$:hKrRrc'$g;R$a|6\ۤG,$^ %b#e +h4=ek( ǚPn@68]qÿe@~`]I]#!t1msNf;[;xc$ = I⻛(u=Ywau!N=*&n+ͨ-R-i'|>006Wkf%JHFgR;GN8|x{E]),1Jc?!@W:᎙{ 1y|*x/ZeɗNH)bso>bNz׽&/4p,cLWn;_[ifGHچ-~{O{\7~bP-cy恨Yp9qn3_Hi.@imR}c sU;@..p1 {x5^6KEYy&=IDZtf0řKӴmkmrr#@kFIm:B¾V3l:Ei2YXidU9P0r욏 FsD, ^RH12/vIoNt0%U6Y%<,ju'ko F'4e613 qE浶A dP4_m]-Q(0v$0ڹOiUX,M5 1db#Է~/-/4{ {e Rۣ,@ 8Úŝal`Sր<7 .ma.uDHvƃ6H$6Io7 .E-Rc=h|5`fhO8NAWQo6[đA8*J( JZJZ( ( ( ! ľ񏆴c}i@bUQ?f dx[ú ? *Rd'fF'!N+rާaawyoc<LwN{U-+^. +YF308V]yc/05ǘy&ܯC4O|F,d7rqp0t -5-f)UnzpO:k>di4^FG$J:O)OC rJEtAecр?N+?-Y,a]8R}a x-&\Ӭo-FOFr!''֕Ƨiq}m E Rr _Z |;dIokҾ$:?&Ogww VqQ0vBt\dsX"naGC\qHw?)m([WNPY n&X#4u2[59m"$I:N`dμ'_K~"a#b/m=Elur # rpI9aoͼ6dkHVbq#9>oxuY-C7Ϩ#gs cʊYYp6ryO;@~kz̈́rj1)(sl`He+y ;~P#V[u)6ԡw Σ|EhZ`sΨ}IiˍVFz{w3u5 Kp]7&m~[_w|qCrhqY9FY_JV&2.4(̨Xz{Wz A\pb6 :1BFw8u~ M=מ`3.Ioh1LxSRCEo ЂP3Y[npO;Awymal7ۦ7K3U<H4{^,NڜR6Np\m1M37zq[Qk r\Ù [?) *z_KrJmoc_mWNc?4خ}ܠ*^;R-l'ͧGqI9e2|! fr;rV?h= e q\,F#r oV~HGj-3WuowאC_/R,uiMgoux#3*#Id /v ֚֒5xt p ߍ9pHv((hNAcE=N5cK:ӊ*+̵o^5[RCnk{9cH㝪PN3x6jz^yrK<NmRO8@#umm[9xǩ󁞕CŸ <- 忲w7snh]@P8'xzmW?&+1yfp;W]@>xKZj<˅KHwNy֟ <cj:UQf>gۓ'<Q@f<:mfv{S̄l3I9z TCDMBe/fc!*ۆ@c/w YKl.7~TxSD5mCUӬEKyX8b@䞀T OvΑP,2t" 崯j7<-]iyJv7 0sK^zc E=ivgw}'OZg8Qp^ġͤ\ Cg޻:(ҾCKΊle镮eي&08'&. [xvNߥZ g0mǩk XIzھ{Iɧv >v%5][Ok4q[v?}z"ꥎA@+ŗ4 t}B[efkvU| ޔۏ Xx,xU"lU qzcڷ(657N4DGJSY_nv.=56Z],O'm9+j(o xNKqw{rHbC<Úʓ7I-/ip3wv{8Ez}_|EXIg{') 29#$Nrs<O7)seCTqLր|t|!h3bXۻx2xP!Dܐ7>GXu\| }5l5kHc"8b鷿mgMswh:&kn2JȮdzt#*M;ZV IHeオ8y+ -DxzķSN$mj+-Xd rOskwoTMB}{Jxay{0='@|tVz-̅SCT'*{g4^5w7۴‘$>F.nS^$&=ZMIK%a̡=|?XgBuR{bI,ğRI>sWá|J?'K bF^_x:NځN+/Bmap$)N1Wl~i7O^M-̟͘bC& 9s@M=+Y#(u$Bvݣ8$9rIicdO@+̴6oWtȻFŒ<B/Դ L028;Xp~>\U|AB|MmC ]@žv 6xS u)KÝ.Z z}|4GFzE{TQx۸ qe5h'.``ngڀ3l3w4jN_s.DV$Jz}}9+$I?xwY}F[oiQIĕ 8oxoQ G h|ݛduF:Y߂dӵF[v%gֻh ^]r^Cs90ɼS8UFӜd`V^S\94%eX<ݏA;xLMU-.Ȇo9 @̸y&>㶱aڄĺYT.GN}y+\j:^pVGXH`rUS"o7K2O"ͧ1AjK p ycXNju  - 7`)@U[|=^ [k[k)$LrpY=ut[ggۻpѼclӜ'k5 ,X,$BI'i69OQ6?g|)ᎴoxkFƽ!DK s  ⱓ\վҵ۽;Nӄ։p ` ױt}:@yV7]{?.>o>Z>4uFFW6rZ[Z1p|lo5GGoZj/&Lh@[ 2Sx?wیgWkk*o<'iss< xkbo4~ǂG,FȬN> j2Ki:݆@HE^CrNG1~ßYu[Oe)+?񑷩 w';+_:!2$nڻ#ᦥm{)Q6IڄW2XQc O7̓W+opFWq1x棳:o">z 1ݓʅPXT7C;t_iDjzo?f4ݤRmv`K.\y z;z-#P6 Dk5Ƙ Ǡ`9& I b"VL :?kƵ5fIiك6QH7{/ WZ/tv7YeL}2F}|ˏwt wSL$d{E8 qx/7о{jOsprDzNWߴKM|Aۥ׏jOKO'z+M$Dr׮Ҁ ( ( ( ( ( ( (uih(((((QEQEQEQEQEQEp ~fc__3^1u@W ~3.ռ_{]q:I+#9B#8Ec:7c>o,$)-q# ] |BD[ō&*H@WQpIwa|Sj HPcfA!Wq989@S"Kr=4 |lAiOuz| ˆتpO o|8A^@ϼ#o `=QPaT(|sy j{!)AX@fz$>YxῇtKݣK:tqKq20} z>&sZ~-<~i- xaЌWҵ _Uv.L"3 >^R5M-X)r9 Oh}N &|Gյ l]#,:w-I,X .1WD}bD/!y\$ xTWx z$UY'7fıT<@uڊ%͗ADGP-^'OU6T^Dr]_Y%,v`#99$'ѵw5Lj۩c)mkɼ={'<:4f%QY6pn1'[xvv&5ɸ)}W#uZhTܰA$w'{^45u[yaxoN8cY 2n606 +)mSP &"@.wGv Ww'to 1g]I[G0tF/5T˪x1 b H99砭xľ8/-R}3\\q#(P{l**_#Ln͎g=奻q`.E'*s\f=Nmo yW r;8F{WYV$_ 5BT7Em4I:av!z 5/[ZׇR71EٴͺDo,6 dk-HԖ鬵+k o+*]\¯Y: :ҴHլ/~6>PS,3pAx(|ZsZ _e,X9|ӊ>|D״4e<3}#Hj!\h!UGׂ>;{;y..#R,T"+V(ȵՆk SCtY`0A hh?O^^]5)s@Wu?{$^Ex/W<;>zb͋#hp۷eGjGn?kMk䑤SI$pJ (45ߌ5V K#Cy|ds ;9_ZMg-we&6ڻHc#ݺ֊Mwᇌ|SIѭt弛ZjU_>?76Y@U+UA14#Qm,!q:EFO#]'>WZZ\l%[[#ٸ LxO 5 \ZIw~.rDc_2 9PzxH9O>4MF yh * _ 5-c@6ܳ峷̼s!NO@JZ(u.Sd%0.ѹ86<?J?oF`ͳheϙ^Ps5MtlN%VwvB< Xg늗_5ΈkMgyr<;N8V~n~ u#Iܸf$s]uPEPEP_;6ih?4ڍ@I~\ѯ]q hOPEPEPEPEPEPEPEP-QEQEQEQEQE6(((((( u k:h"k~pYA$)9Aɯ1F X3^ xUXrŅʶgsӆC ]_% ghK 0ePC)ݽ|7vx{ RV6{j U1s+ Yx;ז\އy%ɳI$e&0p ͂{(׈<:.] $y_wcC7wOeo3KNm O pkSS\l6&9i"CR z݇& x>?կ-gM݈-:T,$T<Fzvo/jZjO[xXɌ7gTo KҴ#eG&Ol3yž8Դ>-`{MQL\ߔq yޱ !Rev$s>QZػ|w⯈~t #`X9<ǯZm+ƚ5 hFq-d0w?g `c/⿏5 Zi,tGi6"nF<'_O_iv.˩te=*Dž|hsCMo22NmCN&C>۔k?|G}ۏ x7Lk4sqnqJ1k$ѵ-iw XF8b]^xLεQ`gX2Tww~ xZ׾x+麅;*02FT#NNj 3σ4;1d|=6nG.<1+qC M:$t؊%'{8x C^MNH̶*|wk7-~u 9}qx|Y/hA>n 6L'vwtVi0Yۢ B'Hr>i>@xn=556h-?,1e*ϥlY|Q;Zx^LgmώYzF3Mc_ ɧhIsj;×۱H8;UgZ j݋ũmxۖRX0Qq#q/ˣ2f *%?7?&~%V1;qo9eRX8zu׊O{~ yvyv]pǸǺ.wڭ-f;,)v#ir1WX"O jj"c3*9||g?yWS X# j<_OVӼ~|'[QKuHR-?3 00@xq׀|Kq‹]qw%3#9!q[Bn|$d̷Kx$ceTEz/Ek}4,d!!֣ީ5ƺ~<&0'`RANќg{6}swז/aqW r# \gs#q]QEQEQEQEQEQEQE(KH:EPEPEPEPEPh(((((w]qZcZ|OݥBMGJ;tp7cHߴf]B{eӁ#_G4B/P^$?h8;u F.B{m?w _G4vB/PQ^# лu w _@Ex4B/Q !лu WG.B G(?F a3/PQ^# лu G.B{u?w _G4vB/PQ^$?h8̻u Ee_kX~:yz*Hhm- +28;Ҁ=t6|NN{Ci/B{EC]x&u*UO+-M n9sc{iQp1d]޻NvsSA`t]@l&l^9^G [h;#j'fnْ=6?6zx+c<.bC.,FX`p2=)|'@k(h%__r=j_h ;[?%@oE(֫ .?uMa'$z}uR~9LZ@jQ(''85~9ߍFaU;#I4o@PGϨƻ>AsoE[DVM#; Wo@Q@Q@Q@Q@Q@Q@Q@ :QEQEQEQEQE( ( ( ( ( ( s࿂iVm>w{c.k@9 :W@Fgooƨvu\<~: //7^Ey'3DŽ#UtP;K:R;xG:WQ@=?Qj6L=0sOuV=aXX^Ex<7.[`iξFHp:%?LEvzgOl~4g M`ǃ s9^Ex3Ag=HMoQdQI{5uߚj+wG;=ޚ[Y d<@s2:ycg+hx9~ҏg}+hw;~қ v{=Κ7oR9i^Ex3A9i^Ex3AwJ7cEsw}{}l}Gf(kjUQ:((((((((GZZA֖ ( ( ( ( (?٠Fu`5.꿣mJFIF``C    $.' ",#(7),01444'9=82<.342C  2!!22222222222222222222222222222222222222222222222222:" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz)( / 00DArialngs0-(0(z[ 0 D[SOalngs0-(0(z[ 0  DTahomags0-(0(z[ 0 0DWingdings0-(0(z[ 0  A .  @n?" dd@  @@``   #n    !#$?R$qNa9OpR$ ˃:qL킷;R$yT%X{YxYpJmyͳ 0AA@8  3ʚ;ʚ;g4[d[d@z[ 0ppp@ <4ddddl 0- 80___PPT10 pp#Antiarrhythmic drugs  OVERVIEW the heart contains specialized cells that exhibit automaticity, that is, they can intrinsically generate rhythmic action potentials in the absence of external stimuli. 2 k INTRODUCTION TO THE ARRHYTHMIAS cardiac arrhythmias may cause the heart (1) to beat too slowly (sinus bradycardia); (2) to beat too rapidly (sinus or ventricular tachycardia, atrial or ventricular premature depolarization, atrial flutter); (3) to respond to impulses originating from sites other than the SA node; (4) to respond to impulses traveling along accessory (extra) pathways that lead to deviant depolarizations (A-V reentry). PPG ?*Causes of arrhythmias Abnormal automaticity: The SA node shows the fastest rate of Phase 4 depolarization if cardiac sites other than the SA node show enhanced automaticity, they may generate competing stimuli, , v (Effect of drugs on automaticity Most of the antiarrhythmic agents suppress automaticity (1) by decreasing the slope of Phase 4 (diastolic) depolarization (2) by raising the threshold of discharge to a less negative voltage. ,  #Abnormalities in impulse conduction/Impulses from higher pacemaker centers are normally conducted down pathways that bifurcate to activate the entire ventricular surface .A phenomenon called reentry can occur if a unidirectional block caused by myocardial injury or a prolonged refractory period results in an abnormal conduction pathway. 0Z0 ,Effects of drugs on conduction abnormalitiesAntiarrhythmic agents prevent reentry by slowing conduction and/or increasing the refractory period required to convert a unidirectional block into a bidirectional block.  Antiarrhythmic drugs Gthe antiarrhythmic drugs can modify impulse generation and conduction. .    5    CLASS I ANTIARRHYTHMIC DRUGS $Class I antiarrhythmic drugs act by blocking voltage-sensitive sodium channels Class I antiarrhythmic drugs therefore generally cause a decrease in excitability and conduction velocity. ,AV Use-dependence :Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing. This property is called use-dependence;Z;g   Quinidine  Quinidine is the prototype Class IA drug. At high doses, it can actually precipitate arrhythmias, which can lead to fatal ventricular fibrillation.    Mechanism of actionQuinidine binds to open and inactivated sodium channels and prevents sodium influx, thus slowing the rapid upstroke during Phase 0 . It also decreases the slope of Phase 4 spontaneous depolarization.   ActionsQuinidine inhibits ectopic arrhythmias and ventricular arrhythmias caused by increased normal automaticity. Quinidine also prevents reentry arrhythmias H  D  %Therapeutic usesin the treatment of a wide variety of arrhythmias, including atrial, AV junctional, and ventricular tachyarrhythmias. Quinidine is used to maintain sinus rhythm after direct current cardioversion of atrial flutter or fibrillation and to prevent frequent ventricular tachycardia. t=  7 KAdverse effectsA potential adverse effect of quinidine is exacerbation of the arrhythmia. Quinidine may cause SA and AV block or asystole. At toxic levels, the drug may induce ventricular tachycardia. Cardiotoxic effects are exacerbated by hyperkalemia. b $ A   Procainamide  p1. Actions: This Class IA drug, a derivative of the local anesthetic procaine shows actions similar to those of PharmacokineticscProcainamide is absorbed following oral administration. Procainamide has a relatively short half-life of 2-3 hours. A portion of the drug is acetylated in the liver to N- acetylprocainamide (NAPA), which has little effect on the maximum polarization of Purkinje fibers but prolongs the duration of the action potential. NAPA is eliminated via the kidneydd6 - gAdverse effectsWprocainamide causes a high incidence of side effects, including a reversible lupus erythematosus-like syndrome that develops in 25 to 30% of patients. Toxic concentrations of procainamide may cause asystole or induction of ventricular arrhythmias. Central nervious system (CNS) side effects include depression, hallucination and psychosis. XZXZ G P  3N Lidocaine  Lidocaine is a Class IB drug. The IB agents rapidly associate and dissociate from sodium channels. Class IB drugs are particularly useful in treating ventricular arrhythmias. Lidocaine is the drug of choice for emergency treatment of cardiac arrhythmias. Z$  HActionsLidocaine, shortens phase 3 repolarization and decreases the duration of the action potential lidocaine suppresses arrhythmias caused by abnormal automaticity. abolishes ventricular reentry. H 5 + "Pharmacokinetics\Lidocaine is given intravenously because of extensive first-pass transformation by the liver TAdverse effectsLidocaine has a fairly wide toxic-to-therapeutic ratio; it shows little impairment of left ventricular function, The CNS effects include drowsiness, slurred speech, confusion, and convulsions; cardiac arrhythmias may also occur. Z CLASS II ANTIARRHYTHMIC DRUGS $3The Class II agents include the beta-adrenergic antagonists. These drugs diminish Phase 4 depolarization, thus depressing automaticity, prolonging AV conduction, and decreasing heart rate and contractility. Class II agents are useful in treating tachyarrhythmias caused by increased sympathetic activity. 44H{     q    +   Propranolol reduces the incidence of sudden arrhythmic death after myocardial infarction The mortality rate in the first year after a heart attack is significantly reduced by propranolol, partly because of its ability to prevent ventricular arrhythmias.  E!  Z ` 33PP` 13` 3333` Q_{` 333fpKNāvI` j@v۩ῑ΂H>?" dd@,?n<d@ `7 `2@`7``2 n?" dd@   @@``PR    @ ` ` p>> | t  0 (  0 0 <䉻" H"0C  0 Td" H"0C  0 <$"U_ H"0C  0 Td">& H"0C  0 N"P H"0C  0 <"p H"0C  0 C x8?d?"bUv H"0C   0 <졻 #" `   LUSQdkYkHrh7h_     0 0ģ "   8USQdkYkHre,g7h_ ,{N~ ,{ N~ ,{V~ ,{N~    0 6 "]}  `*0  0 6Ȯ "] }   b*0  0 6 "]T}  b*0B 0 s *޽h ? 333380___PPT10.(г%  Blends   * " 4 (  4T + 4 "+bb P@ 4# "Dwoh 4 s *"PP 4 Bd" P@bb P 0  4# "Nyh 4 s *"P   4 Bd"P 0 z  4 <" a*h  4 s *"  4  f?d?"+)  4 Bq ?#" ` p q LUSQdkYkHrh7h_    4 0q " `   q NUSQdkYkHroRh7h_  4 6 q "`p  q d* 0 4 6q "`p  q f*"0 4 68q "` q f*"0B 4 s *޽h ? 333380___PPT10.(г%*  *(  x  c $q 4 p q r  S q 4 `   q H  0޽h ? 3380___PPT10.n~a&0  0 0(   x  c $* 0    x  c $X 0   H  0޽h ? 3380___PPT10.n0C0  @0(  x  c $hq 0   q x  c $q 0  q H  0޽h ? 3380___PPT10.n&0  P0(  x  c $  0    x  c $  0   H  0޽h ? 3380___PPT10.o=0  `0(  x  c $ 0    x  c $$ 0   H  0޽h ? 3380___PPT10.op0  p0(  x  c $ 0    x  c $d 0   H  0޽h ? 3380___PPT10.o0  $0(  $x $ c $d( 0    x $ c $$) 0   H $ 0޽h ? 3380___PPT10.p@S0  ,0(  ,x , c $X/ 0    x , c $T 0   H , 0޽h ? 3380___PPT10.p[ ||(  |D | C A1P | s *޽h ?"` 333380___PPT10.E`ݫ$  8$(  8r 8 S m 0    r 8 S m 0   H 8 0޽h ? 333380___PPT10.\.$  <$(  <r < S 0s 0    r < S u 0   H < 0޽h ? 333380___PPT10.g$  @$(  @r @ S Ё 0    r @ S  0   H @ 0޽h ? 333380___PPT10.\ |(  D  C A2gP  s *޽h ?"` 333380___PPT10.Ebx 0|(  D  C A3P  s *޽h ?"` 333380___PPT10.E$  D$(  Dr D S Ȇ 0    r D S  0   H D 0޽h ? 333380___PPT10.p$   H$(  Hr H S  0    r H S  0   H H 0޽h ? 333380___PPT10.hJ$  0L$(  Lr L S L 0    r L S   0   H L 0޽h ? 333380___PPT10.Ջ$  @P$(  Pr P S  0    r P S P 0   H P 0޽h ? 333380___PPT10.00h$  PT$(  Tr T S  0    r T S  0   H T 0޽h ? 333380___PPT10.` $  `X$(  Xr X S  0    r X S  0   H X 0޽h ? 333380___PPT10.rq$  p\$(  \r \ S @ 0    r \ S  0   H \ 0޽h ? 333380___PPT10.P $  `$(  `r ` S x 0    r ` S L 0   H ` 0޽h ? 333380___PPT10.$  d$(  dr d S  0    r d S | 0   H d 0޽h ? 333380___PPT10.:Ց$  h$(  hr h S  0    r h S  0   H h 0޽h ? 333380___PPT10.$  l$(  lr l S  0    r l S  0   H l 0޽h ? 333380___PPT10.$  p$(  pr p S D 0    r p S  0   H p 0޽h ? 333380___PPT10.@]$  t$(  tr t S   0    r t S h  0   H t 0޽h ? 333380___PPT10.@$  @$(  r  S ` 0    r  S ,4 0   H  0޽h ? 333380___PPT10.+pwRrCE)HaJLN)8 QASW1Y][`bd%gQi}kmor-tYvxz@yU]_|?  !A+( /Oh+'0PC hp  Antiarrhythmic drugsPweiBlendshwei27Microsoft PowerPointP@ډ@PGn@ .G6Bg  !  -- @ !--'33-- @ !40--'-55-- @ !4I--::-- @ !4J--@@-- @ !4K--GG-- @ !4L--MM-- @ !4M--UU-- @ !4N--\\-- @ !4O--dd-- @ !4P--ll-- @ !4Q--tt-- @ !4R--}}-- @ !4S---- @ !4T---- @ !4U---- @ !4V---- @ !4W---- @ !4X---- @ !4Y---- @ !4Z---- @ !4[---- @ !4\---- @ !4]---- @ !4^---- @ !4_---- @ !4`---- @ !4a---- @ !4b---- @ !4c---- @ !4d---- @ !4e---- @ !4f---- @ !4g---- @ !4h---- @ !4i---- @ !4j---- @ !4k---'-- @ !4.D---'--- @ !4DU---- @ !4DV--%-- @ !4DW--0-- @ !4DX--8-- @ !4DY--A-- @ !4DZ--I-- @ !4D[--Q-- @ !4D\--Z-- @ !4D]--b-- @ !4D^--j-- @ !4D_--s-- @ !4D`--|-- @ !4Da--ۄ-- @ !4Db--݌-- @ !4Dc--ߔ-- @ !4Dd---- @ !4De---- @ !4Df---- @ !4Dg---- @ !4Dh---- @ !4Di---- @ !4Dj---- @ !4Dk---- @ !4Dl---- @ !4Dm---- @ !4Dn---- @ !4Do---- @ !4Dp---- @ !4Dq---- @ !4Dr---- @ !4Ds---- @ !4Dt---- @ !4Du---- @ !4Dv---- @ !4Dw---- @ !4Dx---- @ !4Dy---- @ !4Dz---- @ !4D{---- @ !4D|---'A .=<( {{ppddYYNNCC88,,~~ssgg\\QQFF:://vvjj__TTHH==xxmmaaVVKK_\`abMNOPQ/0123\W]X^HIJKL !"#$WRXYZCDE[G?RSTUV>?@ABMNOPQ/012345678BHIJKL !"#$%&'()CDEFG>?@AB /0123456789:;<= !"#$%&'()*+,-. '-- @ !s E--'--- @ !d"---- @ !d%-- -- @ !d+--"""-- @ !d0--$$$-- @ !d6--&&&-- @ !d=--(((-- @ !dB--***-- @ !dH--,,,-- @ !dM--...-- @ !dT--000-- @ !d\--222-- @ !d`--444-- @ !dh--666-- @ !dn--888-- @ !ds--:::-- @ !dz--<<<-- @ !d-->>>-- @ !d--@@@-- @ !d--BBB-- @ !d--DDD-- @ !d--FFF-- @ !d--HHH-- @ !d--JJJ-- @ !d--LLL-- @ !d--NNN-- @ !d--PPP-- @ !d--RRR-- @ !d--TTT-- @ !d--VVV-- @ !d--XXX-- @ !d--ZZZ-- @ !d--\\\-- @ !d--^^^-- @ !d--```-- @ !d--bbb-- @ !d--ddd-- @ !d--fff-- @ !d--hhh-- @ !d--jjj-- @ !d --lll-- @ !d--nnn-- @ !d--ppp-- @ !d--rrr-- @ !d!--ttt-- @ !d(--vvv-- @ !d---xxx-- @ !d3--zzz-- @ !d:--|||-- @ !d>--~~~-- @ !dE---- @ !dI---- @ !dP---- @ !dT---- @ !d\---- @ !d`---- @ !dg---- @ !dl---- @ !dr---- @ !dw---- @ !d}---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d$---- @ !d,---- @ !d3---- @ !d;---- @ !dB---- @ !dJ---- @ ! dQ---- @ !d\---- @ !dd---- @ ! dk---- @ !dv---- @ ! d~---- @ ! d---- @ ! d---- @ !d---- @ !d---- @ ! d---- @ ! d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d---- @ !d0---- @ !dF---- @ !!d`---- @ !)d---- @ !.d---'@Tahoma-. 332 EvAntiarrhythmic%" "#3."System-@Tahoma-. 332 Edrugs""".-      !"#$%&'()*+,./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( wjm;QEQEQEQEQE6((((((}+ 2nRS PBor@8GK\?|=?N(V#0]\0Ew "}2ISR=-?tCf:({[V[?3G#soM[lk:j gk9G5o4=-?tCf:({[V[?3G#(ksm[lk; gk81?y2R4;}prIۃx%🏌bc_Cb`H#']Ywǖ͙}ov78#$ A_.Ӷlb{uǵuTP3/73_3&o?]5fx}/ _ KEs_ٞ1K3?|aC6v@gfL~3_3&o?]5fx}/ _ MEs?ٞ1K3_ϥtP5m7@iD0yǥtPqu] e]/YKXnIUgd=WUiuv 57^2jjKm-LXJ2\B猃9w((((((((()ݩQEQEQEQEQE( ( ( ( ( ( <T>*iizyrP`'h $cq~uO+]Y3,hQc w$^{⟋/a]3_XԾacw/w(z8*+5o<7xPӭ $R5*L7 9^6xNV\an,2sʎ@Eyko5?Qk7MrH# ? WQC+N)Ds;<FOQ_8~${}swp  89`0:WEGËė>/m[}J &8op@#꺌:F{+v\H#TR# şϊR;[5[Cty!검FF<`_EExw#xW1;(oF=Qs\q|M« E5mud[M5(m9<4}%Q7Σ6k31Ly\ ./o]jB/)l$QC98$.@"ޑ'&q[@1?Nv=5x/FX`b2y֥?Zc >E;TŰx]cWϚZ"k8cѕr@995j(((((((((vӻPEPEPEPEPEPh(((((+Wo]GD Wo]GD 袊2 ֢Ŵyr` !xz.goM#eDPAr6$ v=jj^s^IZDKmU'xr|T_8=X|q}ބ?9ռO|7cQF#v1nIp rC WgZ5]*Sɻk<0rU|1^ľ(ί @$KP@y;wLEM5-#J|=|\!n9qe#8 (_>Ï 77r^ˉbb9'8,yޟ"ԼG˯ JOinb +1On5[ApO r96Rw PO,~jV_ >jWp9zjWP[7<rp2OBծ iד,cI\)'˯Z!5QkgCfC ^;ץjlƑy\]S {W(#_ xe|]$$Ko?!'=0:ٺ[i ]B7gؗ2#|zש@w_'hm\o&2ч\{y\iKY5}{]iw>hY(E@A+JIо$kxcֺԌou+C'.$v#Q.}wK~Fe<۰NAޤ5>!߉mmԒ,Fv~էaoema ZtVYInc yB@U>%ƑsU+O׈vy{NyϮEQ Z Ky..f"RK#T$|O𮩧G T˒o^ὧm+aodVc U+׾O|W [ëX8 Ox@Ǐ-.҈gWY ( d z| ipxZ4xLZt6@>qϫAq]C&8}֩xUЧ-+3 sai?|Y%<9a4A-"| `F n,Y[pE4׳ ,!(@ewubjc[k~{,bm JXw~=o{+ CAX'BTO `9ɓ>]xgW&oD6ק-3 qvRuC]N 췰ewcǿ(Cƞ Ɲma]\o}mIckmGnmiɧ g',准lm.tԺXgdw8=fN;N:Eо!|:PW如鮖-I*LNh|E>]w_fH,S*x9q}c,tK-Y xAsU. |/fHU] 3mu2}ՉwKŮieErn`gֳƐw::V &q#r1ާ>,k7:Dn3Gݸ'^ VQGgcm?VJ:xaN$7L{;o 55SOs;{(fS7zr sF0WiPk9G OtϞ6_5NʼnX'V mOΟn'}B%Sݿ?6@ߡxVo x.Hd7QG2Y* t Z!Z u,*87ts+u "]:%cߵ)8by֟St Iyj ku##9~g|i'ڦծnjű}2~ЧK4:[ "mdVl9=3ս ~5}O(t-*8RG2JwH2}2:%^N$+OF 6;gSwRլ?[5XK1q$sUpuozկ溎iӯhǴ2A1< ׻M_BX4ҵȭ־aW'` 2 S/ʊp2q IzNy=F:}'Ǻ3m}XUsrFq2hY|aG 5rٛiYv FWvȮ (*j'Mcu iW`p]ctQ@Q@Q@Q@Q@Q@Q@Q@Q@;6ڀ ( ( ( ( (EPEPEPEPEPEP\/x]p)wTQEPE g"5G-Oc}>U_;~&K'|Oj`öz1(@ꬤz->4<u?M,WwQ@cmpHba@dgҖ~U~5iI/DYdk(Y<Ww{s IqCL& ]( erd~xD:,w],Hq$ GLӼ YK5 ]X,aIsHپ"[PiVZ$Np98-ǒ5 5G \ /cڀ;z+ψ:|@t6m}°nGUs^TD+{hV=eid~GU@Hd/jhկŜkrpHtYzƔ,5 -2yT.,cYr+&:=׉|G5Z# 7kC6;+5 Zycl^\\ 5FS շG+_MGCi[O9E٘X$=#N$j5㿿LVhY/ۄ8ֻ|Hzy^hyks^y At {w4缃RԴ_hzyӈ8 T 5\+Iu ^:x?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcefghijklmnopqrstuvwxyz{|}~Root EntrydO) .Pictures6Current User)SummaryInformation(CPowerPoint Document(dNDocumentSummaryInformation8 00DArialngs0-0z[ 0D[SOalngs0-0z[ 0 DTahomags0-0z[ 00DWingdings0-0z[ 0 A .  @n?" dd@  @@``   #n    !#$?R$qNa9OpR$ ˃:qL킷;R$yT%X{YxYpJmyͳ 0AA@8  3ʚ;ʚ;g4[d[d z[ 0ppp@ <4ddddL 0- 80___PPT10 ppp%Antiarrhythmic drugs  OVERVIEW the heart contains specialized cells that exhibit automaticity, that is, they can intrinsically generate rhythmic action potentials in the absence of external stimuli. 2 k INTRODUCTION TO THE ARRHYTHMIAS cardiac arrhythmias may cause the heart (1) to beat too slowly (sinus bradycardia); (2) to beat too rapidly (sinus or ventricular tachycardia, atrial or ventricular premature depolarization, atrial flutter); (3) to respond to impulses originating from sites other than the SA node; (4) to respond to impulses traveling along accessory (extra) pathways that lead to deviant depolarizations (A-V reentry). PPG ?*Causes of arrhythmias Abnormal automaticity: The SA node shows the fastest rate of Phase 4 depolarization if cardiac sites other than the SA node show enhanced automaticity, they may generate competing stimuli, , v (Effect of drugs on automaticity Most of the antiarrhythmic agents suppress automaticity (1) by decreasing the slope of Phase 4 (diastolic) depolarization (2) by raising the threshold of discharge to a less negative voltage. ,  #Abnormalities in impulse conduction/Impulses from higher pacemaker centers are normally conducted down pathways that bifurcate to activate the entire ventricular surface .A phenomenon called reentry can occur if a unidirectional block caused by myocardial injury or a prolonged refractory period results in an abnormal conduction pathway. 0Z0 ,Effects of drugs on conduction abnormalitiesAntiarrhythmic agents prevent reentry by slowing conduction and/or increasing the refractory period required to convert a unidirectional block into a bidirectional block.  Antiarrhythmic drugs Gthe antiarrhythmic drugs can modify impulse generation and conduction. .    5    CLASS I ANTIARRHYTHMIC DRUGS $Class I antiarrhythmic drugs act by blocking voltage-sensitive sodium channels Class I antiarrhythmic drugs therefore generally cause a decrease in excitability and conduction velocity. ,AV Use-dependence :Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing. This property is called use-dependence;Z;g   Quinidine  Quinidine is the prototype Class IA drug. At high doses, it can actually precipitate arrhythmias, which can lead to fatal ventricular fibrillation.    Mechanism of actionQuinidine binds to open and inactivated sodium channels and prevents sodium influx, thus slowing the rapid upstroke during Phase 0 . It also decreases the slope of Phase 4 spontaneous depolarization.   ActionsQuinidine inhibits ectopic arrhythmias and ventricular arrhythmias caused by increased normal automaticity. Quinidine also prevents reentry arrhythmias H  D  %Therapeutic usesin the treatment of a wide variety of arrhythmias, including atrial, AV junctional, and ventricular tachyarrhythmias. Quinidine is used to maintain sinus rhythm after direct current cardioversion of atrial flutter or fibrillation and to prevent frequent ventricular tachycardia. t=  7 KAdverse effectsA potential adverse effect of quinidine is exacerbation of the arrhythmia. Quinidine may cause SA and AV block or asystole. At toxic levels, the drug may induce ventricular tachycardia. Cardiotoxic effects are exacerbated by hyperkalemia. b $ A   Procainamide  p1. Actions: This Class IA drug, a derivative of the local anesthetic procaine shows actions similar to those of PharmacokineticscProcainamide is absorbed following oral administration. Procainamide has a relatively short half-life of 2-3 hours. A portion of the drug is acetylated in the liver to N- acetylprocainamide (NAPA), which has little effect on the maximum polarization of Purkinje fibers but prolongs the duration of the action potential. NAPA is eliminated via the kidneydd6 - gAdverse effectsWprocainamide causes a high incidence of side effects, including a reversible lupus erythematosus-like syndrome that develops in 25 to 30% of patients. Toxic concentrations of procainamide may cause asystole or induction of ventricular arrhythmias. Central nervious system (CNS) side effects include depression, hallucination and psychosis. XZXZ G P  3N Lidocaine  Lidocaine is a Class IB drug. The IB agents rapidly associate and dissociate from sodium channels. Class IB drugs are particularly useful in treating ventricular arrhythmias. Lidocaine is the drug of choice for emergency treatment of cardiac arrhythmias. Z$  HActionsLidocaine, shortens phase 3 repolarization and decreases the duration of the action potential lidocaine suppresses arrhythmias caused by abnormal automaticity. abolishes ventricular reentry. H 5 + "Pharmacokinetics\Lidocaine is given intravenously because of extensive first-pass transformation by the liver TAdverse effectsLidocaine has a fairly wide toxic-to-therapeutic ratio; it shows little impairment of left ventricular function, The CNS effects include drowsiness, slurred speech, confusion, and convulsions; cardiac arrhythmias may also occur. Z CLASS II ANTIARRHYTHMIC DRUGS $3The Class II agents include the beta-adrenergic antagonists. These drugs diminish Phase 4 depolarization, thus depressing automaticity, prolonging AV conduction, and decreasing heart rate and contractility. Class II agents are useful in treating tachyarrhythmias caused by increased sympathetic activity. 44H{     q    +   Propranolol reduces the incidence of sudden arrhythmic death after myocardial infarction The mortality rate in the first year after a heart attack is significantly reduced by propranolol, partly because of its ability to prevent ventricular arrhythmias.  E!CLASS III ANTIARRHYTHMIC DRUGS 5Class III agents block potassium channels and thus diminish the outward potassium current during repolarization of cardiac cells. prolong the duration of the action potential without altering Phase 0 of depolarization or the resting membrane potential. Instead, they prolong the effective refractory period. 660a7  $  @$(  r  S ` 0    r  S ,4 0   H  0޽h ? 333380___PPT10.+pwRr!? 2!+( / 00DArialngs0-0 ՜.+,0     ĻʾejdN[$A )ArialTahoma WingdingsBlendsAntiarrhythmic drugs OVERVIEW !INTRODUCTION TO THE ARRHYTHMIAS Causes of arrhythmias Effect of drugs on automaticity$Abnormalities in impulse conduction-Effects of drugs on conduction abnormalitiesAntiarrhythmic drugs õƬ 9CLASS I ANTIARRHYTHMIC DRUGS Use-dependence Quinidine õƬ 13 õƬ 14Mechanism of actionActionsTherapeutic usesAdverse effectsProcainamide PharmacokineticsAdverse effects Lidocaine ActionsPharmacokineticsAdverse effectsCLASS II ANTIARRHYTHMIC DRUGS Propranolol CLASS III ANTIARRHYTHMIC DRUGS õƬ 29 õƬ 30CLASS IV ANTIARRHYTHMIC DRUGS Verapamil and diltiazem ActionsTherapeuti_Nweiweic usesPharmacokineticsAdverse effects  õʾĸģ õƬ$mʯa(#4uih]BhR\c >=Eks 7V 57H? ίk%>) 2eoc9j> >n䟼WĚ|d75#;Ul̓ 5)'((((((((()ݩQEQEQEQEQE( ( ( ( ( ( |U%WP|U%WQ;(<Dž|L aլ ̶ :Ƀn7` gmZ M&HsY^\Ȱ?"7B?.<ŠmCHҵDӯNK6W1O(|`:mcGok /kw4?(-y^Ex]V.]i_KXera@R2rxs\xS0~ea<$uiA*814Px|WM#Fzm]^j1X~@KsӧQ}|3~ 'g$pwc潾 h#7ns2:ueTz.jZ}ƞ͗ha# C^Exı`eD,ݝp+ºŧ[.McIҮ)ⲆV% l$j [ :j:WE-w-+(dTYִk cR  u&qCpH *X|WV &ݱW Xf2q#JtvVS6ѱ_.!ϱPP˞e+It V;,L0#ڸ#8^T>M(l@" #^ExMgHNk8 <2Xאs cZxo~I 9!=n<,N`MwbEնoNlcW9.y1ל*/xtTu^X)q:HU^9=N@(|k[Hjןk2XaxڷՍ@xvs=4e݆rGSG-տ;xJp+ۨW~ZnyLL* Cy6VHN[<4Dݎ,pz{memG<B@5ZxÞ׮O^lu`o; ֫w5?}] &2wbwn;ӔP 4QE$Q+F9 nO4wQ%ӘC&ѐ1 q!Iz+m;#8>_:(((((((((ڛN@Q@Q@Q@Q@Q@ ((((((+֗VZ쭤CG%M8Z(/F& s>]\Frg8ܧP:Vu~ZZC[jQFUїj d2 GƇ]m?%hޟ_ξ`o5'=%i|m>toO/_/6i+K ?ƿi+@OO/Fu!\ǭV෎搇bc;4FtoO_)WǑQtxQiw_~w|ϵ÷{83@TO/Fu;(pnpi{@zy:StA{ѽ?|~x?L?~G?r.>_΍c' E7stvto_ξS?|z2.;U2B(7p3Ԛz}:u| gW\nc %|~|N(];|nc诗G\.cc7_1P4+_rkF& hq=>m:n:PWh|W۴4<d6 68u"`P{y@(]-ux̊BsA9'ӊ#]G/Z'MZF$>363GBw1v!e'zƊ(((((((((ڛN@Q@Q@Q@Q@Q@ ((((Z(J)h4QEQEQE (RR@ E.(((((((n-+Ty\/,MWv.kX$ D^\M3ՠڊ(+ƞ%^2ě`CĒc瓎t,zNJ e+##g367O=k|xUgOfs~Quj8yk hQxk:~kBBn2I?Sր5(((((((()ݩQEQEQEQEQE( ( ( ( ZJZ((J( ( QIJ(RJ( ( ( ( JZ()h ( ( ( tmc|EZr1#1G=zuJFԮZO\ zW;HN3>ڍ:!ۀ8c=:(nCg#M1Ls/w/<),h]f U݆ G/E_1hz5}*ȫ]JOs4_#%֤'F[{\kB0PqӒx"|?xoA,[GVcI'*((((((((()ݩQEQEQEQEQE( ( ( ( ( \Q@ IERRA4ERIZ &h((((((((*ZeΣ{(3$Oa{w&9u@s#9#]L-5dQkr ʃʋ "**+lfG(dۢ'k5šdN FD]:`p}EyIz?HTn p9k !7[E[m? :$m#ּwO{*i-%c*Ny)|129frO'@tQT]REҮu+lzWݓ8O N621v)7i ( ӸM)Ev)9 @4i4^#ou I #2{P|QjZgE6d3q t` 885m#]f}CO7s%V,gD5=+NPH- MJǀ?u !֡sJ!lJʭ#PI$cOWw#.{6YD9%8'/tuFjNa6?yakx:V62[gz(zd<}3k]-z(zooS<ӀKUGԵ W:\ܼz܁UTI'TzvW A.n \7Ho(|#8q>uMQmnEPlTx2OPQKI@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@;6ڀ ( ( ( ( (EP_Wlt=/MEjP1(瓂qLuqEjzutw_ Z&d!qV>*zX/tEߪ6ȱi yʮ{hxG񦇠i;FCg-%:\u=z2@X^7fOՊw$pA򚼧L=WM񍿉/gDf8#{Yĺ^XxKDեxLF18]%m2cR-xWWL-幔o'+䁀znǥz(|Mώ.5 ͭp%#rTkz ZJ(sE69O׭)3o@ ($+.QOY!J_@2Y$iH<Yq@gr9zݙaOV,zn1^X{IQӓ@t~׏m4Uw-\EqNT@ŏ;pncOq]N:;L{c5j>OP͖S( @̍~jk5 $Mǒǵ5OI4`kf)v5fvWԿ|#ŤtQL* NdJ.Z}Urێ0:@ռWvZ΁7R2 ?*|;]bSj|WxpNcӠ^bq7't@*2v''+)#CVHiK\98qҀ614JVf8AO ;c8W^'YdrFA#kᝳi&ֿv?.$'(zz+8--khv [jz-:%VKT P1q4.K|M0qñ[>k_`)pr2:'J\l/SdTr 3j4v ɿXz4듏bʀ>~n<7p֝{m˻#ݨw p`è=ۡX&>az}h@+z<J{}g=Q?I3<*3uܞ7 3PxR%?g<Y&=(y\f h."44a}hbx <hYaV!"6iB1NL=F ~}eon(T+x~GaMMM(噷H-nso H3q]quIln-1;PKTPdこҼZݱ]$zt 6=eK[ד]9Ғ#9ԧ IH-R-#./zѷz'5fm>+>(%ykfc#fBkҦL)V͒(,c!xMz++r>^?Vky!b@G5-,wD_ n=:{|{# YU&wAϛ^fg* `j#+Zs[Fz>n6x[B.h(U;ͮu ,E_u9$ѹPHT湛/jCn2:tY!(62t?( O2zGGJr7nhD=ubT#Ssbmn"!j\&p z3[~%dsU"Lp]h4ļIht,t>ǙxV=33u躴}BIGW{e8jqx1E|K{8hČzWGx3mְEhmJv8'Ѵrs^Ag=֟/mֽ/:i|hqIݵ4=k3W,i!{ .-$vZxCqjPg>㡠4_|J~AӐ:4 ү#J oz̶#sq:UܞAguYTt NE9A.:}+l}“QZJ)h((((((((((((vӻPEPEPEPEPEPh((+'PƇ^&xM0S r;W/SԢH016FzjuOv1^+6h1L*~xI]^"M+ C"xCIm'#R}jo7 ֺK[XlശGq9ڪ0+<!|32C1?i߾k/HIgl+ N鹔֣l>e;jq@z 'Nn(@eΣ+N+Ԑuy$zOPsO\Y̿;.TEtsKM|_wi6M]Ǎ#TFNwzWn2GX:Ow'{y| #F=+CKN$(zCm0~o-ּZ_BZל{Տ k*YUChK~6|xP(M@qJig+=( ph((E6SI@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@;6ڀ ( ( ( ( (EPEPEP~#~!k1A-ͯ&ؓP$9яz7V^ foqlfc(zs՛gJ~VZeLa+ eȚ2N'OX2Kh]9|yWqHoq?^@=^gTԷxTC=ƛ3q%Y#]̞[>X`]>k)XΊ#4x7NյXeuxp1+"5|UxM!6b[#rFN;zB4]Z=' =AK\J*H2AGzv~ms÷w:kyMgpdp#*oƅ\99oOz\z@]'SR7~Y9TI#uxC+)`z}+,u={Y:Jm#<_%kLu4m!?Jv x %Մ:B@>bw8Ҭ^ln!$)Z<' ?w5Gqڈ$pT@4{Ӧ*HI.Er֖u9 W_x;vi*M_Py§1RƸrog]Ҁ6cV^̗0#OLys!9N?Jcst6QzjXuyrĉ/&27qU|MwK;8'gȒ=9c5y9 oq|EB.[89e# 3׸(fP)khq+6:e}$r8#Ӂo^Դ Mϊu-ZСH ̜ p2dKIooLS̱9'E-;"1ǙiΪ88wuU/m-:O2%F` FAjQEQEQEQEQEQEQEQEwj(((((mQ@Q@Q@E=*\AȬ,=KEs]Dka7;ƮHE!YilvPZ kis0'MEQE-cj5ښ=?W/{޶E oxv6_77OdaO0B?}&?_uע^]jo.(04mH6iz˷9Z-;4%֭5oMy$3OJWz_tʆ?)@ͫX.ǹ@5+0.G~h|\@_n,.MŽ8O@hvE C+gvvO_ O͂jj]X:Q 9BzuW5EGmK(@Mi;,V{Xu++%v[3/@IxS#53ۣ*']3Gox{:tm֖ n$fC.{+t[Ϩ\EkꑘST sڸ[$Ѽ-FJ[imyqs.yP|??&> $UKS(Yzb+gUӣtdbo^EXC3v% }p:2q[l&Y{̅#,D^֮y*5_<4mzGklzJ8"Q.D5icعMx€oLYTU5H] J,>].䳺Qe;U@`Qwps|ҥS>QښH@N :LP IxIsl& 8s,T נB^w:emLz,jDz)tRK]F6 A \؜wuvkL1C-"$eIqR]Y@]Cq VdTzvhLs+8@s@/iި-7Ѥb-u8ᕈX|Iԡ@ԬӪ\_ΉǼ`סi|%kvg:$ѝ{8 k񮒄igs`J|A;"_L>l$!lס0t` pk/^Mc3?˙F@@>!>!xR̴ku$EL,~elzWV16^iNYLNT澀›-^nm^]{A|en4DsJYcYTV(_+fLr:S曎x:ϚD8v B;ג钵²s^c|.~h߁) ;3Q<]f5Ƞ D7Zk7Ȫf[)SuZ&EDV<1]Nsȯ+b:mo(׼-wpIbSK*+$̤{wNսӴ-:A 4620p@@*3OxI!5&.#ڟ#z{8xa5t5Ѷ4V]ȩU+-t & HvQmsc1wt? i]/{kk{f29;*灓zE66W2\[k2+oC#Ȩ/_kP^] _KXo f`Ur $9!H<ٵMUoê]iͲڢ+1+Ҳu_xN3[E!Z|=-/~%:smisLgrcrr8Zޓk)f{} $DߵTbFNF3ב@l|"tk}*]KP.>kʱ)l9>펹"W:'4 =F^'pTuc8兖hӴK(EUryzV|Z/kʏeNN$}AABqתjvl6YKit.9-ݸG<[uMB|mS~hjQezq^+Oz4v& :rZW9lsG]ti2i\HA(IЂ9P|Mk/X/αj0(;V 5i$%GOEteLp)L{p{UvXctӥ0VPs޺ ӷ 6cp3ހ=M+>\ZFApjMhs&M!P ڀ,<YS;<5tԘ^c_>[TH 7S "c9*Os~څm%y HGk#X|!u=MmB_,7Hz3Y]N]UK5$yNJy . ]?[:KVa>zJh'y4uhnw3,4m $ԌsKѴiz}$䥼A>jJZ(( /xOLma=ż\:na ϷCX5-K]i4նB"lĜs'Wа`2) x,lמ_٦>K˨-ab2)69¶qg{fZ>%.tn匑deJIPI.O _>kSsIV;W~l-Qr$m+@f`pUP?pf2#I&c~4e9!o݌u0edp̞a?w#qEnUB>F3÷"^qIVL&{+))񄗎?vI*ƭ#v XF{RX;߃Nc)+shuZT ظuE2vWlHslEZ-F8EA1@Z\q@&)jQjZeͤ)"`ɺ|Sx͉F1dץAV_hħlaX#>77SQ aZ0F z4CS`Hr0p[%lj xdimdC8NI y{NFq2T?al6{Iʐxn'/DS =@O"H6w=Ax#@kۋw5Ke#ɷLchFq%w*Kx-q3p?q DZȬ}m6 )&IJ"Jx,O@X-YbM@F2dqp:fs `Ca@Lc+;@𥾏d..u[u!;e11q-,o} A0$Bmm3Pnׄ-pqW|6<6kvo\mؠJ9&h撝I@((((((((ڛN@Q@Q@Q@Q@Q@ ('_?lҿ9Dk|`9+!ZV&MSX]RWQbBցJ*Tbw=dzV?1xEJbgtm@t=dpAɤkW|% .;![m`Q_ \'a^ 5^s"T4Vsy1zsˑ-l!_L@ $)$si^CΫڀ,4SQGpc:PyjHPI=(Эo ϴ:ibg] 1=Mo'w. -Ʊ< X"h0< '$d *2zy^D DU5`%i~QQ]5k 2#oڴk)o΀>3N PZγG*qV;PIK(((((((((ڛN@Q@Q@Q@Q@Q@ (i(KF(H<)[x1G"w6cQǥmъ?^xj,Ϩ Q1pW;T|#K~[_W2Ym:y~px`x5WI%o|1MF6xNkDhe^ RH=wHx&=B,΂Sj 90'j:4hIT>=OWFDZu9+{{cs[~iB}c@ f[|5`[e/8[P$FZ־({BVv01?Oz?)ȺSA쑘NOmKRxE`pF;Pj$y'tZW,ƍiu\wnkDTP`€9Zn7BYº4jx)(0}im-RR(Q@-%-!4\A@4|r{1Xq9B$뿴%k;B6k-}<XsOf'}p;svynX HfmtmH׃?ܵ})JqP`I- ٗp80i z+mf^qڀ%[ҧW2! `wa`# jQHFhѾ)m>zϞ:No)l&@c^4Ȝ"%iiu-4hhb QHhh PQEQEQEwj(((((mQ@Q@ E piEޔI@ QzQ֌PL\qL@ jYKqZ=4{(SFIC g Z sA\TҐqY߈tW-#!>HUd^G:oT2l@!Rx~'ƛ]ؠLwHcr (zfsVYk>Uy7th~nBs\/4ۍG:Ռn\[ ?L$rPHIOܪ^RuE: #'*x4>Vc}jV*qM)y`8?ʴtWNաy[ؑn,9*J޼SΗE_k/nJo YIr G'+}8xM'*Wiɾ}p>ag$r4촵\k1kXެf_Aa8':˨5X幼QīsЏ΀,Z&ëEIlGjҁ#?0^|ϱjV:% m)qn:c-LSx0ʌRO\Y-q!i#!&[mIN+ !` :`Gb1_+KMτ5 C شdtq8nBS#XeNXb70>e# c$mQ9rF{FO5h_5ڭfH7$HV}+Ǿ5o-f c7^ ʴy8 ;{EYD_m@,Dd`t~r S@Bg4+ ޭ{m*mr{}LDc. F*,7]4+7],59쯢Y<=G<B3ZpvSJD7P0sF36л(U; rPN˴cQ{`eV]5-~5і1PTv_Ӿ1I]?+]Lѹwa~8*E2.7hM{LPDA鹀~վ5J4+ Ҷx` T9#+ -cPx59zNw@Ph((ڛN@Q@Q@Q@Q@Q@ (((((LIZZ>ռ-JYͪKqH9RGU \ [` gv-7h@j|CoHf!?9@3\5Sa9 ljOvk>3QÔ9[".3(z˽K?66f>[Z]D;?JDzA}}N{  Y_MԮnq@4SBI6_0 YfZ]&8V Z|5 rY_mv1s኿w-kF"\ KW9mz %vpzŀU~htqzRL?J@zE(d$FyjEf<€*n`Y󎵹'2y]\L 30My5vA!kм?i$4FҼ1CPal9q@Gl` HL`Gkc7JA@Ҋ(((ڛN@Q@Q@Q@Q@Q@ ((((i)i(((PEQKI@Q@axb"zTl !H lhcQ}<% a>ϖЀk Jjۯ [&heI,h rEvP,]>$ҵKF:tyqe @m.:G’[}\o.o`㹷Kr 14_ۏZ ZL [O9gErIDg?WT!9ceA`qU}j#^C]X퐨Q"8 x9axFTխ5kF[˝,Y-Dno*U\r+stojg357_.N3ǸE^h*F?*JwژAJ 迕 h ck>ҴA*4ȧph4MJ ym#S\y>ּ!|=?`֣;X+Y|>$WSȲP' 0+FZ_h_XkiLAa 3{r0AU5=[OѭRF$'+;[T!IN,cQuG$`r>Y/^YxwPu[;]f]?\MOo#lq@Eq|BZqQ {gp#+Vi+*y.mqlO(PT?ݠ@(k}O/lotZi/._<A)h()h+ڥ=~`%yc#$\dW߃gW_ϒfAF9 4G`Wup%6G=]0>!K@)Q@K2(:S3N"Q!x)F1HyPbZC@(h4QEQESSiݨ(((((Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@d[cG5߈۫]!s qzկEq:Cw jE3[6[r>ruв5-b\u XP*zEy5_ $xZ2Gum~]m)){֗-S^.5$7T*['=WEJS،Y'`$;KfT5 J:}]x&AIh-5;([!PQ^UbeF|sr qo /AR&b!yqJ]<7FV^0𶋡62/u FIhJ|Ak'UTђz3;C[9 mo/ghoi#38_M}=W1պMlY~!zڣb[v5KIK@%-!JjJ) fvh%--%PEPGz(@(((((QE4Ҋ+ɛH_AI.$QE$TqCSG{[Ts0VT6k˼wKxZt0A ,( ~=S\Ne&3rcw6ր:ۛ,x1W =S;c HP"0*FAuWm_UΆXAon [ei##L685ϧE  5_o]:ƪWylgi=ho Ӭ./i|N'zTZ^gij:|u963:wxzwZ^3Cnl\_EG,;I@WhO55T^;oiwmvQ1!Y0IۊzϿ.R Ci 8w犫G i`u]T@J¼()«bXa{Pf1@ EP(1@q?|izBR9?w>._]i 5Y&xeo.="2=A#+>yK2IqI#8I$Ьu+8,nbe%+V+O |:^Ρp FĀo8->1j\N+koK3w zOѓ@<3c\K‡{{t2Ŏ@ gߊ|UKNǹG-{NOxŖ~(,ʥKkBޔ8/4P)40< \Rnio^W1 n^_%iU-Q1u@^ZgVmMnE}xZ2jOV`$gW)[_ }.hnk,۲Rrv'8+>)Q?=2Yfmܫ2(푵TwIePZ1'ƿ,7FH>׳WC`>7 w;?ac3@Q@ EPEQEQEQEQE!PheXg N'\wi(F[sOϵv/~iV71G –RIKI@iE%(⛞i{RwS, Il'2GkvqLWn(M pPQA ( ))h-QEQEQEQEQE6iɯ=׾!ˣjYN2ƽ oxH>1#,@ _pQ7Yf<~*I1@KdR;YA\L_/")m;O>K zH5ɩVmucǺr:L&-\ic/!T';+oj Wo#]Cƞ,kw]ȭgҴ{_2)E_J|]%޿ #qa@BAY-d B.˞ `4,ѯ<֭DnZՂA*6 =vbE'КcoON}zz;0o)b=sw:`(:kDe5m[M&fiUBFPot@(ȠOMV Pglh8?:c"1\ezw(5b/E-00.SI(!R (I()E%:((((()Mz7Ҽƫ}+rvuʀ9ڍZ{{R㩧JcץB->rh8qEC~QJym(IOn*)b[hHdh.GΛ3ڮa|mWYV\r3[[ȕ H`~PA=@ |[j֚u)gst?/NA\W(YLט"CңK =h|Ke;ڌZ龾tw5^x㓞shO7U85tv²цCR8;<0OZ&)q@'zu7:(((((UU= |㬟} ᾕ>8uNGT84E9*Eu  `NSzjU p z GO6F{tR'Y6ܣ8 L,d4_5HPDbyWe[4Z.RIkG;/#m2pG?Mp]4K&exPA.Np8;dMgg"ۙ#726}3ߠϰWMSP3 5b4‚z G54C2@ʲrDfFL`*xF3#y~HWU]X\iVieN3'?ֹ/rAmi{lXmױ0OQW==iXF8ă#8~tقrM1o8ϭSqAV4km,y'Ҁ0d",p3Ҭ[ nߠm0]$VkhKJ- Uhww-~!i%BH8ӷo# bu|,.9Mek}t W_ozSBauݏѓJ7pF9,h<] RCpIB4'Pu0]`&KC+Es{¾r6@n⾐ݫh)sMNQހEPEPEPEPEP ((FW?⫹{]J1o\48*q5`3QsSyP1@nzTdPri ?.MK)&?7 =%ՄG@z zcjT'PaWUP1¥A1@w X ,֠M@,Uqsz--?J4bϹϖtƷ,n\=iM: u?H/-y+1Ǯrs?fx[çV֯x$dHL'i.۷N}{WkIu-^ѤH%_g:"|ɞk#^X@-{Yj6Mq,,]0?)\(9#ӧz;x)|fx'GFRE1Oʱ08b 8뎢˝R VK9 Bu0C"䌩:1ĺmd0_j"^(~7nA|#W@!10 ǥywO"vRJc~z㷦ys~%QRMQR+ȼ}n&*(b@\`>0x8J2Ǟ|:{=x vP)PBbP$SHHȠ4Ԇj#RD€#&cR5Dب؊V P=Wc- [#"95$~ 9ɬQwU~ j oH(e뚝x-LA$fOyZmY ʻu9,mn'+{XaJv'sެZǣj3.mYl-L4b2b^ Jvɫ =FjN*t o("ݵĊaЂ9V6fgQKbCz`c?ь5X ހ9#Me<Z],Đ}^~OFy:t YnU 9'~5x돥X$4i^&1J԰Λe#259q`xJl)4b SҡQV(>8*A?\1~8u>ޠrO&9׷_c"HQLQR|aD#1My׽{]oHxe Zn)6EBED¬Q2-Q5NPDE1HzZ eX|zՆZ+ V8v<ae9`EYNq@9Uf @sXjR[#ַ [ƶQ:/?GQY_8;md8V__$(Z$hL3".`@-O\]UCƪ0-4^F*gbw q"m!ܕ*WҀ&pS'ς:mp_C(]#R(OPKIK@製:(((((QHiE7x'Mp{-SP;"שn,چ -RЁư?칌Cm<dQ$Kqd9Ҁ8mF'y0;O;I-X#?<{d=k_1SY b>G9\nSj0i$ u$qٰWk;6Ӝ-"Oir*{4iJ's@*䶱^*C< Hs8{P{%P[44@zauMo"}Skn<1sa Mp _]<;]Ou-4A aT;0 ltsSfcZ YQC1އ jVJ7c@ECnN@*KS1*LP54g5&*X~:ȍgaRץؖk rI1rGOטsl&E?\Pnc߀Fq8 ֥QQLxc{(ŏ㼐(Uj@(bEJE0LEy*i60!o>dpyv Ϯ8lب^y^ՅJ5z]'a?E|gϸl+Z$&ฉwkRS![I6d`$ghY~Z3Rˆ(Z:Ug8d`j9+8"$yg5ssmhg8}XicRU5d xXyd; $K4yQ`J0z 4* #Io,)+*ʸ`A**ǹ4wȲDX,8'L+9TrIs(+ EٽBɥ.$%H ր2-4s .ҽq|i9<5SZɌpI9cPZ?΀:5-%8}ozZ(u( ( ( ( (iESIF|K3H88ҼV/w99USqw`㲚,RBcڀ&jh(9bUA+14r& )R-Vb3ޡ֬E>F U6oXiR5I,yTq-v\y-\c;fA!lױ?qmCڿoPGmnRap>UO/Taěg(6od0 rq S^]M2=QIDK6H   0H ^J2sPzڀ& R(Pzh>8Qvg)SH+9E :,mMq,qD,0UQMJ5@M⻍SӌэB9% ) v(bBz}>"爼;zSjk,FX@T7*OI0zԡA#1H9/B\,21v퉁*vקlO'|#ww)s(BcȔ2H>+7[m]*Q}. dp$։H|-Ю?(+zz%LY11#qzWHTq<(q+W+S*-V]N%Rlp~_y:玟^=/CnM{$ Iˑ=8 :gv] h(9*)vYc )|_Lol6`E8*Qi5 lX?7cMQQp{U/klGGr}x{Ud⑏Zwր(B>sNE WqM0G@MY dUeasҌʢD\'U(&6~Gjl.XMLb0`cx w:İiTkNO-@qЌKM.͑Lyf$`6AARGz(@(((((Jk )v(+Ko\h>PM{4B;ׁ?m\9O;P$sQU OaQiZNs0 }Abvʞd?pC]!uO%z'_ѩxa62L&CeUղy9pASf"YMj[G @RS'nAl@Z|_gwj6 p#m*7\PzwⱵZ^+4愻m.17|LJ^-B61"XQӓY&ڵ4PۉS| 9޲E{oTM+paw20 <sެ˧x=NZ+K;]xllqPc:}gKQA9T''&?kVz]nde6[TqAƲt—vWZhiVRzgս7:vG3N|Ԟ?:ʽh,J "dL≑vb1ߊ҃]bMx}.g jߐ,c'&R`~|w_q^nbxW^nZE=XZmio¢L,3N]@# V]y/IbV^8ft}Ea-y@#Ӧճyr91uD.'"d1$޼=7> H` J;Xdd@n1ϷZ5j>(YwL6prY@V I)0p3wTKuA\qWV>f.rjEe"aⅎqn9;PAxW߈׉з0&Pv$\#SnnLVUڔWèBh̍jV4c P}#NWvfuebaRYXA$jڷ$+xR(XE tzW|@qj6t> pG|県q^!sD 6kwOդ[id`qnH,$zPO=kYܺyt3 d/@q y_w,2?&YNtP{ʱѯeqr*.['#8=+՜rHd$NOnHm3) 9^v7겤ʎtR'<ss\o?RL1B#;#=+y5y;@@r}p}-j7G>݇B;ip(9n \qr#zex&Da=6u7orNeAvU7`=JE}IcW> ;bp~>yNI# YU|1jȤc OFbDbdbHZw㷐EFw LzYLh_ ²oYt唉]#] jBv:}{]nj@H}|7-dG <6}}$k{7￾O0_۟)8/h`5'l.blfhAb3Q@ڜx"LU.V}k{ʜzTs/Xc @r6jq96{#Hʓ55!$\H0W5F y.thnHFqr8qX5ޘ~=VRpt948+Y,Jd#o@lpUH'O zGTkXpx%$}MtIwrƥLPvZ<6ب rkK .3P1@phȩf NCWnɳ;2Pjmh/@5 a`(xH81ۯ~N9k~gTxb`'!Wҭ 2lRēۊ+;࿷G߃+)O=pHq6? RKj-E fPH1zt_ h>{t3gSKhu5G("\0dtzs\.sdFA]7֩p=K XU_Ps^G-yF0c׿z @R F ==fQ-nYCj$Fq@C+2Du#u 8 T[R#(U;BJ 7Ӵ-vz==p?*u-4 Fvº;ʵo8Tu۳{A@࿇H0NfS޳e75KMk4xŊL%껰UZNHET'`r7㟔栒 S@B(MPViq@x"㸑f@nUƵK[4DLm\#O~diުCYB9P#;iXΑ1$2Hӷ|!{s+w:F&X `OmkaP[\MpC2Ɏ9[c-,* ˊM"x?x,P &5@,/\Rٰ{hcWM hWX8.5~.$"f( sjWcV(x=9={5i`{TE=^L/bf@ 1~c V3H 8?85vw^zS{kER?wP*M3>A#9pCN1u3x)?*sv0mBhvt ڍ̚ܖrWPj"auX!S9 45>84,@8t}h bK<xW}?- -ip>?G]"Ti.u)WzVZ} KCf5h0)ǜPiɯ0Ϥl{p1us@ݧJjѿw)ݥBr j~Y?:/CЍhw4)S%(KIހEPEPEPEPEP(P{ou5k_A@*@56^3ARt؃ `g viAyE`d@094~_^kvPk+<3NЍJ֦^#A]SRK^@GXr'Z5 K]M>O:;5BH9 [ʇV 9اUа]xV3kVVvA'76A玞`摰kμ#E4IⲰ# @@F\Ktn>{ cymQ~4pJ)g/R|yu$+n, G My`d6;c>f ~jįpD(O\G(WHI$NېWͫۻ> B pԞ+ Kr_'`PF OBڨ|9I|H鸰dH€>繏#KvmIC CUeѕo*ËCȆ܊IV;ɔVjb\h YA$Ͼ0=1LJ[A'ҮF,6Sӊ'Qc6'p:W i*W0J\ssNNLޠHrhƟy4hi-{cypA$݌#Ei/.KEu%ER{ 1i:[5%OfB$dpNpy4Z:|Gw.@=:ƀ6 )s^"hpA;;ϰW'q{T#-(p:P]PW"9?eu<S8}}>?5T7A|5e e@Nҗnz8*Lq*+>9 ݃ 0jRR*m22GJnT1Q+L)9PkqQIG# AWAlq@ODH#¥&AZo#o Ivv>$0TZ-Fa<ZyeI]68f nOx}uRd8jlpFWUhE4@ga+VPcr|+k9GmQ@L2;y$}=lǢ;$B sϵsy;]w̑!Vkzf/sڀ4\߽$)j@ZU`(a7R?R))u0Alu_9[m~.ql׈j)V@G *d:I+܇ x5/kd\Agid~QuZmoy5dy[P@'c5i~SOOvN4WRz]J鑃?5lAPZ)GJJ((h((((JJZJgX S\γ}f rMD M(i zqNѷh۞b(!8Jy8,  ⼥Q@g#<}WT`AL\@ĝu5)≢f_}V]ewu^3}8P0k;)2HXOӭ,mPq49Oi7zgc<@iR#[ԉkoapk)6]09ל\ǀ%i$ ?trFR=+-쭭^g S#zOր9뚮uIyImxZUl|ߧZDGJXt丸kKmI rI8IFN4+qs(_s (J)(-(@((((())i@ k񾂺Skֿ2u=i3B!8*hKAh(4B/N"XjvY^GA( AP._~f$^ WDk^ȷ[͛~^cm6dH>'4=pYwEmVwF2V$zc5ݚ =jk d|m'Gۍ\߭d\ǦУ1|s}Ψisnh! 6tN'F9r{h~!tF3"q'vo@}FAT~'D)2ۮؖ900? zW[Ӣc%aanYXyd wx#a{!#.;RRH#4Rӂ捼) )P98&Mbjإ01wҲ+"<>is؁bqk{",F)=1ր6a4 0)Lb| UaiKl̕~U[jω`u)&QޭiֲF# }@Ԗ~騡TƸȸ@f}owpasnhSn)4i< ,]A9$PNGF:nĕ6 !z7=hݞ+%>V֖T5q @ |X 74k$R!GF xi|-Kcp^S!ٜ1JβFuB X\_t95 :$/#cdj,.sO$\ uL9[9u tF$I`z3~;,<OIޖ ;GzuQ@Q@Q@Q@Q@ M"OEszKoMs}POz5r^h4&{ TN>\ּ^.״?GrDv!`e`~f:^@ɭ/x?^Wn$B#Pr6.F#a9^ǚN|,&.(* KV_Voj%uR21Ǯy(GqgkYi{s0ȹ\].v@`VFsI5䁚<6Gxec+H $ٞ=jXgj:jKp@S"`:gi8'rݩVMBL4HN3\g2:Ss@ ԊAUPI x#fjo5emrm U l sֲ5.ap< 91jURh R+m bp#p moSфQ -N4[ؕ]@*qZa,9@qJR>8J܊\C7$^5cq8g"VOpFA 3oAZz~6";<{U;i'ր9]@QBSkf9zǺ\~\m}wa-dO9cNiဥLcrJn8ȿgҹ-Ux}3uKKE4-.H)A~֮K ::,KjdMűB~N8kI9@ ax{g%}>=pbY]~kI5׏,J#eU9##Ճ=dž/t84*] Fpsy$ {=t8uJ[7E,WVN_V _ tW7C.^DŽnx -k\ުQmKb$iqhjx P4t4}vv rЩ~{Xj3[E6ނU x<Mώ5;kK7GdC#m* Rr[X/0$8mu!J ۣ1NH:JKK;{vC J=p9:jU'м@0C)p1E6ҘTԠR#Qni\R9BXkAXjV:~\76x984 i!z6l7Q$qڸ_*I|=ca6xWr"`o4_>%}[k͕)"-?nc'v0Qu{ૅ/&_[ԑ'zUe٤cp݈?F(PGP"5o j6yIzg'{<[+bC*F*W 8<0`l+u X~ aif?f 5[ic^6 EcxBA|~oC_Dq[}nOi'[QKAt$}Pfŷu{B~Ei"Rn:}23|y.B$- tq^=+-/İnhGWh8+`Gg4恔$n_Pg2Yp2p }kWI4f>y dLmA4W-n\|]΃ x_:b]ĂٮE21rOҀ.Oy )i(wQEQEQEQEQEN֠5k?WN՚5o vrS{@ NQ0)FZ(a@ ;gz"-@M,۱|m6F\P#4b:Rc֑zԇP 8 xd2o}s[\ rt-*y *0 ھcYPbDqUj  k2]ϣGi1;_'Ǻu\ Dk@XǩcJ_8ޛyyk6-r\p'PFN+_ZtZwS{X $׌P,;489+Wbg㗍1dPqےp qt:?I-̬ne0? 0g b8!@ι?M@7 G ׯ9qڻ)nstTXd e 98ꭗ-mJKo ݾ$Y3$O@;9%^ZJiSyƬIQߓzk.6˧C3Bwh@s뻮S%>c.jg -Xu1]`.%8#IǙ" ==jP0(,T-Δm>dPI(@QOoHm@Ey*>zJ08w; ֖hi0A F$>WacN>g>'š\Z_/ HQGӥtt󯌆3A/|׼}mhtjjWG$zx 99#\axWUVk/f>1S e բGJoCNzҎ) 8@ijzFa:;N)`<ȋecG']֥Zj|zn+G ῄ)SIPѸpWelv!=c^ՙcc )$P}+CR4պ{_ߠuqr =zW:&i+Yl`16y}Xn4tO./U$=h̼8xT0˦L./m;Q@< 8/ikNdypH*@N=zՇ6dQHa Y1  rHYq"ؾޟ\6[XF׉k#")GH}{}0_;H㲂T \tWv_+ylf6(UonԺ4bhBY] wS@uj-_!. A|` v=b밟tjr8V{f Kn4K%K{)8Ťm9lztWorK(MͼN$~t ~?P5A?)Urܚ<b vt&f"xSwj_x侳lkdE^+i[y*sI.}I4$a5+aItt:Q@x(wQEQEQEQEQEB)i:PoZ_ s}(L5 JNGڐ~,NeFޔ}iO xَz_`P!M~[4 F?(WZ fy P柌HiFEG#P:h 3P:{ %YE,Nۭīײ̶L\_#2=1 PW.[GS!j3 :ⓑ>ׂ m -̇}ܼp$S?L֮in[»U~Ԟ5O5_^Sէ1TUyUOwyMRq #Ա;_"Zu/IHmݕ}$I Ǿ9ַ˅ZC {? ԼC!cX1 gZǥĚƱr^HObcŨ֝-6-(ap19Ҽ߆|B&Q쬊:y9ڸ=rAϰ>:zsa68%X` t%o) bId;PNiǎ)0٠O> @5MJ]H\T#'vIFrH{PX >1'α~FS@Wf,4'i,G&3}KϦ^Gr6g<=xDMſĺ/AEև6A㸾ܫܠn0y;vk_-;-zqf{L ny^мUkeXxM"}rսbѤ{hԴ8fE{R O8y; Wn0jR#M2Sv84T^0(F`H`x,y" 3cַLÎbj0t_=lDn`Ty<={՟-=77 9 axb")q@+h84-&p捙~(bYk:U=JPC:zs\ī?wk'~V8aWgox+LԗKk=ϐ0H=N;) pX`)9ۗj)cKF2y~^Mh>7]ahKe;A?<ѾHFӽ?^{pձ׵7zwuk, ]䓓va~$2Nז{ZFyq@wm#z(e^{!GJ?Lz'|cZE' zR:t<Zz)k2]5EprCa3@6åbWV*Xȗ'>pxvljBCLi& l؏)qU~bO뺝 \C3M*z'͊?=VxZ]y ݹpzb{smW]@ۢD>3] ݌Wcdqր4J)GJ1@Q@製:(((((M:h s7${ 5k'-2]R2Hyjsh=K|3ø=~`Ӯ%ZxN7':!}#uWӴ]2;8 xT$qQS[Zkm0ƑDE(: T5^A.;Dvїv$ ܑS3]J…@I5gď:ԶGG٭Ƀߢܐ >`NL60-mAkQ Ix]Oc:d(!ӼjF㜩$`|:֓y\h&]0-F?Rkin3zO34bjz:Vspn Ya׳PiwnB{=k.z}u[^,i`%IO7 /34G͂A?tJ G) 0(0nqu积>//tD-,k{*a'kC閚>^U@MűIԚ(x/*M#qJ8\P*1. T2~aAzR7([kZEōچes6vk,b)|մy[Ԁ9z9ZK[=kYYu$r ҫY|;Pw{fW݌qfTLHIaiӼ+/IXq{ct׳ifY$2r@{V4}P7+ji ,PrO~ۨ=n<MiZ 5bXR $ֺEЎ)sbOï, 61d欽#ᭆei%M۳N0 unԓ@ ¢ϦI{㢻n6b0P~$uYiYG@#LGAɩzPP.{Aq޺%3Q/88.ה~?:t2NЍ_-&9cJ( ;GzuQ@Q@Q@Q@Q@ }05#-C s:1l€2P#PHF)1FH@i3O<ю(sK)Rg"csЍ?z6)p=dgPVi$uHfcu$/*9sڠVbN?u%G9n5o$L3mIչ׿եv[đCH@UP0iipCGj+T3O/4$qF(I*^Ư|WFhuTrX>߀P@9nƑK"hw8Sюا_îV&lH28<6??R=3Y>T(D1iPI>܊a෍"5 0e=hSssH 㚌q@Qu(2{zAWZ徜sL1l+*ܞ t[0$!c87c5hWs}&5ohF,Mk48A9u?FwRcect*M6YsCFo^Ǫ Y:bA$sҀ=Ut8\W-^_xZ hYmcicp6cnqė-ۊ9Ow2.@`J OV:Zc1`0dV|9{K+扥k;k,̣$Tw:oqs 3I-dTN0H JAᒠxt$kesH.(B AO 5(v4RZC@ B ڀiI sQ +Dei|~@ ]i6G Ts@P;)/HsbxDm/^)I4ugiE5F4@=jLqMK''[|P g4t0iDHm{r)di_4Ex4QEw( ( ( ( (ii 8u>ckָo ێ1G#&dSdL9S@*81iI@i9)n;Tqj:d/oY۲O(x[Hݮu[1Y@8 rOW GO?Am',|J]3i䓓q&|{v]WQ-ȣO>^v8&!k(!C$1U$`+o8ψ z}3gqߏ~6x6.TkH7?$W7ڮsK0|z5{/A]F X^fsJ-!|)24^h#4dcґw @*:֍-N[7XP7gʃk<׏,12DX.@0״ˡ }E۽;@ y nzW_quyir!E[m cjxϪd] +F@r8cTxkw54e! `1pvgV)Cjw$B`g?OzOއ:{_]Dk3J@BK!`O'`u|+6M^]d`ҳu _ϣ;IĖik 9`sf:oSoA~6Mosg e| Nx~ ]LěT.2fӧsLvu/O C+=ϙ2~|n*x{V}WZ;gr_'-u3o tB|t&ĺ֣xEKeAsݵX.FH:تgWijm`2&mB' t:޷#"H*H!Fބ4jĒzN0 ӌ㌟ q~)KٞkU E"pXcjmBTΧ'mgSrhō6<9"f5S-N- ?VTX^MUg޴#ӌ 5ᨤMѼrg8)2=`PA; f2h\Ɗ`Lwf426wbI9c4 .[0JFI)4}ߛ4/\O Ҝ(IZI29cxv [l v0ږp?-a)z(1֤8;`4ya},dR.iRzPi6NGZ0{P PwdU!AA3L? F[p}6Kѵa7oݗcn?qک/okgq[%B[= I֜vU7ī8>1okoZbHl`|OX]F-&Ln6@<1svA|K^akp\I4Xb"}8%^ݏ>Sş5d!*1@Ԏ)q@E4j]Tds@ qU/ m'LA0.$ '{@ 䯔xƶ6d'!pR.x!@:O-đ\WWUb1R-p8>5蘦GġW<RWQK5 !ªz{ Ğ!g/s}>y]-^-egV`T |N9FPiAPFq~Eϵ{ä6}"oAv{z}] í4)L+}xzvc8#4Ѽn'FzRM۸4b0z?E?)C{i$v+sr3+ H[ @yxFKM`f};p2k3#=R|OF*\5nF3ju[?f!y*qc$<s^}{gSh~ Go䑏sX@riȚ2:E> ~54(OX>e@5fɄ dUPO`zg^ֵ/M-#ZWi&S $X䞜݌v].z:c4@HFi @ B:Ӆ' !P*Jc h@&TS@ P(ۊxR{\q@  I! PGJ7-(R`z)RiT.h Һ/<# qINM(QހEPEPEPEPEPSZSck+ M">0()hxDN' Dy$Q!wf8I=*‹ozm$5T>€.)M'zZAN:9,!&ZƲ\[CL0ׇ|#kL΢cU]ImǦ88g>s^uM7w!!n-neRIrQ' OjF)9-j+yE\87+kO Oh6`t7V?w?X>~*wk`oL@qp)0SXG$`>zSO H޿Cbs?o4lHǷc< \'X?.88'R,4\]=l{ž7O!Lt_h&OҐ0hs4z~4ӄ'4F`Zx.hzڹiO22۴]wt|g@ 硡ԯNkC";Tr0:p9IyĴ|DpT3' $RGJŲB]̿\gI~xx{Y7,!8{dpy  Gݘ7Q hG?F5QwufX#mJ9`)N4E&3Ҁ 0iBjP-F)qM#wjU>ӦRZNGcGVAq@ iJR) 7<ӁQ@ ҎPh /3?E?\P~Eh (RI@ 6Пe)>xIJE{a,c/٭۬Q"#Ҁ#6cʏ _*?Q[1G|P(*H@~H"($Iڪ(hS󪟨;(a>1NRrhM,у@ I)4M \RHs@-)p(f.xf.\pR$PJm졲xzq~cּ?juq@OTÀx`sڀ'0 jly!n3|Q f\̟fd4V6Vٲw4 :q8 ^QNh#xifPx/D'd # QsXH@ҫ"ꥎjtfP,^q\ӗJC py]yr)vBh1ybuRr{stc"DKpqG!N)YH6b{)[h4c5ih+[H[~UXB"PҁGA@ ((((((ъ)h1GJZc 0}i\PJ-.8Q9O w4YW;d,zPJ(1KZ(Z\hfE-f(挊e2)P4PfZ)(PIE8 %S@-m}\a}0ƱW}-hkOAKtIF ZtRiIF Zz <`у@ EZtR`у@ GN) `y4sF )^:`у@qvgȣ6cIF 8ҖNh4 (R(wQEQEQEQEQE( IJ(EC@h%%?4fEpMg/&ey@ \ߏ|M/|xH g$WI\OE]nլu Ϲƀm}4s>XsA [ KHo<`7p=ǿx3MǍk^,K* v^0iuǂ/SY;xmg xCu5ʹ:bCss$~f(]<< Gn6z,7yS|{$9F+BkaDE~,ǒ1 1sP+=xy%m7*T0I|v[>+> {{ZwW唆rLe? AMI.ͼ:mfʳY[o $\ԃ&+xxkç—+>>ym"ys^y/qN&7cIe~eAQtW:M|(&EYD UL͜7sPj74ڵl.~,\ 80s|o놞xXʮOc#OxI_xI,g42IA8`A+=#_\c="Wzi.j؇vp!1r1^-7CCY~H߾?t-e|zFu5 $QFTޤm;W%Kqk7>nZZ+؞N<9OjOKZ_I.0ۀm°=xVP> NuFX+h҉Rp!83'C5|>ӾX|(W'H<枼c?L_|eVBpP ':tO[[܏&Dđ~鞕< Olwէ,Hݷ2x*g_ ٵ+_홧 n(Wq'wA `j:cnƷ^ $V᎛]sT8{_|6$PbA#kxk?<]i=q y<.D,89k񕅆_3ZеԱ Q)r?u1ѽ=[NI Linn$v9<䴈1==xvzު'd2v) 5k:45M.S˻ T֍ƽZDt>ЊJ&Fq@o—~׭ӭ 7nMON*Z#CPn71 gۅ`{\a}赯3~%^_Ax-~?.'&E%%;4ShQMIIE.isMFE6vE@ \qE:ii PIK@製:(((((EbEJ(Q@Q@h뻮ɿ4YQ7V[Eȥ^92=A*J:nIjZZ'hNE̻ 8ʀq8 ռG42)WE PA4/-tj gt8|5teRBnȟwg3Ƞ ;>LvH5p*{DY]O݆[ɺ`,sֳCYݴ[Y7v*@ !2N^1K}kZU2Fr+[vG$@h`?7?#c~cv8\U6-EDu+ X` HaYxú', 0idΪ ׂgX 񖛯te` UF$_LzGqo ݼ04)WE PA? xm^;]#zgV񏆣bۺ| GmTqO¾o':|,O=ƕ]{sak5ggFGYZ|1}j`LFA(F:z}wHJ]Q[ӟݵ8u Wvvkym ͼ,xb6H iO)+&K3m<0ƀ;t:}F-F[ Y/]ܼ*eA9==M^a=v6]6!Ql eIkiĺ&cI}%;OWh: ^m*mN=94Z/f\ـL:61dAW4֒bePm0(^~[K]Jjl9#׆%<뚬vΥy$ 8냎5t??_%|cߌuvmb^QIԫ'w$c?^_Ax?D-kߌR?!"N`E&ih((((((PIKI@ EQEQފ;((((mQ@Q@Q@Q@ E-|P3ƛ\'h뼠):g-KF]R[XY81F N$$|VNiiXGw oO ?:=RGX~ЈeTZD'C3Myg~5i0Z]B*&Y+*" OS^kRKk a$p-,8ϩw=h׺EDbG&LӖ'wOC@%G_4n&$#O,k<``*oXn}D6F;rF0+σ<>_ 9N"|s֦uM~{Tʂr/@CᅰU[ 9IV$`n1\r4x^Uҭl)d>c„ {z^ϯ/5&u /7nAHx8?^m] Ϡ@\c{|'ys{=z_6˛7KId0Ys`VM*KmTN+]fG(,Qr{ӵ-oLbf|ϳ8rl uo uK1g%);vI f]u |$ZDHuf%z1Gc\꿴ݦ役e$ҋxvS s^aimV`rzy'\ºuZ{\]ܦ J~@BcZt[8_:NaK]=7ۀ# 1Nބ4#mė&0y0tRG=rz?Mh>LH]OA)? %kbZq 3I:u3nO6z w~M/,]x0kh Ƌ[a5!y8A`uw!1q^|> tey+K;g5_e]wrΎFF*:^>*ma.no[.C dé&O=_lKš1$?xy!>].-\ج$GtF"# BI8'PEPEPEP̟^2xAb>ǭxo)WW%_h"lG6~\Q@Q@Q@Q@Q@(((((wQEQEQEQEQE( ( ( ( (8?&ey\h뼠+~6|YA"GF= {&'e/ :zw~FyIRSH-;Nr2_i kocJֶv[7< rqъkxc÷RM dX/;?kIWqT^YM_jjqxq'Dc`N?H7zdQ4,A'8(+J:ſ aUH/7Ҫ$|*O5D<+2pF~lPxĚjW^ӭ7S r7 }Էb1nq]'g姕KɎzQ_3x{8]R/m:)ddHzGsi}E4IE—n]63G3Q^Sn[mK:v^[sE'>sk'eo xIn< Q*2K4<rg[Z;V$.@@x:$Gp$*x'Wë/ϤE3yd09;Yi3kz6-3Zlʐ,Ar}5Exa5ƫ+OWD\]56[]'A錱<%/MGį ǠImܸYR/rbx ; @C^ Byꖶ_J;Io9A@J5[.{rt 8fV |8$4 Ժݴ7B[ݾ@P)#|}_kjJHgɈH_jI*Os@Ao^kW046KG7T7iE,P\ڒpNpHꦼ/QmsM𧌴I"%)nu[i#eo> S,$DT-dԛLnƜe)6ѐ '8+g}Ex]oN/ehZ?}n2 ?uڸp1Oh((3J0ǁ4> JR?w{$BD(((((((((Q@))hwQEQEQEQEQE( ( ( ( (8?&ey\?i뽠W㵜Z{nʜ~kڨ:[0=xXNamrGnrN0 TMk@׈<;Q?[TyP)ѭ<=iWw: }~<mp@{I?{izƫ(+GgiW"{v T>V[[iBxQ-\Y,*g9જW@j-<)I\>1eLN9x׌m89wM#gqN|9}c񮎊|1 > avn;F:Ϧl7vSbװ;G 8#'=u԰&5rYZ"RsijH=LV|)Ogq@Ys^ }wM ~2 n뺴?\WZ0Pӥ܈ e2URpr>Er_#$uj^N+.͌;:'5+KV:׎+hK Fn<'.1c;Uo|>}KıxC֥5&8D2 #j(ϦosZoe?%Uul,!JA>_[xSH4:}֜f22h-9EpZ?ëOE{uE/J?h?Y@Ex4M r`)?m[@I/hoS-[@Ex4- `)е/"=/hx?YK  3`((P͛0sңU8f_ E{}cG"ۿ$P^&hP?])E[dž??+L޻g;,h2i]hqEd`1 }=PQ^U ¿_rֿ_r=Zh ;Z?<+@kE(ը*__/9K ¿ߘz߅صa/9K Ÿ߸zGA#?Y8!TF5)nN# `Gh~4 . O4JSψZϹq @_W[OPN$[()23@-%QLEPEPEPEPEPEPEPKJ((wQEQEQEQEQE( ( ( ( ( YmnbI I) ~x_6M%lcM,cV;?]w4P {ɹCsD?9?]?Nx ?9?]œr.S~NOuEp@瀿uQ@7) &O_7?]HtX#7RLg$a|ӌRi.F 00גzq]]|=4$+Kpz|G=:TQ xGD""4:+g${{gTQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@製:(((((EQEV~{hzfu;1 FO@;օfTv?85PѾ}j_ZOY ^Ey- ',ZF?_xZWO[ ^Ey-;'.WQ@s N}DſPӾ{j?i=o5z5}٧}sOli ?ut}r+8S5G^4A?%xWwEpbg΍ ZWHOr;4K ]QEQEQEQEQEQEQފ;((((mQ@Q@Q@['vv =͙n]q')< 9UuOm%`C$!Id"$BY %U$w4?|k>'P1i+6$x GR(OO#7~1߭fKa^YV (#2mU1  gֹa|IկL׉5"ظ+[.3X|O?J<9mwŶdžidhi.hA$11:xUjI#';Nz@O:'Xm\1XVWUeO+_b[$"R>Wjg? Cr}qQ## #[,fOٺܫAZhqx$|^8$*SX{þ!QEiLFuVz y> ݌ w#|,ĺzOjV`T~ AXNO[k cocK(27$`d3Os)|QjdDG.UB1qgn©=\kw6!jF6  y9>@3㯈kuO26]bRg'ۮ񏄵]W߇uhKYYW]Ez<xCҢXH݆x rpH*<f;OQzI-Ӡ,2Z (ӭaSJaM¯a*P|γ?&W1fqΏ'|Dt-'O|Asnz^-;NUKp >xYޣ]C*+KR$% >gqMwPeu?>JtIY#3ք[Akᫌ6oQP۔(GP/V(DA T<Cfgn|+ yw)6ǐBrs3vPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPGz(@(((((QEQEQEpUhikwb) -׮x%'-l]3ګjA %POBwc|vۼNpsT$is'O [#n6׶ؙz(%NOր;w߄5gOL*h=p8X_u+,u*L ' O¼S_/SKDM:kE5HTC RPSIOŅop\DA 999h RaBR M<ȑDXm8@u#Z2+U}%ٜ;Ip#^1hگڮ/b[213$NeW$t[>2͠XZiys5ȴcYc&%z KZҴdG5;;u1Fjk=N..໶| 88`pyWxPҼA3zMCZ{YŽ0ؽPF c# –Wi[D+.ʱu=Q8;+$FHf[lR BeE NGOZ_ uo j_{hA$QTbʤ`1,Aol s /'mP5?OD Jd<{E,s’"dt9 B+2OzKii{GvI]yWxFt~5X}.W.Z -8=''|;ԼC2[.6,SvB z_O1%/f䨷QCp%,Fs\=NmZޣoyRF4,U@pI5|1/ZM梏5BG%y@OX.GiK^qG d2W!@'5v7oKGRV9'*' 7iLM =-+XUH[Ny]ƵkR }: -߶80Xtpn`:z֛Ț^a|р]mnRRqW.n쭤( wҶ^pG=x{y 񘽯&ޒ%C)ڌ#o^HۭƥZY@.fXԶ ۖ g{S_Yң҆&fqDDw:׊|$𾙮wzk|V|;q~R5ow(D7vu隁H-&]1*IʎG Z;y T8O^]9InAnI\7WDŽ,I{{ $9~%ԴxWCkakIvj C ?Cһ3/[?[LgZR~sڴQڏ} o[Tv3G!!'9h։dAWxRC]`\M+oD c>@;gL!u;GH H< N{M{]!eHSQ]ܥR) m#@8/K;ڝ-1'GԀ}}t,14s5=/5I6TJЄr/ߡWÚv3ꗚhI1BJ.e$>g3iڃ^Jy2Ѵ ㍣j|O oX}<[]j$r}3_<<>մ{mW[\q瓅@?u߆Q:طo+RXόlF@(( ?$ڄ+6U8>L紼l;[> UPo Ѹ8=rP:u~4[Aif.g~J|6J(}Mx~IW[MCgm`>mzqӚϻBcI~$:kNAR1z\OH8{v]KH{A.wY݆ @ q9$QEQEQEQEQEQEQފ;((((mQ@Q@Q@W 7$uM"=7_%-{/]Axc5LGjKOFM~{:}4P^|~UK{a$upS?FF4=fAӦ(s1Xnt$V<.]7Ú^6FfXuUw0# (kq@x![X+!lc/>a9x#ouKY{+6@Pui OY%ڞvqoZs#{2TOADu}*+{xUӴɣ 2ǒ8TP {z+W_ntwKqk qJcۮ0q<7"MOL?a~]E徣co{i*mqѕAO@7Ÿj ^==veT(09V=;֗|=yH>?s96 0]=7?o!)u}^mBD%(q*Lቭ"!d5U$)Rr~ z;npPp~p$-mnj̘#s ڷgM?:DWZ^ԑ3R~l߀0n{c:Nx j2Ϙ9#0A `Wmk :;[d([NI^kO'oL[)C+;I\ jOiwWtȬ&ʤB(x{#xZ|EN7oYvx 5hUB%^$F|ӷ] ƣSw,"Ӥ9MA;CFGFӸ g'oM'^5ԯm|MJV2p #u-VfuJW"qzˈF>o)@@{=y秠(o x?u 鶺K&IXn'N87-|9{:ou,&ؘ"s2p0G]ψ?h3lQcTN6#r<xF-][o]x'-@S~ﰭ ~F'xM#cn *+q!;223<Eyy#E{-[hq@P2<÷㨨jVu/gQf[ }c2;\>Uy( E#9 P5gN?oz@rrG ;Eއnq}U>`Fgj柣Emb!9rph9=<>6kM>T7%ӈnYYQh;t^!=֯`<5k\=@ UsW#meQ8#q^M#? F|7o ky;yWvRq^Pi-ҵ{i1H;E T sO^>hZ$'ٙ]JpJ*ÿz'OCNGeZ1$7BA9V^u ]*gS҄ 'g'd3kh*5t uܚWKv!xޥxVkF%cN JgZ^06D čm@2Q. y%bEc#QP|7}qBj1W"lćܫcq(QTkʵ=6Xh_ <}Ghȸ z{׫P|1c?4%͔xϕgPX2ryG_ ~F^$0s\0ڤ $yrv 'j$ >nki>;L>c-|3HE]sνմk/zgC̊\e=X$rqQ:x?\Dc"l8%R\8&{KRt2*A*\]xn_;u){&i7%Xa$9|IOuiɦE,j , ԍ߅Q/ĭ]ni[_ TO|g5ß3sNuykx{|"POqW'x[W;GN]CU[Vo2ʅ;Pk?I&%RÈr:}kOA|e;C y_2U#y*94>/g#_\]].xWA* vt~>#kzUz\\fJ61 ;I ᏛpNEe[zu*R}U,ڪUAcܞ=^;Jվc X?^}k'_ttte-%ĨH$ =WIEQEQECwimjז[2F< 1[ADC4Ptv@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@製:(((((z[ 0D[SOalngs0-0z[ 0 DTahomags0-0z[ 00DWingdings0-0z[ 0 A .  @n?" dd@  @@`` tl0%r     !#$%'_R$qNa9OpR$ ˃:qL킷;R$yT%X{YxYpJmyͳR$u`5.꿣m"FR$ou EzJՏhQ 0AA@8  3ʚ;ʚ;g4[d[d z[ 0ppp@ <4ddddL 0- 80___PPT10 pp%Antiarrhythmic drugs  OVERVIEW the heart contains specialized cells that exhibit automaticity, that is, they can intrinsically generate rhythmic action potentials in the absence of external stimuli. 2 k INTRODUCTION TO THE ARRHYTHMIAS cardiac arrhythmias may cause the heart (1) to beat too slowly (sinus bradycardia); (2) to beat too rapidly (sinus or ventricular tachycardia, atrial or ventricular premature depolarization, atrial flutter); (3) to respond to impulses originating from sites other than the SA node; (4) to respond to impulses traveling along accessory (extra) pathways that lead to deviant depolarizations (A-V reentry). PPG ?*Causes of arrhythmias Abnormal automaticity: The SA node shows the fastest rate of Phase 4 depolarization if cardiac sites other than the SA node show enhanced automaticity, they may generate competing stimuli, , v (Effect of drugs on automaticity Most of the antiarrhythmic agents suppress automaticity (1) by decreasing the slope of Phase 4 (diastolic) depolarization (2) by raising the threshold of discharge to a less negative voltage. ,  #Abnormalities in impulse conduction/Impulses from higher pacemaker centers are normally conducted down pathways that bifurcate to activate the entire ventricular surface .A phenomenon called reentry can occur if a unidirectional block caused by myocardial injury or a prolonged refractory period results in an abnormal conduction pathway. 0Z0 ,Effects of drugs on conduction abnormalitiesAntiarrhythmic agents prevent reentry by slowing conduction and/or increasing the refractory period required to convert a unidirectional block into a bidirectional block.  Antiarrhythmic drugs Gthe antiarrhythmic drugs can modify impulse generation and conduction. .    5    CLASS I ANTIARRHYTHMIC DRUGS $Class I antiarrhythmic drugs act by blocking voltage-sensitive sodium channels Class I antiarrhythmic drugs therefore generally cause a decrease in excitability and conduction velocity. ,AV Use-dependence :Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing. This property is called use-dependence;Z;g   Quinidine  Quinidine is the prototype Class IA drug. At high doses, it can actually precipitate arrhythmias, which can lead to fatal ventricular fibrillation.    Mechanism of actionQuinidine binds to open and inactivated sodium channels and prevents sodium influx, thus slowing the rapid upstroke during Phase 0 . It also decreases the slope of Phase 4 spontaneous depolarization.   ActionsQuinidine inhibits ectopic arrhythmias and ventricular arrhythmias caused by increased normal automaticity. Quinidine also prevents reentry arrhythmias H  D  %Therapeutic usesin the treatment of a wide variety of arrhythmias, including atrial, AV junctional, and ventricular tachyarrhythmias. Quinidine is used to maintain sinus rhythm after direct current cardioversion of atrial flutter or fibrillation and to prevent frequent ventricular tachycardia. t=  7 KAdverse effectsA potential adverse effect of quinidine is exacerbation of the arrhythmia. Quinidine may cause SA and AV block or asystole. At toxic levels, the drug may induce ventricular tachycardia. Cardiotoxic effects are exacerbated by hyperkalemia. b $ A   Procainamide  p1. Actions: This Class IA drug, a derivative of the local anesthetic procaine shows actions similar to those of PharmacokineticscProcainamide is absorbed following oral administration. Procainamide has a relatively short half-life of 2-3 hours. A portion of the drug is acetylated in the liver to N- acetylprocainamide (NAPA), which has little effect on the maximum polarization of Purkinje fibers but prolongs the duration of the action potential. NAPA is eliminated via the kidneydd6 - gAdverse effectsWprocainamide causes a high incidence of side effects, including a reversible lupus erythematosus-like syndrome that develops in 25 to 30% of patients. Toxic concentrations of procainamide may cause asystole or induction of ventricular arrhythmias. Central nervious system (CNS) side effects include depression, hallucination and psychosis. XZXZ G P  3N Lidocaine  Lidocaine is a Class IB drug. The IB agents rapidly associate and dissociate from sodium channels. Class IB drugs are particularly useful in treating ventricular arrhythmias. Lidocaine is the drug of choice for emergency treatment of cardiac arrhythmias. Z$  HActionsLidocaine, shortens phase 3 repolarization and decreases the duration of the action potential lidocaine suppresses arrhythmias caused by abnormal automaticity. abolishes ventricular reentry. H 5 + "Pharmacokinetics\Lidocaine is given intravenously because of extensive first-pass transformation by the liver TAdverse effectsLidocaine has a fairly wide toxic-to-therapeutic ratio; it shows little impairment of left ventricular function, The CNS effects include drowsiness, slurred speech, confusion, and convulsions; cardiac arrhythmias may also occur. Z CLASS II ANTIARRHYTHMIC DRUGS $3The Class II agents include the beta-adrenergic antagonists. These drugs diminish Phase 4 depolarization, thus depressing automaticity, prolonging AV conduction, and decreasing heart rate and contractility. Class II agents are useful in treating tachyarrhythmias caused by increased sympathetic activity. 44H{     q    +   Propranolol reduces the incidence of sudden arrhythmic death after myocardial infarction The mortality rate in the first year after a heart attack is significantly reduced by propranolol, partly because of its ability to prevent ventricular arrhythmias.  E!CLASS III ANTIARRHYTHMIC DRUGS 5Class III agents block potassium channels and thus diminish the outward potassium current during repolarization of cardiac cells. prolong the duration of the action potential without altering Phase 0 of depolarization or the resting membrane potential. Instead, they prolong the effective refractory period. 660a7  "# P|(  D  C A1P  s *޽h ?"` 333380___PPT10.,P^| p|(  D  C A2iP  s *޽h ?"` 333380___PPT10.,{ąrn" W? Jo#-( / 00DArialngs0-0z[ 0D[SOalngs0-0z[ 0 DTahomags0-0z[ 00DWingdings0-0z[ 0 A .  @n?" dd@  @@`` |t8&u!    !#$%')_R$qNa9OpR$ ˃:qL킷;R$yT%X{YxYpJmyͳR$u`5.꿣m"FR$ou EzJՏhQ 0AA@8  3ʚ;ʚ;g4[d[d z[ 0ppp@ <4ddddL 0- 80___PPT10 ppJ'Antiarrhythmic drugs  OVERVIEW the heart contains specialized cells that exhibit automaticity, that is, they can intrinsically generate rhythmic action potentials in the absence of external stimuli. 2 k INTRODUCTION TO THE ARRHYTHMIAS cardiac arrhythmias may cause the heart (1) to beat too slowly (sinus bradycardia); (2) to beat too rapidly (sinus or ventricular tachycardia, atrial or ventricular premature depolarization, atrial flutter); (3) to respond to impulses originating from sites other than the SA node; (4) to respond to impulses traveling along accessory (extra) pathways that lead to deviant depolarizations (A-V reentry). PPG ?*Causes of arrhythmias Abnormal automaticity: The SA node shows the fastest rate of Phase 4 depolarization if cardiac sites other than the SA node show enhanced automaticity, they may generate competing stimuli, , v (Effect of drugs on automaticity Most of the antiarrhythmic agents suppress automaticity (1) by decreasing the slope of Phase 4 (diastolic) depolarization (2) by raising the threshold of discharge to a less negative voltage. ,  #Abnormalities in impulse conduction/Impulses from higher pacemaker centers are normally conducted down pathways that bifurcate to activate the entire ventricular surface .A phenomenon called reentry can occur if a unidirectional block caused by myocardial injury or a prolonged refractory period results in an abnormal conduction pathway. 0Z0 ,Effects of drugs on conduction abnormalitiesAntiarrhythmic agents prevent reentry by slowing conduction and/or increasing the refractory period required to convert a unidirectional block into a bidirectional block.  Antiarrhythmic drugs Gthe antiarrhythmic drugs can modify impulse generation and conduction. .    5    CLASS I ANTIARRHYTHMIC DRUGS $Class I antiarrhythmic drugs act by blocking voltage-sensitive sodium channels Class I antiarrhythmic drugs therefore generally cause a decrease in excitability and conduction velocity. ,AV Use-dependence :Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing. This property is called use-dependence;Z;g   Quinidine  Quinidine is the prototype Class IA drug. At high doses, it can actually precipitate arrhythmias, which can lead to fatal ventricular fibrillation.    Mechanism of actionQuinidine binds to open and inactivated sodium channels and prevents sodium influx, thus slowing the rapid upstroke during Phase 0 . It also decreases the slope of Phase 4 spontaneous depolarization.   ActionsQuinidine inhibits ectopic arrhythmias and ventricular arrhythmias caused by increased normal automaticity. Quinidine also prevents reentry arrhythmias H  D  %Therapeutic usesin the treatment of a wide variety of arrhythmias, including atrial, AV junctional, and ventricular tachyarrhythmias. Quinidine is used to maintain sinus rhythm after direct current cardioversion of atrial flutter or fibrillation and to prevent frequent ventricular tachycardia. t=  7 KAdverse effectsA potential adverse effect of quinidine is exacerbation of the arrhythmia. Quinidine may cause SA and AV block or asystole. At toxic levels, the drug may induce ventricular tachycardia. Cardiotoxic effects are exacerbated by hyperkalemia. b $ A   Procainamide  p1. Actions: This Class IA drug, a derivative of the local anesthetic procaine shows actions similar to those of PharmacokineticscProcainamide is absorbed following oral administration. Procainamide has a relatively short half-life of 2-3 hours. A portion of the drug is acetylated in the liver to N- acetylprocainamide (NAPA), which has little effect on the maximum polarization of Purkinje fibers but prolongs the duration of the action potential. NAPA is eliminated via the kidneydd6 - gAdverse effectsWprocainamide causes a high incidence of side effects, including a reversible lupus erythematosus-like syndrome that develops in 25 to 30% of patients. Toxic concentrations of procainamide may cause asystole or induction of ventricular arrhythmias. Central nervious system (CNS) side effects include depression, hallucination and psychosis. XZXZ G P  3N Lidocaine  Lidocaine is a Class IB drug. The IB agents rapidly associate and dissociate from sodium channels. Class IB drugs are particularly useful in treating ventricular arrhythmias. Lidocaine is the drug of choice for emergency treatment of cardiac arrhythmias. Z$  HActionsLidocaine, shortens phase 3 repolarization and decreases the duration of the action potential lidocaine suppresses arrhythmias caused by abnormal automaticity. abolishes ventricular reentry. H 5 + "Pharmacokinetics\Lidocaine is given intravenously because of extensive first-pass transformation by the liver TAdverse effectsLidocaine has a fairly wide toxic-to-therapeutic ratio; it shows little impairment of left ventricular function, The CNS effects include drowsiness, slurred speech, confusion, and convulsions; cardiac arrhythmias may also occur. Z CLASS II ANTIARRHYTHMIC DRUGS $3The Class II agents include the beta-adrenergic antagonists. These drugs diminish Phase 4 depolarization, thus depressing automaticity, prolonging AV conduction, and decreasing heart rate and contractility. Class II agents are useful in treating tachyarrhythmias caused by increased sympathetic activity. 44H{     q    +   Propranolol reduces the incidence of sudden arrhythmic death after myocardial infarction The mortality rate in the first year after a heart attack is significantly reduced by propranolol, partly because of its ability to prevent ventricular arrhythmias.  E!CLASS III ANTIARRHYTHMIC DRUGS 5Class III agents block potassium channels and thus diminish the outward potassium current during repolarization of cardiac cells. prolong the duration of the action potential without altering Phase 0 of depolarization or the resting membrane potential. Instead, they prolong the effective refractory period. 660a7  "#$ CLASS IV ANTIARRHYTHMIC DRUGS are calcium channel blockers. They decrease the inward current carried by calcium, resulting in a decrease in the rate of Phase 4 spontaneous depolarization and slowed conduction in tissues dependent on calcium currents, such as the AV node./$  $(  r  S 4 0    r  S  0   H  0޽h ? 333380___PPT10.,04ޫr$B  ? n $6( / 00DArialngs0-0z[ 0D[SOalngs0-0z[ 0 DTahomags0-0z[ 00DWingdings0-0z[ 0 A .  @n?" dd@  @@`` `+&    !#$%')*+,-._R$qNa9OpR$ ˃:qL킷;R$yT%X{YxYpJmyͳR$u`5.꿣m"FR$ou EzJՏhQ 0AA@8  3ʚ;ʚ;g4[d[d z[ 0ppp@ <4ddddL 0- 80___PPT10 ppr0Antiarrhythmic drugs  OVERVIEW the heart contains specialized cells that exhibit automaticity, that is, they can intrinsically generate rhythmic action potentials in the absence of external stimuli. 2 k INTRODUCTION TO THE ARRHYTHMIAS cardiac arrhythmias may cause the heart (1) to beat too slowly (sinus bradycardia); (2) to beat too rapidly (sinus or ventricular tachycardia, atrial or ventricular premature depolarization, atrial flutter); (3) to respond to impulses originating from sites other than the SA node; (4) to respond to impulses traveling along accessory (extra) pathways that lead to deviant depolarizations (A-V reentry). PPG ?*Causes of arrhythmias Abnormal automaticity: The SA node shows the fastest rate of Phase 4 depolarization if cardiac sites other than the SA node show enhanced automaticity, they may generate competing stimuli, , v (Effect of drugs on automaticity Most of the antiarrhythmic agents suppress automaticity (1) by decreasing the slope of Phase 4 (diastolic) depolarization (2) by raising the threshold of discharge to a less negative voltage. ,  #Abnormalities in impulse conduction/Impulses from higher pacemaker centers are normally conducted down pathways that bifurcate to activate the entire ventricular surface .A phenomenon called reentry can occur if a unidirectional block caused by myocardial injury or a prolonged refractory period results in an abnormal conduction pathway. 0Z0 ,Effects of drugs on conduction abnormalitiesAntiarrhythmic agents prevent reentry by slowing conduction and/or increasing the refractory period required to convert a unidirectional block into a bidirectional block.  Antiarrhythmic drugs Gthe antiarrhythmic drugs can modify impulse generation and conduction. .    5    CLASS I ANTIARRHYTHMIC DRUGS $Class I antiarrhythmic drugs act by blocking voltage-sensitive sodium channels Class I antiarrhythmic drugs therefore generally cause a decrease in excitability and conduction velocity. ,AV Use-dependence :Class I drugs bind more rapidly to open or inactivated sodium channels than to channels that are fully repolarized following recovery from the previous depolarization cycle. Therefore, these drugs show a greater degree of blockade in tissues that are frequently depolarizing. This property is called use-dependence;Z;g   Quinidine  Quinidine is the prototype Class IA drug. At high doses, it can actually precipitate arrhythmias, which can lead to fatal ventricular fibrillation.    Mechanism of actionQuinidine binds to open and inactivated sodium channels and prevents sodium influx, thus slowing the rapid upstroke during Phase 0 . It also decreases the slope of Phase 4 spontaneous depolarization.   ActionsQuinidine inhibits ectopic arrhythmias and ventricular arrhythmias caused by increased normal automaticity. Quinidine also prevents reentry arrhythmias H  D  %Therapeutic usesin the treatment of a wide variety of arrhythmias, including atrial, AV junctional, and ventricular tachyarrhythmias. Quinidine is used to maintain sinus rhythm after direct current cardioversion of atrial flutter or fibrillation and to prevent frequent ventricular tachycardia. t=  7 KAdverse effectsA potential adverse effect of quinidine is exacerbation of the arrhythmia. Quinidine may cause SA and AV block or asystole. At toxic levels, the drug may induce ventricular tachycardia. Cardiotoxic effects are exacerbated by hyperkalemia. b $ A   Procainamide  p1. Actions: This Class IA drug, a derivative of the local anesthetic procaine shows actions similar to those of PharmacokineticscProcainamide is absorbed following oral administration. Procainamide has a relatively short half-life of 2-3 hours. A portion of the drug is acetylated in the liver to N- acetylprocainamide (NAPA), which has little effect on the maximum polarization of Purkinje fibers but prolongs the duration of the action potential. NAPA is eliminated via the kidneydd6 - gAdverse effectsWprocainamide causes a high incidence of side effects, including a reversible lupus erythematosus-like syndrome that develops in 25 to 30% of patients. Toxic concentrations of procainamide may cause asystole or induction of ventricular arrhythmias. Central nervious system (CNS) side effects include depression, hallucination and psychosis. XZXZ G P  3N Lidocaine  Lidocaine is a Class IB drug. The IB agents rapidly associate and dissociate from sodium channels. Class IB drugs are particularly useful in treating ventricular arrhythmias. Lidocaine is the drug of choice for emergency treatment of cardiac arrhythmias. Z$  HActionsLidocaine, shortens phase 3 repolarization and decreases the duration of the action potential lidocaine suppresses arrhythmias caused by abnormal automaticity. abolishes ventricular reentry. H 5 + "Pharmacokinetics\Lidocaine is given intravenously because of extensive first-pass transformation by the liver TAdverse effectsLidocaine has a fairly wide toxic-to-therapeutic ratio; it shows little impairment of left ventricular function, The CNS effects include drowsiness, slurred speech, confusion, and convulsions; cardiac arrhythmias may also occur. Z CLASS II ANTIARRHYTHMIC DRUGS $3The Class II agents include the beta-adrenergic antagonists. These drugs diminish Phase 4 depolarization, thus depressing automaticity, prolonging AV conduction, and decreasing heart rate and contractility. Class II agents are useful in treating tachyarrhythmias caused by increased sympathetic activity. 44H{     q    +   Propranolol reduces the incidence of sudden arrhythmic death after myocardial infarction The mortality rate in the first year after a heart attack is significantly reduced by propranolol, partly because of its ability to prevent ventricular arrhythmias.  E!CLASS III ANTIARRHYTHMIC DRUGS 5Class III agents block potassium channels and thus diminish the outward potassium current during repolarization of cardiac cells. prolong the duration of the action potential without altering Phase 0 of depolarization or the resting membrane potential. Instead, they prolong the effective refractory period. 660a7  "#$ CLASS IV ANTIARRHYTHMIC DRUGS are calcium channel blockers. They decrease the inward current carried by calcium, resulting in a decrease in the rate of Phase 4 spontaneous depolarization and slowed conduction in tissues dependent on calcium currents, such as the AV node%!Verapamil and diltiazem .  Verapamil shows greater action on the heart than on vascular smooth muscle, whereas nifedipine, a calcium channel-blocker used to treat hypertension exerts a stronger effect on vascular smooth muscle than on the heart. Diltiazem is intermediate in its actions. @ K } !&"Actionsverapamil and diltiazem, are more effective against the voltage-sensitive channels, causing a decrease in the slow inward current that triggers cardiac contraction Verapamfl and diltiazem bind only to open, depolarized channels, thus preventing repolarization until the drug dissociates from the channel. These drugs are therefore use-dependent that is, they block most effectively when the heart is beating rapidly, Pd    :'#Therapeutic uses%Verapamil and diltiazem are more effective against atrial than ventricular dysrhythmias. They are useful in treat- ing reentrant supraventricular tachycardia and reducing ventricular rate in atrial flutter and fibrillation. In addition, these drugs are used to treat hypertension and angina     .`($Pharmacokinetics@Verapamil and diltiazem are absorbed after oral administration. .  ))%Adverse effectsVerapamil and diltiazem have negative inotropic properties and therefore may be contraindicated in patients with preexisting depressed cardiac function. Both drugs can also cause a decrease in blood pressure caused by peripheral vasodilation. d     $  $(  r  S pA 0    r  S D 0   H  0޽h ? 333380___PPT10.-c5$  $(  r  S 9 0    r  S R 0   H  0޽h ? 333380___PPT10.-tH$  $(  r  S pTP 0   P r  S WP 0  P H  0޽h ? 333380___PPT10.-pz{$  $(  r  S &P 0   P r  S P 0  P H  0޽h ? 333380___PPT10.-7N$  $(  r  S ܧP 0   P r  S P 0  P H  0޽h ? 333380___PPT10.-r  %PCEGJ=L%?  iN)Root EntrydO)QpDPictures6Current User8SummaryInformation(C      !"#$%&'()*+,./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ IC DRUGS õƬ 29 õƬ 30CLASS IV ANTIARRHYTHMIC DRUGS Verapamil and diltiazem ActionsTherapeuti _N΢û_o(u7bc usesPharmacokineticsAdverse effects  õʾĸģ õƬ$